Abstract: A force-feedback brake pedal system for cooperative braking of an electric or hybrid vehicle having jointly a regenerative braking system and a frictional braking system includes a brake pedal which is pivotally mounted around a shaft or a bearing, an electronic circuitry which is in electrical communication with the regenerative braking system and the frictional braking system of the vehicle, an actuator for providing force feedback in accordance with the regenerative breaking and friction breaking of the vehicle, the actuator is in mechanical communication with the brake pedal. The force-feedback brake pedal system further includes a compliant element arranged between the brake pedal and the actuator, and a position sensor which, during operation, measuring the deflections of the compliant element and transmitting data to the electronic circuitry.

Abstract: A heat exchanger having a heat transfer surface provided with hyperthermophilic bacteria. The hyperthermophilic bacteria can be from the genera Archaea. The hyperthermophilic bacteria can further be from the genus Sulfolobus, and the hyperthermophilic bacteria can further be from the species Sulfolobus solfataricus. The heat exchanger can be adapted to pool-boiling heat transfer.

Abstract: An overspeed emergency brake system includes an overspeed detector magnet generating a brake actuation force and a kinematic constraint element guiding the movement of the magnet. The magnet and a kinematic constraint element in the brake system are arranged such that a linear brake actuation force is generated at a normal operating speed condition (i.e in a first position of the magnet with respect to the kinematic constraint element), due to the movement of the kinematic constraint element when guiding the magnet along a reaction surface and the kinematic constraint element converts the linear speed-force relationship into a nonlinear speed-force relationship in an overspeed condition (i.e a second position), while the magnet translates with respect to the kinematic constraint element generating a sharply increasing force for triggering the overspeed emergency brake.

Abstract: A method for generating a tool path to manufacture a part using a computer numerical control system includes the steps of; generating an initial design part geometry from a geometry modelling program as an input, creating a pre-finished in-process workpiece geometry before a finishing process, controlling a stock thickness distribution of the pre-finished in-process workpiece geometry by following the tool path, wherein the stock thickness distribution is based on at least one ruling function on a basis of at least one predetermined direction, wherein the at least one ruling function is used to determine a stock thickness at a tool location to obtain a variable stock thickness distribution around a design part; locating at least one tool to be defined with respect to the initial design part geometry.

Abstract: The present system relates to a mains-powerable, compact and customizable alternating current magnetic field plate for magnet-assisted transfection of genes to target cells. Magnet plate is based on at least one alternating current electromagnet comprising a laminated steel stack core and a multi-layer, multi-turn coil wound longitudinally therearound. The system includes a voltage rating adjustment controller, as well as a current adjuster for selective control of magnetic force applied to genetic material for delivery. Rapid magnetic field polarity switching exacts lateral motion efficiently and uniformly, thus improving the distribution of means, such as SPIONS, used to transfect cells with genes of interest, and in turn enhancing gene delivery and tissue localization, especially for hard-to-transfect genes, compared to DC magnet plates.

Abstract: Pol ? protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol ?. The compounds were shown to directly interact with Pol ? and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.

Abstract: A production method of boron carbide nano-sized particles and/or submicron particles includes the following sequential steps: obtention of a fluid mixture including elemental boron, glycerin and one or more carboxylic add, wherein a molar ratio of glycerin to the one or more carboxylic acids is within a range between 10:1 and 10:7.5. Heating of the fluid mixture to obtain a first mid-product in a form of a gel including borate ester bonds. Solidification of the first mid-product by heating a reaction product to obtain a second mid-product in solid form. Sintering the second mid-product to obtain boron carbide in a form of particles.

Abstract: A full-duplex radio system includes a monostatic antenna, digital self-interference cancellation (DSIC) and cyclic prefix noise reduction (CPNR) method and circuitry applying said method suitable for orthogonal frequency division multiplexing (OFDM) based full-duplex wireless communications. Said system, method and circuitry applying said method are implementable within the paradigm of in-band full-duplex (IBFD) monostatic antenna architecture, an embodiment of which comprises a dual-polarized, slot-coupled antenna.

Abstract: A method for automatic printing of a three dimensional heterogeneous structure in accordance with a computer-aided design procedure, including the steps of: aspirating a first portion consisting of a first material (M1) in liquid form, from a first liquid container into a capillary (C); aspirating a second portion consisting of a second material (M2) in liquid form different than the first material (M1), from a second liquid container into said capillary (C), such that the first portion and the second portion constitute longitudinally different parts of a longitudinally heterogeneous filament (F) encompassed by the capillary (C); and extraction of the filament (F) from the capillary (C) thus laying it as a portion of a printed layer.

Abstract: An overspeed emergency brake system includes an overspeed detector magnet generating a brake actuation force and a kinematic constraint element guiding the movement of the magnet. The magnet and a kinematic constraint element in the brake system are arranged such that a linear brake actuation force is generated at a normal operating speed condition (i.e in a first position of the magnet with respect to the kinematic constraint element), due to the movement of the kinematic constraint element when guiding the magnet along a reaction surface and the kinematic constraint element converts the linear speed-force relationship into a nonlinear speed-force relationship in an overspeed condition (i.e a second position), while the magnet translates with respect to the kinematic constraint element generating a sharply increasing force for triggering the overspeed emergency brake.

Abstract: A full-duplex radio system includes a monostatic antenna, digital self-interference cancellation (DSIC) and cyclic prefix noise reduction (CPNR) method and circuitry applying said method suitable for orthogonal frequency division multiplexing (OFDM) based full-duplex wireless communications. Said system, method and circuitry applying said method are implementable within the paradigm of in-band full-duplex (IBFD) monostatic antenna architecture, an embodiment of which comprises a dual-polarized, slot-coupled antenna.

Abstract: An online learning-based smart steering system and method comprises an online kernel perceptron classifier. The smart steering approach/method performs learning sequentially at the cloud from the entire data of multiple mesh networks, and, operates at APs for steering; both of which are executed in real-time. The system and method uses network features such as current RSSI (received signal strength indicator), current cost, target RSSI and target cost for every steering action resulting in either success of failure. The system and method uses a classifier based on this data for obtaining a model in the feature space which predicts whether a steering action can succeed or not before it is issued.

Abstract: A force-feedback brake pedal system for cooperative braking of an electric or hybrid vehicle having jointly a regenerative braking system and a frictional braking system includes a brake pedal which is pivotally mounted around a shaft or a bearing, an electronic circuitry which is in electrical communication with the regenerative braking system and the frictional braking system of the vehicle, an actuator for providing force feedback in accordance with the regenerative breaking and friction breaking of the vehicle, the actuator is in mechanical communication with the brake pedal. The force-feedback brake pedal system further includes a compliant element arranged between the brake pedal and the actuator, and a position sensor which, during operation, measuring the deflections of the compliant element and transmitting data to the electronic circuitry.

Abstract: A heat exchanger having a heat transfer surface provided with hyperthermophilic bacteria. The hyperthermophilic bacteria can be from the genera Archaea. The hyperthermophilic bacteria can further be from the genus Sulfolobus, and the hyperthermophilic bacteria can further be from the species Sulfolobus solfataricus. The heat exchanger can be adapted to pool-boiling heat transfer.

Abstract: An admixture including at least one copolymer having a backbone. The backbone including at least one electrically charged monomer. The at least one copolymer is a grafted copolymer having mean molecular weight within a range between 600 g/mol and 3000 g/mol on side chains of the grafted copolymer. An additive manufacturing ink, Filament of the additive manufacturing ink, and inkjet printing ink including the admixture.

Abstract: An online learning-based smart steering system and method comprises an online kernel perceptron classifier. The smart steering approach/method performs learning sequentially at the cloud from the entire data of multiple mesh networks, and, operates at APs for steering; both of which are executed in real-time. The system and method uses network features such as current RSSI (received signal strength indicator), current cost, target RSSI and target cost for every steering action resulting in either success of failure. The system and method uses a classifier based on this data for obtaining a model in the feature space which predicts whether a steering action can succeed or not before it is issued.

Abstract: The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.

Abstract: The present system relates to a mains-powerable, compact and customizable alternating current magnetic field plate for magnet-assisted transfection of genes to target cells. Magnet plate is based on at least one alternating current electromagnet comprising a laminated steel stack core and a multi-layer, multi-turn coil wound longitudinally therearound. The system includes a voltage rating adjustment controller, as well as a current adjuster for selective control of magnetic force applied to genetic material for delivery. Rapid magnetic field polarity switching exacts lateral motion efficiently and uniformly, thus improving the distribution of means, such as SPIONS, used to transfect cells with genes of interest, and in turn enhancing gene delivery and tissue localization, especially for hard-to-transfect genes, compared to DC magnet plates.

Abstract: A flow system for avoiding particle agglomeration in nanofluids, including a flow restrictive element, wherein the flow restrictive element in use provides sudden expansion to the fluid such that cavitation takes place the fluid upon exiting the flow restrictive element. The flow system includes the flow restrictive element having a hydraulic diameter within a range between 0.5 ?m and 250 ?m, a vicinity of the flow restrictive element is provided with a heater, adapted to heat the nanofluid in the vicinity of the flow restrictive element.

Abstract: A full-duplex self-interference cancelling system operable in 28 GHz data rate levels, therefore well compatible with 5G systems such as massive MIMO transmitter-receiver radios and mm-waves, designed to include an antenna to improve signal-to-noise ratios (SNR) and elimination of self-interference-based noise and an adaptive, blind performing self-interference canceller module. In other words, the present invention comprises a self-interference canceller using variable-gin amplifiers to adjust a receiving signal post-dissection into in-phase and quadrant constituents thereof via an I/Q modulator, entire process of which is overseen and dictated by a digital control block.