Patents Assigned to Sagres Discovery, Inc.
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Patent number: 8252267Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of diseases, including cancer. The invention provides novel splice products of human DKKL-1 gene. The present invention provides methods of using polynucleotides having the novel splice products of the human DKKL-1 sequences, their corresponding gene products and modulators of the DKKL-1 splice products for the detection, diagnosis, prevention and/or treatment of associated cancers.Type: GrantFiled: March 30, 2006Date of Patent: August 28, 2012Assignee: Sagres Discovery, Inc.Inventors: Albert Lai, Robert Booher
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Patent number: 7919246Abstract: This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the SEM A4D gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the SEMA4D gene.Type: GrantFiled: April 7, 2006Date of Patent: April 5, 2011Assignees: Novartis Vaccines and Diagnostics, Inc., Sagres Discovery, Inc.Inventors: Albert Lai, Abdallah Fanidi, Robert Booher, Christin Tse, Xie Xu, Guoying Yu, Edward Moler, Michael Rowe
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Patent number: 7892730Abstract: The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially lymphoma carcinomas. In addition, the present invention describes the use of novel compositions for use in screening methods.Type: GrantFiled: March 1, 2002Date of Patent: February 22, 2011Assignee: Sagres Discovery, Inc.Inventors: David W. Morris, Eric K. Engelhard
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Patent number: 7820447Abstract: The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially lymphoma carcinomas. In addition, the present invention describes the use of novel compositions for use in screening methods.Type: GrantFiled: December 26, 2001Date of Patent: October 26, 2010Assignee: Sagres Discovery Inc.Inventors: David W. Morris, Eric K. Engelhard
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Patent number: 7816076Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.Type: GrantFiled: October 24, 2005Date of Patent: October 19, 2010Assignee: Sagres Discovery, Inc.Inventors: David W. Morris, Marc S. Malandro
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Publication number: 20100216713Abstract: The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially breast cancers. In addition, the present invention describes the use of novel compositions for use in screening methods. The invention provides compositions and methods associated with altered expression of PRLR in cancer.Type: ApplicationFiled: January 12, 2010Publication date: August 26, 2010Applicant: Sagres Discovery Inc.Inventors: David W. Morris, Eric K. Engelhard
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Patent number: 7767387Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.Type: GrantFiled: June 13, 2003Date of Patent: August 3, 2010Assignee: Sagres Discovery, Inc.Inventors: David W. Morris, Marc S. Malandro
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Patent number: 7700274Abstract: The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially breast cancers. In addition, the present invention describes the use of novel compositions for use in screening methods.Type: GrantFiled: March 20, 2002Date of Patent: April 20, 2010Assignee: Sagres Discovery, Inc.Inventors: David W. Morris, Eric K. Engelhard
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Patent number: 7645441Abstract: The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially breast cancers. In addition, the present invention describes the use of novel compositions for use in screening methods. The invention provides compositions and methods associated with altered expression of PRLR in cancer.Type: GrantFiled: March 20, 2002Date of Patent: January 12, 2010Assignee: Sagres Discovery Inc.Inventors: David W. Morris, Eric K. Engelhard
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Publication number: 20090317391Abstract: This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the tm-PTP? gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the tm-PTP? gene.Type: ApplicationFiled: April 7, 2006Publication date: December 24, 2009Applicants: NOVARTIS VACCINES AND DIAGNOSTICS INC., SAGRES DISCOVERY INC.Inventors: Abdullah Fanidi, Robert Booher, Albert Lai, Christin Tse
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Publication number: 20090215711Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.Type: ApplicationFiled: April 30, 2004Publication date: August 27, 2009Applicant: Sagres Discovery, Inc.Inventors: David W. Morris, Marc S. Malandro, Albert Lai, Christin Tse, Ali Fattaey
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Patent number: 7332281Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.Type: GrantFiled: April 27, 2004Date of Patent: February 19, 2008Assignee: Sagres Discovery, Inc.Inventors: David W. Morris, Marc S. Malandro, Albert Lai, Christin Tse, Ali Fattaey
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Publication number: 20040197778Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is dys-regulated in cancer tissues. The present invention provides CA polypeptides associated with cancer and provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.Type: ApplicationFiled: December 26, 2002Publication date: October 7, 2004Applicant: Sagres Discovery, inc.Inventors: David W. Morris, Marc S. Malandro