Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: The invention relates to a disposable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver.

Abstract: A sensor device to be attached to a drug delivery device includes an array of conducting elements each forming part of a respective resonant circuit and each operable to have a signal applied to it. The drug delivery device has a first movable element supporting a conductive region, which is configured to move along a path parallel to a longitudinal axis of the drug delivery device. When the sensor device is attached to the drug delivery device, the conducting elements are arranged such that each resonant circuit is operable to output a signal indicative of the proximity of the conductive region supported on the first moveable element to the respective conducting element of each resonant circuit. The sensor device includes circuitry to receive the signals output from the resonant circuit and, based on the received signals, determines information associated with a location along the path of the first movable element.

Abstract: The present invention relates to metformin for use in treating a patient, wherein the patient exhibits an increased level of GDF15 in response to metformin treatment; to methods of identifying a patient who will benefit or who will not benefit from metformin treatment; methods of treating a patient at risk of developing or suffering from a disease or disorder comprising administering therapeutically effective amount of metformin; methods of adapting the dosage of metformin; the usage of GDF15 as biomarker for identifying a patient who will benefit or who will not benefit from metformin treatment, kits for use in identifying a patient who will benefit from metformin treatment and the use of the kits, as well as methods of treating a patient or who will not benefit from metformin treatment.

Abstract: A drug delivery device for delivering a medicament includes a housing arranged to contain a container, a receiver coil, and an energy storage unit. The receiver coil is arranged to receive energy from a transmitter coil by electromagnetic induction. The energy storage unit is arranged to be charged by at least a portion of the energy received by the receiver coil. At least a portion of the energy received by the receiver coil is converted to heat energy. The receiver coil is arranged in the drug delivery device to transfer the heat energy to the container to heat medicament contained in the container. A system comprising the drug delivery device is also disclosed.

Abstract: A cartridge carrier assembly for a medicament delivery device comprises a cartridge carrier adapted to receive a cartridge defining a cavity containing a dose of a medicament, a needle hub being part of the cartridge carrier or coupled to the cartridge carrier such that the needle hub is fixed relative to the cartridge carrier, the needle hub adapted to receive a distal end or part of the cartridge, an injection needle having a tipped proximal needle section adapted to pierce a sealing element distally arranged on the cartridge, and a removable needle cap attachable to a distal end of the cartridge carrier. The needle hub comprises a cartridge retention feature adapted to abut the cartridge or a part thereof to limit axial movement of the cartridge in the distal direction such that the proximal needle section is spaced from the sealing element.

Abstract: An injector device includes a housing having a slot with a locking portion and a needle unit that has a needle and a slot engagement portion that extends through the slot in the housing to an external side of the housing. The needle unit is movably mounted in the housing such that movement of the needle unit relative to the housing is restricted by the slot. The injector device also includes a cartridge that is mounted in the housing, the cartridge having a reservoir for medicament. Prior to use of the injector device, the reservoir is sealed from the needle. The slot in the housing is arranged such that the needle unit can be rotated to move the slot engagement portion out of the locking portion such that the needle unit can be moved into engagement with the cartridge to place the needle in fluid communication with the reservoir.

Abstract: In one aspect the present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge or syringe filled with a liquid substance. In further aspects the disclosure relates to a cartridge equipped with such a sensor as well as to a drug delivery device equipped with such a cartridge, wherein the sensor comprises: a planar flexible foil arrangeable to an outer circumference of a barrel of the cartridge or syringe, at least a first and a second measuring electrode arranged on said foil, and at least a first and a second contact electrode arranged on said foil, wherein the first contact electrode is connected to the first measuring electrode and wherein the second contact electrode is connected to the second measuring electrode.

Abstract: The present application concerns a process for quantifying polysorbates in a sample by implementing a LC-MS analysis with an internal standard, and the process for monitoring degradation of polysorbates in such sample.

Abstract: The present disclosure relates to a needle arrangement for a drug delivery device. The needle arrangement includes a distal needle tip and a proximal needle tip. The distal needle tip is held in a distal needle holder and wherein the proximal needle tip is held in a proximal needle holder. The distal needle tip and the proximal needle tip are in fluid communication with each other through a fluid channel. The fluid channel is adapted to allow axial movement of the distal needle tip and relative to the proximal needle tip between a compact state and an extended state. A length of the needle arrangement over the distal needle tip and the proximal needle tip in the extended state is greater than in the compact state.

Abstract: A container for an injectable medicament can include an elongated body having a tubular-shaped sidewall extending along a longitudinal axis and having a distal end and a proximal end. The container can include an outlet at the distal end. The container can include a bung arranged inside the elongated body, sealingly engaged with the sidewall and slidable along the longitudinal axis relative to the sidewall. The container can include an interior volume to receive the injectable medicament and being confined by the sidewall, the outlet, and the bung. The container can include a measuring arrangement arranged in or on the bung. The measuring arrangement can include a signal generator configured to emit an electromagnetic measurement signal into or through the interior volume and a signal receiver configured to detect a feedback signal being indicative of an interaction of the measurement signal with at least one of the sidewall, the outlet or the interior volume.

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: The invention relates to a pharmaceutical composition comprising the active ingredients rosuvastatin of formula I, with the systematic name (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid or its pharmaceutically acceptable salts, esters, hydrates or solvates, and ezetimibe of formula II, with the systematic name (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one or its pharmaceutically acceptable salts, esters, hydrates or solvates, as well as a preparation method of this pharmaceutical composition. The weight ratio of the layers is 1:2 to 2:1.

Abstract: A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: A drug delivery device including: a body and a movable component arranged inside the body, a dosage selection and injection mechanism setting the position of the movable component inside the body depending on a selected dosage, a non-contact sensor configured to output signals indicative of the position of the movable component inside the body, and a processor. The processor is configured to receive the signals output from the non-contact sensor and to determine based on the signals whether the movable component is either in an initial position inside the body corresponding to no selected dosage or in a selected dosage position. Upon determining that the movable component has changed its position back from the selected dosage position to the initial position, the processor is configured to cause an indication to be output which informs a user regarding a dwell time of the drug delivery device.

Abstract: Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.

Abstract: The present invention provides methods for preventing or treating allergy. Also provided are methods for reducing the susceptibility to an allergen in a subject in need thereof. In certain embodiments, the subject has a disease or disorder selected from the group consisting of atopic dermatitis, asthma, allergic rhinitis, and eosinophilic esophagitis. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody.

Abstract: A drug injection device comprising: a cartridge configured to hold a volume of a drug; one or more processors configured to operate in at least an enabled state and a sleep state, wherein the one or more processors are configured to control an operation of the drug injection device while the one or more processors are in the enabled state; a member disposed in the cartridge, the member including at least two conductive surfaces electrically connected to the one or more processors; and a drive mechanism including a conductive element spaced from the at least two conductive surfaces, wherein the one or more processors are configured to enter the enabled state from the sleep state when the conductive element makes electrical contact with the at least two conductive surfaces.