Abstract: A process is provided for the preparation of pure cyclosporin which is purified chromatographically from a mixture of different cyclosporin forms and other substances prepared by fermentation. The process comprises feeding a mixture containing a desired form of cyclosporin with an eluent consisting of high pressure carbon dioxide and an adjuvant, into a chromatography column being packed with particles prepared of silica, and recovering from the eluent flow coming out of the chromatography column a fraction which contains the desired cyclosporin form in adequately pure form.

Abstract: The present invention is directed to an ophthalmic composition in the form of a topical aqueous solution consisting essentially ofan ophthalmologically active agent containing basic groups,an ion sensitive, hydrophilic polymer containing acidic groups in an amount of 0.004 to 1.5% by weight,at least one salt selected from the group of inorganic salts and buffers in a total amount of from 0.01 to 2.0% by weight,and optionally a wetting agent and a preservative, the ratio between salt and polymer being such that the solution exhibits a viscosity of less than 1000 mpas, and the pH of the solution is 4.0 to 8.0. The composition contains a sufficient amount of polymer to provide for a controlled absorption of the drug into the eye, its viscosity having been reduced to provide for better handling characteristics.

Abstract: The present invention relates to an eye drop formulation, which, in combination, comprises a single polymer, pilocarpine, a beta-blocking agent and an ophthalmologically acceptable carrier wherein the pH of the formulation is from 3.5 to 5.8 and the viscosity is from 10 to 25000 mPas.

Abstract: The present invention is directed to an ophthalmic composition in the form of a topical aqueous solution consisting essentially ofan ophthalmologically active agent,an ion sensitive, hydrophilic polymer in an amount a of 0.004 to 1.5% by weight,at least one salt selected from the group of inor ganic salts and buffers in a total amount of from 0.01 to 2.0% by weight,a wetting agent in an amount of 0 to 3.0% by weight,a preservative in an amount of 0 to 0.02% by weight,water, and optionallya pH regulating agent in an amount sufficient to give a pH of 4.0 to 8.0 to the composition,the ratio between salt and polymer components being such that the solution exhibits a viscosity of less than 1000 mPas. The composition contains a sufficient amount of polymer to provide for a controlled absorption of the drug into the eye, its viscosity having been reduced to provide for better handling characteristics.