Patents Assigned to SARTORIUS STEDIM NORTH AMERICA
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Publication number: 20240051206Abstract: A method of molding an article includes positioning a dissolvable insert within a mold, filling the mold with material to form an article within the mold and about the dissolvable insert, and at least partially dissolving the dissolvable insert from within the article. The dissolvable insert forms internal features of the article and includes a porous core.Type: ApplicationFiled: December 14, 2021Publication date: February 15, 2024Applicant: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick
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Publication number: 20240001980Abstract: A tilting mechanism including a base, a tilting deck, four hinges, and a lifting member. Each hinge is positioned adjacent a corner of the base and the tilting deck. Each hinge includes a globe and a receiver with the globe or the receiver secured to the base frame or the deck frame and the other secured to the other of the base or the tilting deck. Each hinge includes a locking member that selectively secures a globe within a respective receiver. The lifting member is secured at a center of the base frame and a center of the deck frame. The lifting member is configured to urge the tilting deck away from the base such that selective engagement allows for tilting of the tilting deck relative to the base in at least four directions.Type: ApplicationFiled: July 1, 2022Publication date: January 4, 2024Applicant: Sartorius Stedim North America Inc.Inventors: Peter Smit, Joseph Deacutis, Alexander Halt
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Publication number: 20230375488Abstract: An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.Type: ApplicationFiled: May 16, 2023Publication date: November 23, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Jonathan Cutting, Thomas Mickleburgh, Nicholas Phillips, Alexander Kaiser
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Publication number: 20230358343Abstract: An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.Type: ApplicationFiled: July 18, 2023Publication date: November 9, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
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Publication number: 20230349472Abstract: A clamp for closing a flexible tube includes an anvil and a hammer. The anvil includes a passage and a slot defined therein. The passage is configured to receive a flexible tube therethrough. The hammer is slidably received within the slot of the anvil. The hammer is securable in a first position in which the passage of the anvil is substantially unoccluded and a second position in which the passage of the anvil is occluded. The hammer and the anvil are configured to prevent fluid from flowing through the flexible tube received in the passage when the hammer is in the closed position. The hammer is substantially within the anvil in the closed position.Type: ApplicationFiled: December 8, 2021Publication date: November 2, 2023Applicant: Sartorius Stedim North America, lnc.Inventors: Michael Zumbrum, William Kimmick
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Publication number: 20230310272Abstract: A biocontainer including a rigid frame and a flexible membrane. The frame includes a lattice core. The membrane may flex to adjust to a volume of biomaterial sealed within the interior of the biocontainer as a temperature of the biomaterial changes.Type: ApplicationFiled: March 28, 2023Publication date: October 5, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
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Patent number: 11746929Abstract: An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.Type: GrantFiled: October 12, 2021Date of Patent: September 5, 2023Assignee: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
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Patent number: 11707413Abstract: A flexible pouch is placed in a stack provided with two plates forming a protecting body to sandwich and constrain the flexible pouch. At opposite margin portions, the protecting body has slots cooperating with positioning members of an outer shell device belonging to the stack. Between the shell parts, the plates can move during filling of the pouch and the margin portions shrink inwardly in a protecting body plane. Some of the positioning members act as stoppers, in order to have lower clearance range for shrink strokes of the protecting body in a middle part thereof, as compared to a higher clearance range at respective longitudinal end parts of the two opposite margin portions. A higher constraining effect can be obtained in a center of the pouch, to limit maximum thickness of its content, which is of interest for managing freeze/thaw operations of biopharmaceutical materials contained in the pouch.Type: GrantFiled: November 18, 2019Date of Patent: July 25, 2023Assignee: SARTORIUS STEDIM NORTH AMERICA INCInventor: Marc Sanchez
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Patent number: 11691866Abstract: A method of aseptically distributing fluid including fluidly connecting a primary vessel to a fluid distribution system via a feedline of the supply vessel to form a closed system, priming the feedline to purge trapped gases and fluid from the feedline via a purge valve, simultaneously distributing fluid from the primary vessel to a plurality of secondary vessels, sensing a complete fill of the plurality of secondary vessels with the control system, and stopping the distribution of fluid when the complete fill is sensed by the control system.Type: GrantFiled: June 29, 2021Date of Patent: July 4, 2023Assignee: Sartorius Stedim North America Inc.Inventors: Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
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Publication number: 20230202827Abstract: A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.Type: ApplicationFiled: February 8, 2023Publication date: June 29, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
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Publication number: 20230115311Abstract: An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.Type: ApplicationFiled: October 12, 2021Publication date: April 13, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Michael Zumbrum, William Kimmick, Kevin Perdue
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Patent number: 11590056Abstract: A freeze/thaw containment system is provided, having a protecting body and a flexible pouch, of a first capacity, protected by two plates of the protecting body. The two plates are attached together at a peripheral margin and form a rectangular protecting body. The peripheral margin is mounted in a stationary frame and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar to sandwich and constrain the pouch. One amongst the stationary frame and the protecting body includes fastening members for attachment of a casing configured for storing the bag, in order to have the bag fastened parallel to the protecting body. Two fasteners for cooperating with the fastening members are distributed around a bag containing part of a second capacity at least ten times inferior to the first capacity. Same biopharmaceutical composition is contained in the pouch and in the bag.Type: GrantFiled: July 30, 2020Date of Patent: February 28, 2023Assignee: SARTORIUS STEDIM NORTH AMERICAInventor: Marc Sanchez
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Patent number: 11590055Abstract: A protecting device is provided, having two plates forming a rectangular protecting body for sandwiching, constraining and protecting a flexible pouch. The two plates are attached together at a peripheral margin. Each plate has an outer surface with ribs provided in a peripheral annular region of a covering part receiving the pouch, along the peripheral margin. The peripheral margin is mounted in supporting parts of a frame and sliding positioning members may be secured to the peripheral margin, so that the peripheral margin is guided and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar, at least at panel parts surrounded by the ribs. This allows for progressive conformational change of the protecting body when filling the pouch with biopharmaceutical product, while facilitating reverse displacement of the peripheral margin during draining operations.Type: GrantFiled: July 30, 2020Date of Patent: February 28, 2023Assignee: SARTORIUS STEDIM NORTH AMERICAInventor: Marc Sanchez
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Patent number: 11577953Abstract: A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.Type: GrantFiled: November 13, 2019Date of Patent: February 14, 2023Assignee: Sartorius Stedim North America, Inc.Inventors: Michael A. Zumbrum, Kevin M. Perdue, William Kimmick, Jan Neuhaus
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Patent number: 11571359Abstract: A freeze/thaw containment system is provided, having a protecting body and a flexible pouch protected by two plates of the protecting body. The two plates are attached together at a peripheral margin and form a rectangular protecting body. The peripheral margin is mounted in supporting parts of a stationary frame and sliding positioning members are secured to the peripheral margin, so that the peripheral margin is guided and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar to sandwich and constrain the pouch in empty state of the pouch. This way of holding and retaining the protecting body allows for progressive conformational change of the protecting body due to the change in volume of the pouch when filled with a biopharmaceutical product, while facilitating reverse displacement of the peripheral margin during draining operations.Type: GrantFiled: July 30, 2020Date of Patent: February 7, 2023Assignee: SARTORIUS STEDIM NORTH AMERICAInventor: Marc Sanchez
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Publication number: 20230032121Abstract: A thermal capacitor includes a shell and a PCM. The shell includes a first major surface that is configured to contact a container including media to be frozen. The shell defines a cavity in which the PCM is disposed. The PCM has a transition temperature in a range of ?80 degrees Celsius to ?50 degrees Celsius and is configured to rapidly freeze media from room temperature to ?60 degrees Celsius with the container including the media in contact with the shell in an enclosed space.Type: ApplicationFiled: July 28, 2021Publication date: February 2, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Jonathan Cutting, Alexander Kaiser
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Publication number: 20230030092Abstract: A carrier for receiving a vessel includes a body that defines a well. The well is sized and dimensioned to receive a vessel including media. The body is configured to urge the vessel received in the well towards an external wall of the body to enhance thermal energy transfer into or out of the media within the vessel. A box assembly for supporting media during thermal changes includes a box, a vessel, and a carrier is also disclosed.Type: ApplicationFiled: July 28, 2021Publication date: February 2, 2023Applicant: Sartorius Stedim North America Inc.Inventors: Jonathan Cutting, Michael Zumbrum, Kevin Perdue
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Patent number: 11524293Abstract: Cell separation systems, and methods for separating cells from microcarriers, and harvesting the separated cells, are provided, wherein the system comprises a cell separation device, a cell settling device, and a cell screening device.Type: GrantFiled: January 17, 2018Date of Patent: December 13, 2022Assignee: Sartorius Stedim North America Inc.Inventors: Grishma Patel, Mark S. Szczypka, David Splan
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Patent number: 11506310Abstract: A fluid transfer assembly is described that includes a fitting comprising a lumen having an opening, and at least one barb, the at least one barb extending circumferentially around the lumen proximate to the opening. The assembly also includes a flexible conduit, a deformable sleeve, and an elastomeric liner disposed between the sleeve and the conduit. The fitting extends at least partially into the conduit such that the conduit extends over the at least one barb. The elastomeric liner applies substantially 360 degree radial pressure to the conduit such that the conduit is sealingly compressed around the at least one barb of the fitting. The assembly is fluid tight up to a burst pressure of the conduit.Type: GrantFiled: January 24, 2018Date of Patent: November 22, 2022Assignee: Sartorius Stedim North America Inc.Inventors: Michael A. Zumbrum, Kevin Perdue, Marc Sanchez, Jan Neuhaus
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Publication number: 20220266360Abstract: Method for the forming of a fluid-tight separating closure of a conduit (1) involving the following steps: providing of a conduit (1) with a sleeve (2), positioning of the conduit (1) with the sleeve (2) between a die (3) and a stamp (4), compressing of the sleeve (2) by a relative movement between the die (3) and the stamp (4) in order to form a closure (5); severing of the closure (5) in a compressed region (6) by a severing tool (7) such that a contact line (8) between the severing tool (7) and the sleeve (2) during severing is shorter than an obtained severing edge (9) of the sleeve (2).Type: ApplicationFiled: July 16, 2020Publication date: August 25, 2022Applicant: Sartorius Stedim North America Inc.Inventors: Dietmar Weger, Lars Bottcher, Jan Neuhaus, Michael Zumbrum