Abstract: The present invention relates to a sulfated cellulose hydrate membrane, a method for the preparation thereof and the use of the membrane as adsorption membrane for the purification of viruses.
Type:
Grant
Filed:
September 11, 2014
Date of Patent:
April 9, 2019
Assignee:
Sartorius Stedium Biotech GMBH
Inventors:
Louis Villain, Hans-Heinrich Hörl, Christian Brumm
Abstract: A method for conducting an integrity test on a flexible test container (1) includes arranging the test container (1) in an examination container (5) that is sealable in a fluid-tight manner, providing negative pressure in the interior of the sealed examination container (5), filling examination fluid into the test container (1) arranged in the examination container (5), detecting examination fluid present in the interior of the examination container (5), and providing negative pressure in the test container (1) arranged in the examination container (5) prior to filling the examination fluid. Prior to filling the examination fluid, the negative pressure in the test container (1) is lower than the negative pressure in the interior of the examination container (5), and the pressure difference between the negative pressure in the test container (1) and the negative pressure in the interior of the sealed examination container (5) is more than 0 mbar and a maximum of 100 mbar.
Abstract: A method for calibrating a pressure sensor includes connecting the pressure sensor to first and second fluid storage vessels; providing an initial fluid pressure at the pressure sensor and at the fluid storage vessels; and carrying out a pressure measurement of the initial fluid pressure at a time t0. The method then disconnects the second fluid storage vessel from the pressure sensor and the first fluid storage vessel; provides a first fluid pressure at the second fluid storage vessel; and carries out a pressure measurement of the first fluid pressure at a time t1. The method then connects the second fluid storage vessel with the pressure sensor and the first fluid storage vessel, so that a second fluid pressure between the initial and first fluid pressures is provided at the pressure sensor; and carries out a pressure measurement of the second fluid pressure at a time t2.