Abstract: The present invention discloses phosphate esters of florfenicol (prodrugs) and florfenicol analogs having superior water solubility that are hydrolyzed to florfenicol or the respective florfenicol analog in vivo, upon administration to an animal.
Type:
Grant
Filed:
December 20, 2004
Date of Patent:
December 26, 2006
Assignee:
Schering-Plough Animal Health Corporation
Inventors:
Scott Hecker, Sunil V. Pansare, Tomasz W Glinka
Abstract: The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a host cells transformed with CD80-encoding vectors, CD86-encoding vectors, CD28-encoding vectors, or CTLA-4-encoding vectors. The invention provides polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4.
Type:
Grant
Filed:
April 30, 1999
Date of Patent:
July 18, 2006
Assignees:
Schering-Plough Animal Health Corporation, The Texas A & M University System
Inventors:
Ellen W. Collisson, InSoo Choi, Barbara J. Winslow, Mark D. Cochran
Abstract: The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
Type:
Grant
Filed:
April 8, 2003
Date of Patent:
May 9, 2006
Assignee:
Schering-Plough Animal Health Corporation
Inventors:
Constantine G. Boojamra, Lee S. Chong, Scott J. Hecker, Tomasz W. Glinka, Dale E. Shuster
Abstract: Novel formulations containing a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol, and methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease.
Type:
Application
Filed:
May 28, 2004
Publication date:
December 2, 2004
Applicant:
SCHERING-PLOUGH ANIMAL HEALTH CORPORATION
Inventors:
Keith A. Freehauf, Allan Weingarten, Robert D. Simmons, Kanwal Jit Varma
Abstract: Novel formulations combining a non-steroidal anti-inflammatory drug (NSAID) such as flunixin, with a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol are disclosed. Methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease and swine respiratory disease, are also disclosed.
Type:
Grant
Filed:
January 24, 2003
Date of Patent:
September 14, 2004
Assignee:
Schering-Plough Animal Health Corporation
Inventors:
Raul E. Kohan, Kanwal J. Varma, Robert D. Simmons, Abu Huq, Keith A. Freehauf
Abstract: The present application relates to osteopontin (Eta-1) polypeptides, nucleic acids that encode Eta-1, antibodies that specifically bind to Eta-1, and methods for enhancing an immune response in an animal.
Type:
Application
Filed:
May 22, 2003
Publication date:
February 5, 2004
Applicant:
Schering-Plough Animal Health Corporation
Abstract: A solvent system for pyrethroids and pyrethrins comprises a terpene or a terpene derivative such as a terpene alcohol, aldehyde or ketone. In a preferred embodiment, the solvent system further comprises an alkylene glycol ether. Compositions comprising pyrethroids and/or pyrethrins in such a solvent system do not crystallize at cold temperatures and have increased efficacy compared to formulations containing conventional solvents.
Type:
Grant
Filed:
February 6, 2002
Date of Patent:
December 9, 2003
Assignee:
Schering-Plough Animal Health Corporation
Abstract: Novel formulations combining a non-steroidal anti-inflammatory drug (NSAID) such as flunixin, with a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol are disclosed. Methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease and swine respiratory disease, are also disclosed.
Type:
Application
Filed:
January 24, 2003
Publication date:
November 27, 2003
Applicant:
Schering-Plough Animal Health Corporation
Inventors:
Raul E. Kohan, Kanwal J. Varma, Robert D. Simmons, Abu Huq, Keith A. Freehauf