Patents Assigned to Scientist of Fortune, S.A.
-
Patent number: 9873895Abstract: The present invention relates to a method for generating 1,3-diene compounds through a biological process. More specifically, the invention relates to a method for producing 1,3-diene compounds (for example butadiene or isoprene) from molecules of the 3-hydroxyalk-4-enoate type or from 3-phosphonoxyalk-4-enoates.Type: GrantFiled: December 18, 2012Date of Patent: January 23, 2018Assignee: Scientist of Fortune S.A.Inventor: Philippe Marliere
-
Patent number: 9850504Abstract: Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.Type: GrantFiled: July 2, 2014Date of Patent: December 26, 2017Assignees: Scientist of Fortune, S.A., Global BioenergiesInventors: Philippe Marliere, Maria Anissimova, Mathieu Allard
-
Publication number: 20170321229Abstract: Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of prenol into isoprene, methods for the production of isoprene using such enzyme variants and their uses in the production of isoprene from prenol.Type: ApplicationFiled: November 12, 2015Publication date: November 9, 2017Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Sabine MAZALEYRAT, Marc DELCOURT, Philippe MARLIÈRE
-
Patent number: 9803220Abstract: The application describes a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene, isoamylene, butadiene or isoprene) from 3-hydroxy-1-carboxylic acids via 3-sulfonyloxy-1-carboxylic acids.Type: GrantFiled: October 24, 2013Date of Patent: October 31, 2017Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Philippe Marliere, Maria Anissimova, Mathieu Allard
-
Publication number: 20170260548Abstract: Described is a method for the production of isobutene from 3-methylcrotonyl-CoA comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyric acid; and (b) further enzymatically converting the thus produced 3-methylbutyric acid into isobutene. The conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyryl-CoA and further enzymatically converting the thus produced 3-methylbutyryl-CoA into 3-methylbutyric acid. Alternatively, the conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylcrotonic acid and then further enzymatically converting the thus produced 3-methylcrotonic acid into 3-methylbutyric acid.Type: ApplicationFiled: September 16, 2015Publication date: September 14, 2017Applicants: Scientist of Fortune, S.A., Global BioenergiesInventors: Philippe Marlière, Mathieu Allard
-
Publication number: 20170253896Abstract: Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyric acid comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid.Type: ApplicationFiled: September 16, 2015Publication date: September 7, 2017Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Philippe MARLIERE, Maria ANISSIMOVA, Mathieu ALLARD
-
Publication number: 20170175147Abstract: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.Type: ApplicationFiled: February 27, 2017Publication date: June 22, 2017Applicant: Scientist of Fortune, S.A.Inventor: Philippe Marlière
-
Publication number: 20170107546Abstract: Described is a method for the enzymatic production of acetyl phosphate from formaldehyde using a phosphoketolase or a sulfoacetaldehyde acetyltransferase.Type: ApplicationFiled: March 13, 2015Publication date: April 20, 2017Applicant: SCIENTIST OF FORTUNE S.A.Inventor: Philippe Marliere
-
Patent number: 9617564Abstract: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.Type: GrantFiled: January 28, 2015Date of Patent: April 11, 2017Assignee: Scientist of Fortune, S.A.Inventor: Philippe Marliere
-
Patent number: 9556460Abstract: Described is a method for the production of 3-hydroxy-3-methylbutyric acid by enzyme-catalyzed covalent bond formation between the carbon atom of the oxo group of acetone and the methyl group of a compound which provides an activated acetyl group. Also described are recombinant organisms which produce 3-hydroxy-3-methylbutyric acid, and related compositions and methods.Type: GrantFiled: March 14, 2015Date of Patent: January 31, 2017Assignee: Scientist of Fortune, S.A.Inventor: Philippe Marliere
-
Patent number: 9453244Abstract: The present invention relates to a method for producing a monoalkene comprising the step of enzymatically converting an alkyl monoester. The conversion preferably makes use of an enzyme which belongs to the group of terpene synthases or to the family of prenyltransferases. Moreover, the present invention relates to the use of a terpene synthase or of a prenyltransferase for enzymatically converting an alkyl monoester into a monoalkene.Type: GrantFiled: June 28, 2013Date of Patent: September 27, 2016Assignees: Global Bioenergies, Scientist of Fortune S.A.Inventors: Philippe Marlière, Maria Anissimova, Mathieu Allard
-
Patent number: 9249430Abstract: Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.Type: GrantFiled: July 12, 2012Date of Patent: February 2, 2016Assignee: Scientist of Fortune, S.A.Inventor: Philippe Marliere
-
Patent number: 9193978Abstract: The present invention relates to a method for generating alkenes through a biological process. More specifically, the invention relates to a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene or isoamylene) from molecules of the 3-hydroxyalkanoate type.Type: GrantFiled: October 18, 2011Date of Patent: November 24, 2015Assignees: Scientist of Fortune, S.A., Global BioenergiesInventors: Marc Delcourt, Maria Anissimova, Richard Tallon, Philippe Marlière
-
Patent number: 9169496Abstract: Described is a method for the enzymatic production of butadiene which allows to produce butadiene from crotyl alcohol. Also described are enzyme combinations and compositions containing such enzyme combinations which allow the enzymatic conversion of crotyl alcohol into butadiene. Furthermore, the invention relates to microorganisms which have been genetically modified so as to be able to produce butadiene from crotyl alcohol. Moreover, the invention relates to a method for the enzymatic production of crotyl alcohol from crotonyl-Coenzyme A. The obtained crotyl alcohol can be further converted into butadiene as described herein. Also described are enzyme combinations which allow to convert crotonyl-Coenzyme A into crotyl alcohol as well as (micro)organisms which express such enzyme combinations.Type: GrantFiled: October 18, 2012Date of Patent: October 27, 2015Assignee: Scientist of Fortune, S.A.Inventor: Philippe Marliere
-
Publication number: 20150159177Abstract: The present invention relates to a method for producing a monoalkene comprising the step of enzymatically converting an alkyl monoester. The conversion preferably makes use of an enzyme which belongs to the group of terpene synthases or to the family of prenyltransferases. Moreover, the present invention relates to the use of a terpene synthase or of a prenyltransferase for enzymatically converting an alkyl monoester into a monoalkene.Type: ApplicationFiled: June 28, 2013Publication date: June 11, 2015Applicants: GLOBAL BIOENERGIES, SCIENTIST OF FORTUNE S.A.Inventors: Philippe Marlière, Maria Anissimova, Mathieu Allard
-
Patent number: 9017977Abstract: Described is a method for the production of 3-hydroxy-3-methylbutyric acid by enzyme-catalyzed covalent bond formation between the carbon atom of the oxo group of acetone and the methyl group of a compound which provides an activated acetyl group. Also described are recombinant organisms which produce 3-hydroxy-3-methylbutyric acid, and related compositions and methods.Type: GrantFiled: September 14, 2010Date of Patent: April 28, 2015Assignee: Scientist of Fortune S.A.Inventor: Philippe Marlière
-
Patent number: 8975050Abstract: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.Type: GrantFiled: March 3, 2014Date of Patent: March 10, 2015Assignee: Scientist of Fortune, S.A.Inventor: Phillippe Marliere
-
Patent number: 8895278Abstract: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.Type: GrantFiled: April 9, 2014Date of Patent: November 25, 2014Assignee: Scientist of Fortune, S.A.Inventor: Phillippe Marliere
-
Publication number: 20140256009Abstract: Described is a method for the enzymatic production of butadiene which allows to produce butadiene from crotyl alcohol. Also described are enzyme combinations and compositions containing such enzyme combinations which allow the enzymatic conversion of crotyl alcohol into butadiene. Furthermore, the invention relates to microorganisms which have been genetically modified so as to be able to produce butadiene from crotyl alcohol. Moreover, the invention relates to a method for the enzymatic production of crotyl alcohol from crotonyl-Coenzyme A. The obtained crotyl alcohol can be further converted into butadiene as described herein. Also described are enzyme combinations which allow to convert crotonyl-Coenzyme A into crotyl alcohol as well as (micro)organisms which express such enzyme combinations.Type: ApplicationFiled: October 18, 2012Publication date: September 11, 2014Applicant: SCIENTIST OF FORTUNE, S.A.Inventor: Philippe Marliere
-
Publication number: 20140248669Abstract: Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.Type: ApplicationFiled: July 12, 2012Publication date: September 4, 2014Applicant: SCIENTIST OF FORTUNE, S.A.Inventor: Philippe Marliere