Patents Assigned to Scipps Clinic and Research Foundation
  • Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
    Patent number: 5238919
    Abstract: This invention provides a peptide fragment of human von Willebrand Factor (vWF) and sub-fragment thereof isolated as enzymtic digestion products from naturally occurring human vWF, or isolated from synthetic peptide mixtures or isolated from lysates of organisms capable of producing recombinant human vWF. The fragments and sub-fragments are useful in the prevention and treatment of cardiovascular disorders by virtue of their ability to inhibit the binding of vWF to platelets, heparin and/or collagen.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: August 24, 1993
    Assignee: Scipps Clinic and Research Foundation
    Inventors: Theodore S. Zimmerman, Yoshihiro Fujimura, Richard A. Houghten, Zaverio M. Ruggeri