Patents Assigned to Scotia Holdings PLC
  • Publication number: 20040071762
    Abstract: Niacin in the form of a topical preparation, both as such and when incorporated in devices for application to the skin; the devices themselves; diagnosis or monitoring of schizophrenia using the preparations or devices; and manufacture of medicaments for such monitoring and diagnosis.
    Type: Application
    Filed: March 10, 2003
    Publication date: April 15, 2004
    Applicant: Scotia Holdings PLC
    Inventors: Alexander Iain Munro Glen, Pauline Elizabeth Ward, David Frederick Horrobin
  • Publication number: 20040048927
    Abstract: This invention relates to the treatment of a disorder selected from the group consisting of Alzheimer's disease and other dementias, and tardive dyskinesia by administering a composition of essential fatty acids of eicosapentaenoic acid (EPA) and stearidonic acid (SA).
    Type: Application
    Filed: July 11, 2003
    Publication date: March 11, 2004
    Applicant: Scotia Holdings PLC
    Inventor: David Frederick Horrobin
  • Publication number: 20040014810
    Abstract: A pharmaceutical preparation for the treatment of schizophrenia and/or tardive dyskinesia using an oil comprising eicosapentaenoic acid (EPA) and/or stearidonic acid (SA) in amounts of more than 20%, preferably more than 40% and very preferably more than 70% by weight of the total (preferably of the total unsaturated) fatty acids present.
    Type: Application
    Filed: May 2, 2003
    Publication date: January 22, 2004
    Applicant: Scotia Holdings PLC.
    Inventor: David Frederick Horrobin
  • Patent number: 6624195
    Abstract: This invention relates to the treatment of depression by administering a composition of essential fatty acids of eicosapentaenoic (EPA) and steraridonic (SA) acids.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: September 23, 2003
    Assignee: Scotia Holdings PLC.
    Inventor: David Frederick Horrobin
  • Patent number: 6610740
    Abstract: A nutritional, cosmetic or pharmaceutical formulation comprising esters of polyethylene glycol in which the polyethylene glycol chain is terminated at one end by a polyunsaturated fatty acyl group, preferably C18-C22 and at the other end by a C1-C4 alkyl group, preferably a methyl group.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: August 26, 2003
    Assignee: Scotia Holdings PLC
    Inventors: Paul Andrew Wakefield, Philip Knowles, Mehar Singh Manku, David Frederick Horrobin
  • Patent number: 6555700
    Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: April 29, 2003
    Assignee: Scotia Holdings plc
    Inventors: David Frederick Horrobin, Mehar Manku, Austin McMordie, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield
  • Publication number: 20030045578
    Abstract: A pharmaceutical preparation for the treatment of schizophrenia and/or tardive dyskinesia using an oil comprising eicosapentaenoic acid (EPA) and/or stearidonic acid (SA) in amounts of more than 20%, preferably more than 40% and very preferably more than 70% by weight of the total (preferably of the total unsaturated) fatty acids present.
    Type: Application
    Filed: September 18, 2001
    Publication date: March 6, 2003
    Applicant: SCOTIA HOLDINGS PLC
    Inventor: David Frederick Horrobin
  • Patent number: 6517883
    Abstract: A food composition giving a prolonged feeling of satiety, comprising a mixture of or an oil-in-water emulsion of triglyceride oils having a solid fat content at ambient or body temperature with a food emulsifier. The invention also refers to the use of said mixture or oil-in-water emulsion for the preparation of a pharmaceutical composition for the control of calorie or fat intake.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: February 11, 2003
    Assignee: Scotia Holdings PLC
    Inventors: Bengt Herslof, Lars Lindmark, Karin Bohlinder, Anders Carlsson
  • Publication number: 20020065319
    Abstract: A pharmaceutical preparation for the treatment of schizophrenia and/or tardive dyskinesia using an oil comprising eicosapentaenoic acid (EPA) and/or stearidonic acid (SA) in amounts of more than 20%, preferably more than 40% and very preferably more than 70% by weight of the total (preferably of the total unsaturated) fatty acids present.
    Type: Application
    Filed: September 18, 2001
    Publication date: May 30, 2002
    Applicant: SCOTIA HOLDINGS PLC
    Inventor: David Frederick Horrobin
  • Patent number: 6331568
    Abstract: A pharmaceutical preparation for the treatment of schizophrenia and/or tardive dyskinesia using an oil comprising eicosapentaenoic acid (EPA) and/or stearidonic acid (SA) in amounts of more than 20%, preferably more than 40% and very preferably more than 70% by weight of the total (preferably of the total unsaturated) fatty acids present.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: December 18, 2001
    Assignee: Scotia Holdings PLC.
    Inventor: David Frederick Horrobin
  • Patent number: 6245811
    Abstract: Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R2 is as R1 the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R3 is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C1-C4 alkyl group.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: June 12, 2001
    Assignee: Scotia Holdings PLC
    Inventors: David Frederick Horrobin, Mehar Manku, Austin McMordie, Philip Knowles, Peter Redden, Andrea Pitt
  • Patent number: 6184251
    Abstract: This invention relates to the administration of arachidonic acid or docosahexaenoic acid or precursors thereof to children or pregnant women for the treatment or prevention of dyspraxia.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: February 6, 2001
    Assignee: Scotia Holdings PLC
    Inventors: Barbara Jacqueline Stordy, David F. Horrobin
  • Patent number: 6177470
    Abstract: Optimum conditions for prostaglandin synthesis are provided by internally administering an ascorbic-6-acid ester of gamma-linolenic acid or an ascorbic-6-acid ester of dihomo-gamma-linolenic acid.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: January 23, 2001
    Assignee: Scotia Holdings PLC
    Inventors: David F Horrobin, Philip Knowles, Mehar S Manku
  • Patent number: 6069168
    Abstract: Use of 6-desaturated n-6 fatty acids, especially gammalinolenic acid (GLA), dihomogammalinolenic acid (DGLA) or arachidonic acid (AA), together with a pharmaceutically acceptable material reducing intracellular levels of sorbitol in the body, particularly an aldose reductase inhibitor, in the treatment of (including prophylactic treatment), and in the preparation of medicaments for the treatment of (including prophylactic treatment), the long-term complications of diabetes mellitus. Pharmaceutical compositions of said materials. The ascorbate esters of 6-desaturated n-6 fatty acids (other than GLA or DGLA) per se.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: May 30, 2000
    Assignee: Scotia Holdings Plc
    Inventors: David Frederick Horrobin, Mary Cotter, Norman Cameron
  • Patent number: 5990164
    Abstract: An N-alkylpolyhydroxyamine salt of an n-6 or n-3 essential fatty acid (EFA) that is beyond the 6-desaturation step, or of any polyunsaturated fatty acid, other than those belonging to the n-6 and n-3 series, having 16 to 26 carbon atoms and up to six double bonds, the double bonds being in the cis or trans configuration, the salt being formed with the fatty acid either as such or in the form of a covalent derivative, through the carboxyl group, of a bifunctional compound itself having a free acid function.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: November 23, 1999
    Assignee: Scotia Holdings PLC
    Inventors: David F. Horrobin, Philip Knowles, Mehar Manku, John C. Stewart
  • Patent number: 5922345
    Abstract: Countering side effects of parenteral or fluid-diet enteral nutrition by adding one or more 6-desaturated essential fatty acids (EFAs) to parenteral or enteral composition (particularly low-fat compositions) being given, or giving them in addition to the compositions.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: July 13, 1999
    Assignee: Scotia Holdings Plc
    Inventors: David F. Horrobin, Lars Lindmark
  • Patent number: 5888541
    Abstract: Increase gut calcium absorption in humans or animals by the administration of GLA, DGLA or LA as such or in salt or other pharmacologically acceptable form, optionally in association with EPA, DHA or other EFA in similar forms, specifically useful in the treatment of osteoporosis.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: March 30, 1999
    Assignee: Scotia Holdings PLC
    Inventors: David F. Horrobin, Brenda E. Reynolds
  • Patent number: 5871757
    Abstract: Polyunsaturated oils such as triply or higher ethylenically unsaturated organic materials are stabilized against ambient temperature atmospheric oxidation by the addition of an essential oil such as thyme oil, oregano oil, pepper oil or clove oil.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: February 16, 1999
    Assignee: Scotia Holdings PLC
    Inventors: John B. Cloughley, David F Horrobin
  • Patent number: 5866703
    Abstract: Triglycerides with at least two different acids chosen from 6-desaturated essential fatty acids and oleic acid, useful in nutrition and in medicine.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: February 2, 1999
    Assignee: Scotia Holdings PLC
    Inventors: David F. Horrobin, Austin McMordie, Mehar Singh Manku, Philip Knowles
  • Patent number: 5859055
    Abstract: Gamma-linolenic acid and/or dihomo-gamma-linolenic acid is used in the preparation of a medicament for inhibiting reocclusion of an artery from which an occlusion or other blockage has been removed, or for preventing occlusion of peripheral or coronary arteries. The medicament may also comprise eicosapentaenoic acid.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: January 12, 1999
    Assignee: Scotia Holdings PLC
    Inventors: David F. Horrobin, John C. M. Stewart