Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.
Type:
Application
Filed:
July 27, 2012
Publication date:
October 16, 2014
Applicant:
Sea Lane Biotechnologies, LLC
Inventors:
Ramesh R. Bhatt, Pamela K. Foreman, Lawrence C. Horowitz, Michael Horowitz, Medini Gore, Phil Kobel
Abstract: The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.
Abstract: The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of H1, H2, H3, H5, H7 and H9, such as, for example all of H1, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.
Type:
Application
Filed:
September 13, 2013
Publication date:
July 24, 2014
Applicant:
Sea Lane Biotechnologies, LLC
Inventors:
Lawrence Horowitz, Ramesh Bhatt, Arun K. Kashyap
Abstract: The present invention concerns methods and means for identifying, producing, and engineering neutralizing agents against influenza A viruses, and to the neutralizing agents produced. In particular, the invention concerns neutralizing agents against various influenza A virus subtypes, and methods and means for making such agents.
Type:
Application
Filed:
November 17, 2011
Publication date:
July 17, 2014
Applicant:
SEA LANE BIOTECHNOLOGIES, LLC
Inventors:
Lawrence Horowitz, Ramesh R. Bhatt, Arun K. Kashyap
Abstract: The present invention concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present invention also concerns the method of making and using the donor-specific antibodies. The present invention further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease.
Type:
Grant
Filed:
September 11, 2007
Date of Patent:
April 3, 2012
Assignee:
Sea Lane Biotechnologies, LLC
Inventors:
Lawrence Horowitz, Ramesh Bhatt, Arun K. Kashyap
Abstract: The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof.
Type:
Grant
Filed:
September 28, 2007
Date of Patent:
March 6, 2012
Assignee:
Sea Lane Biotechnologies LLC
Inventors:
Lawrence Horowitz, Ramesh Bhatt, Aaron L. Kurtzman
Abstract: The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.