Patents Assigned to Secifarma S.p.A.
  • Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one
    Patent number: 5955635
    Abstract: An improved process for the preparation of Nabumetone, which comprises the following steps:a) condensation between 6-methoxy-naphthaldehyde I and t-butyl acetoacetate II, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2'-naphthyl)-but-3-en-2-one III as an E/Z mixture;b) hydrogenation of III in the presence of a palladium catalyst, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2-naphthyl)-butan-2-one IV;c) cleavage of the t-butyl ester by acid catalysis; andd) recrystallization of the crude with methanol.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: September 21, 1999
    Assignee: Secifarma S.P.A.
    Inventors: Walter Cabri, Domenico Magrone, Roberto Angelini, Erminio Oldani
  • Process for the industrial preparation of aminoacetylenes
    Patent number: 5902902
    Abstract: A process for the preparation of 3-aminophenylacetylene derivatives of formula: ##STR1## wherein R.sub.1 is as defined in the disclosure ##STR2## wherein Y is as defined in the disclosureR--C.tbd.C--Hwherein R is as defined in the disclosure.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: May 11, 1999
    Assignee: Secifarma S.p.A.
    Inventors: Walter Cabri, Erminio Oldani
  • Process for the resolution of (+)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the corresponding enantiomers
    Patent number: 4625054
    Abstract: An improved process for the resolution of (+)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the corresponding enantiomers by using L-threo-(+)-2-amino-1-(4-nitrophenyl)-1,3-propanediol and L-threo-(+)-2-amino-1-(4-methylmercaptophenyl)-1,3-propanediol.
    Type: Grant
    Filed: October 11, 1985
    Date of Patent: November 25, 1986
    Assignee: Secifarma S.p.A.
    Inventor: Giuseppe Bernini
  • Process for the enantiomeric resolution of mixtures of D and L-6-methoxy-alpha-methyl-2-naphthaleneacetic acid and resolving agent for said process
    Patent number: 4621152
    Abstract: The invention relates to a process for the resolution of mixtures of D and L-6-methoxy-alpha-methyl-2-naphthaleneacetic acid in their respective antipodes.L-threo(+)-2-amino-1-p-nitrophenyl-1,3-propandiol is proposed as new resolving agent.
    Type: Grant
    Filed: February 22, 1984
    Date of Patent: November 4, 1986
    Assignee: Secifarma S.p.A.
    Inventor: Giuseppe Bernini