Patents Assigned to SEED RESEARCH INSTITUTE CO., LTD.
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Patent number: 11753385Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: October 6, 2021Date of Patent: September 12, 2023Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20220024883Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: October 6, 2021Publication date: January 27, 2022Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 11155526Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: October 26, 2021Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 11066374Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: July 20, 2021Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10980813Abstract: Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein ring A is an optionally further substituted 5- to 7-membered heterocycle, and the 5- to 7-membered heterocycle is optionally condensed with 1 or 2 rings selected from an optionally substituted benzene ring and an optionally substituted 5- to 7-membered heterocycle, X is —N?, —NR2— or —O—; Y1 is a hydrogen atom, and Y2 is a hydroxy group or Y1 and Y2 may be joined to form a bond or —O—; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and R2 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof as an active ingredient.Type: GrantFiled: February 27, 2018Date of Patent: April 20, 2021Assignee: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10703732Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: July 7, 2020Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10618876Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: April 14, 2020Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20190216820Abstract: Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein ring A is an optionally further substituted 5- to 7-membered heterocycle, and the 5- to 7-membered heterocycle is optionally condensed with 1 or 2 rings selected from an optionally substituted benzene ring and an optionally substituted 5- to 7-membered heterocycle, X is —N?, —NR2— or —O—; Y1 is a hydrogen atom, and Y2 is a hydroxy group or Y1 and Y2 may be joined to form a bond or —O—; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and R2 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof as an active ingredient.Type: ApplicationFiled: February 27, 2018Publication date: July 18, 2019Applicant: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190152929Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: May 23, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023669Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023667Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023668Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 10106509Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: February 26, 2016Date of Patent: October 23, 2018Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 9988396Abstract: Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H)(R6)— or —C(H)(R7)—C(H)(R8)—; and R1-R8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.Type: GrantFiled: January 26, 2017Date of Patent: June 5, 2018Assignee: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 9896457Abstract: Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.Type: GrantFiled: August 29, 2014Date of Patent: February 20, 2018Assignees: OP Bio Factory Co., Ltd., Seed Research Institute Co., Ltd.Inventors: Morita Iwami, Sachi Kato, Yoshimi Matsumoto, Hideo Naoki
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Publication number: 20180037555Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: February 26, 2016Publication date: February 8, 2018Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20170327513Abstract: Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H) (R6)— or —C(H) (R7)—C(H)(R8)—; and R1-R8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.Type: ApplicationFiled: January 26, 2017Publication date: November 16, 2017Applicant: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20160207937Abstract: Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.Type: ApplicationFiled: August 29, 2014Publication date: July 21, 2016Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Morita IWAMI, Sachi KATO, Yoshimi MATSUMOTO, Hideo NAOKI