Abstract: An imaging system includes a shutter, an array of photodetectors, and electronic circuitry associated with the photodetectors to read intensity values from the photodetectors, the electronic circuitry including elements configured to provide an operating bias point of the photodetectors. The imaging system includes components, such as a controller, configured to adaptively adjust the operating bias for the photodetectors wherein the adjustment is based at least in part on intermittent measurement of a flat field image. During use, the imaging system can be configured to perform intermittent adjustments of the operating bias based on changes in photodetector values for intermittently acquired flat field images. Adjustment of the operating bias may provide compensation for drift over time of the photodetectors and/or electronics due to effects including but not limited to temperature changes.

Abstract: In some embodiments, methods or systems may be provided for an imaging system including an imaging sensor, wherein frames or sub-frames of intensity data may be acquired from some or all pixels of the frame, and a moving kernel, smaller than the frame or sub-frame, is moved over the frame for analysis. The values of the center column of the kernel may be compared to the outer column values of the kernel and a column offset for the center column may be determined. Only one offset value may be stored at any one time for each pixel in the frame or sub-frame.