Abstract: Disclosed are a luminescence biotin-transition metal complex conjugate and a method of amplifying signals using the same. More particularly, disclosed herein are a luminescence biotin-transition metal complex conjugate comprising an energy acceptor and biotin, and optionally an energy donor and a method of amplifying signals using the biotin-transition metal complex conjugate using intramolecular energy transfer. The luminescence biotin-transition metal complex conjugate using a transition metal probe provides a phosphorescence detection system capable of improved sensitivity.
Type:
Grant
Filed:
February 12, 2009
Date of Patent:
February 28, 2012
Assignees:
Samsung Electronics Co., Ltd., Seoul National Univeristy Industry Foundation
Inventors:
Tae-hyuk Kwon, Jong-chul Kwon, Jong-in Hong
Abstract: Provided is a method for screening a biological molecule rapidly and economically with high-throughput using microbeads encoded with silver nanoparticles and a chemical compound and dielectrophoresis. A biological screening method particularly utilizes microbeads encoded with silver nanoparticles and a specific chemical compound and dielectrophoresis. Since this screening method does not use a fluorescent material and a dying agent, which are typically used in the conventional screening method, it is non-toxic and economical. Also, this screening method allows simultaneous identification of many target materials. Accordingly, a leading compound can be screened within a short period of time, and thus, this screening method can be implemented as an economical and effective system for developing new pharmaceutical products.
Type:
Application
Filed:
September 15, 2006
Publication date:
March 25, 2010
Applicant:
Seoul National Univeristy Industry Foundation
Inventors:
Yoon-Sik Lee, Yong-Kweon Kim, Dae-Hong Jeong, Jong-Ho Kim, Min-Soo Kim, Hee-Jeong Choi, Bong-Hyun Jun