Patents Assigned to Sequoia Sciences, Inc.
  • Patent number: 10137192
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: April 8, 2018
    Date of Patent: November 27, 2018
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 10058608
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: October 8, 2017
    Date of Patent: August 28, 2018
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9878037
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: January 30, 2018
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9562031
    Abstract: The present invention generally relates to phenethyldihydrobenzodioxolone compounds and compositions useful for reducing or inhibiting tumor growth. It also relates to methods of use and the preparation of phenethyldihydrobenzodioxolone compounds.
    Type: Grant
    Filed: September 12, 2015
    Date of Patent: February 7, 2017
    Assignee: Sequoia Sciences, Inc.
    Inventors: Russell B Williams, Gary Eldridge, Courtney M. Starks, Peter Robert Guzzo, Zhongping Huang
  • Patent number: 9504743
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: November 29, 2016
    Assignee: Sequoia Sciences, Inc
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9492522
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: November 15, 2016
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9415101
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: August 16, 2016
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9415097
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: August 16, 2016
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M. Martin
  • Patent number: 9149521
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: October 6, 2015
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9149522
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: October 6, 2015
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Patent number: 9017698
    Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: April 28, 2015
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Steven M Martin
  • Publication number: 20130274256
    Abstract: Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.
    Type: Application
    Filed: October 11, 2012
    Publication date: October 17, 2013
    Applicant: SEQUOIA SCIENCES, INC.
    Inventor: Sequoia Sciences, Inc.
  • Patent number: 8324264
    Abstract: Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: December 4, 2012
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary R. Eldridge, Ronald Neil Buckle, Michael Ellis, Zhongping Huang, John Edward Reilly
  • Publication number: 20100041753
    Abstract: The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.
    Type: Application
    Filed: October 8, 2009
    Publication date: February 18, 2010
    Applicant: SEQUOIA SCIENCE, INC.
    Inventor: Gary R. Eldridge
  • Publication number: 20100004480
    Abstract: The present invention discloses compounds, compositions, and methods of using such compounds and compositions to inhibit, reduce, prevent, and remove biofilms. The invention further relates to methods of inhibiting biofilms on various substrates, such as medical devices.
    Type: Application
    Filed: August 3, 2009
    Publication date: January 7, 2010
    Applicant: Sequoia Sciences, Inc.
    Inventors: Gary R. Eldridge, Jin-Feng Hu
  • Patent number: 7612045
    Abstract: The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention are pentacyclic acid triterpenes. Methods for controlling biofilms and for controlling and/or preventing bacterial infections are also disclosed.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: November 3, 2009
    Assignee: Sequoia Sciences, Inc.
    Inventor: Gary R. Eldridge
  • Patent number: 7604978
    Abstract: The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: October 20, 2009
    Assignee: Sequoia Sciences, Inc.
    Inventor: Gary R. Eldridge
  • Publication number: 20090192327
    Abstract: The present invention discloses compounds, compositions, and methods of using such compounds and compositions to inhibit, reduce, prevent, and remove biofilms. The invention further relates to methods of inhibiting biofilms on various substrates, such as medical devices.
    Type: Application
    Filed: December 3, 2008
    Publication date: July 30, 2009
    Applicant: Sequoia Sciences, Inc.
    Inventors: Gary R. Eldridge, Jin-Feng Hu, John W. Costerton, Mark Pasmore
  • Publication number: 20080280770
    Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.
    Type: Application
    Filed: July 2, 2008
    Publication date: November 13, 2008
    Applicant: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Lu Zeng, Peader Cremin, Chris Lee, Helene C. Vervoort, Marilyn Ghanem
  • Patent number: 7367933
    Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: May 6, 2008
    Assignee: Sequoia Sciences, Inc.
    Inventors: Gary Eldridge, Lu Zeng, Peader Cremin, Chris Lee, Helene C. Vervoort, Marilyn Ghanem