Patents Assigned to SETLANCE S.R.L.
  • Methods for removing bacterial toxins from a biological fluid
    Patent number: 11104705
    Abstract: Methods for removing bacterial toxins such as lipopolysaccharide and lipoteichoic acid from a biological fluid with a peptide selected from KKIRVRLSA (SEQ ID NO:1), RRIRVRLSA (SEQ ID NO:2), KRIRVRLSA (SEQ ID NO:3) and RKIRVRLSA (SEQ ID NO:4), the peptide being covalently attached to a solid support through the C-terminus, optionally with the interposition of a linker.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: August 31, 2021
    Assignee: SETLANCE S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci, Jlenia Brunetti, Leila Quercini
  • METHODS FOR REMOVING BACTERIAL TOXINS FROM A BIOLOGICAL FLUID
    Publication number: 20200048307
    Abstract: This invention relates to methods for removing bacterial toxins such as lipopolysaccharide and lipoteichoic acid from a biological fluid. In such method a peptide, selected from the list of KKIRVRLSA, RRIRVRLSA, KRIRVRLSA and RKIRVRLSA, is covalently attached to a solid support through its C-terminus, optionally with the interposition of a linker, and is used to capture the toxins. This invention also relates to such derivatised solid supports and to cartridges, columns, and medical apparatuses comprising such derivatised solid supports.
    Type: Application
    Filed: April 19, 2018
    Publication date: February 13, 2020
    Applicant: SETLANCE S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci, Jlenia Brunetti, Leila Quercini
  • THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20190388494
    Abstract: There are disclosed therapeutic combinations of an antibacterial peptide and an antibiotic drug for use in the treatment of infections caused by Gram-negative pathogens, including bacterial strains resistant to common antibiotics. Also disclosed are pharmaceutical preparations and compositions containing the antibacterial peptide and antibiotics.
    Type: Application
    Filed: January 24, 2018
    Publication date: December 26, 2019
    Applicant: SETLANCE S.R.L.
    Inventors: Chiara Falciani, Alessandro Pini, Luisa Bracci, Jlenia Brunetti, GianMaria Rossolini, Simona Pollini
  • Antimicrobial peptide, branched forms thereof and their use in the treatment of bacteria infections
    Patent number: 8921308
    Abstract: The instant invention refers to an antibacterial peptide with all amino acids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: December 30, 2014
    Assignee: Setlance S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci
  • ANTIMICROBIAL PEPTIDE, BRANCHED FORMS THEREOF AND THEIR USE IN THE TREATMENT OF BACTERIA INFECTIONS
    Publication number: 20130130969
    Abstract: The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
    Type: Application
    Filed: July 11, 2011
    Publication date: May 23, 2013
    Applicant: SETLANCE S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci