Abstract: An antifungal peptide targeting P4-ATPase function is synthesized based on Cdc50 loop region to identify peptides sensitize caspofungin by blocking flippase function. It was found that myristylated peptides based on “AS15 sequence” was effective at high concentrations. A modified peptide, “AW9-Ma” showed minimum inhibitory concentration (MIC) of 64 ?g/mL against H99 wild type and fractional inhibitory concentration (FIC) index value of 0.5 when used with caspofungin. With the AW9-Ma peptide, C. neoformans wild type was highly sensitive to caspofungin with a MIC of 4 ?g/mL, the same as cdc50? mutant. Further assays with flow cytometry showed inhibition of lipid flippase enzyme activity and significant accumulation of phosphatidylserine on the cell surface. It was confirmed that the peptide co-localized with mCherry-tagged P4-ATPase protein Apt1 in C. neoformans.

Abstract: An antifungal peptide targeting P4-ATPase function is synthesized based on Cdc50 loop region to identify peptides sensitize caspofungin by blocking flippase function. It was found that myristylated peptides based on “AS15 sequence” was effective at high concentrations. A modified peptide, “AW9-Ma” showed minimum inhibitory concentration (MIC) of 64 ?g/mL against H99 wild type and fractional inhibitory concentration (FIC) index value of 0.5 when used with caspofungin. With the AW9-Ma peptide, C. neoformans wild type was highly sensitive to caspofungin with a MIC of 4 ?g/mL, the same as cdc50? mutant. Further assays with flow cytometry showed inhibition of lipid flippase enzyme activity and significant accumulation of phosphatidylserine on the cell surface. It was confirmed that the peptide co-localized with mCherry-tagged P4-ATPase protein Apt1 in C. neoformans.

Abstract: Photoactive polymer coatings and methods of making the same are disclosed herein. In some embodiments, a polymer coating having a porous structure extending throughout the polymer coating, wherein the porous structure is present at an exposed surface of the polymer coating creating a roughened surface, wherein the polymer of the polymer coating is a siloxane based polymer; and a modified support particle disposed within the polymer coating, wherein the modified support particle includes a substituted phthalocyanine and a support particle. In some embodiments, the substituted phthalocyanine is a halogenated phthalocyanine.

Abstract: Photoactive polymer coatings and methods of making the same are disclosed herein. In some embodiments, a polymer coating comprises a polymer matrix having a porous structure extending throughout the polymer matrix, wherein the porous structure is present at an exposed surface of the polymer coating creating a roughened surface, and a modified support particle disposed within the polymer matrix, wherein the modified support particle includes a substituted phthalocyanine and a support particle. In some embodiments, the substituted phthalocyanine is a halogenated phthalocyanine.

Abstract: Methods and apparatus for detecting an analyte using fluorinated phthalocyanines is disclosed herein. A method for detecting an analyte includes illuminating an analyte solution which contacts an electrode comprising a conductive material having a photosensitizer coupled thereto to generate a reactive oxygen species, wherein the photosensitizer is a fluorinated pthalocyanine having a metal or a non-metal center, oxidizing an analyte present in the analyte solution with the reactive oxygen species to form an oxidized analyte, and detecting a current resulting from the reduction of the oxidized analyte at the electrode.

Abstract: Photoactive polymer coatings and methods of making the same are disclosed herein. In some embodiments, a polymer coating comprises a polymer matrix having a porous structure extending throughout the polymer matrix, wherein the porous structure is present at an exposed surface of the polymer coating creating a roughened surface, and a modified support particle disposed within the polymer matrix, wherein the modified support particle includes a substituted phthalocyanine and a support particle. In some embodiments, the substituted phthalocyanine is a halogenated phthalocyanine.

Abstract: Methods and apparatus for detecting an analyte using fluorinated phthalocyanines is disclosed herein. A method for detecting an analyte includes illuminating an analyte solution which contacts an electrode comprising a conductive material having a photosensitizer coupled thereto to generate a reactive oxygen species, wherein the photosensitizer is a fluorinated pthalocyanine having a metal or a non-metal center, oxidizing an analyte present in the analyte solution with the reactive oxygen species to form an oxidized analyte, and detecting a current resulting from the reduction of the oxidized analyte at the electrode.

Abstract: A new class of organic-inorganic hybrid composite materials, composites of a fluoroalkyl fluorophthalocyanine and a solid-state support containing an imidazole group. The new class of composite materials can be used as a heterogeneous catalyst for the heterogeneous oxidation organic molecules in aqueous and some organic solvents systems is claimed.

Abstract: Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol which causes a phase separation.

Abstract: A process for use of composite catalysts for oxidation of amines during synthesis of energetic compounds. This method overcomes the safety concerns associated with dangerous reaction conditions for these energetic materials. The process requires exposing phthalocyanine conjugated to an inorganic substrate to the precursor reactant and activating the composite material to light and oxygen to covert amine groups into oxidized nitrogen species.

Abstract: Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol which causes a phase separation.

Abstract: Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell.

Abstract: Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol.

Abstract: Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol.

Abstract: Disclosed are cyclopropanated carbohydrate compounds of formulas I and II: Also disclosed are methods of treating or preventing a central nervous system ailment by administering to an organism in need thereof an effective amount of a cyclopropanated carbohydrate compound of formula I or II and pharmaceutical compositions containing a cyclopropanated carbohydrate compound of formula I or II.

Abstract: A supported catalyst comprising a support, an anchoring agent such as an isopoly-oxymetal anion or oxometal salt thereof, and a metal complex which is useful in a wide variety on organic reactions, especially the hydrogenation of substituted .alpha.,.beta. unsaturated acids and esters, is provided. Various methods of preparing the supported catalyst of the present invention is also disclosed.

Abstract: A supported catalyst comprising a support, an anchoring agent such as a heteropoly acid or anion, and a metal complex which is useful in a wide variety on organic reactions, especially the hydrogenation of substituted .alpha., .beta. unsaturated acids and esters, is provided. Various methods of preparing the supported catalyst of the present invention is also disclosed.

Abstract: A supported catalyst comprising a support, an anchoring agent such as a heteropoly acid or anion, and a metal complex which is useful in a wide variety on organic reactions, especially the hydrogenation of substituted .alpha.,.beta. unsaturated acids and esters, is provided. Various methods of preparing the supported catalyst of the present invention is also disclosed.