Abstract: The present disclosure relates to an antibody binding specifically to CD55 or an antigen-binding fragment thereof; and a composition for preventing, treating and/or diagnosing cancer containing the same. The antibody of the present disclosure may be used as an effective therapeutic composition for various CD55-mediated diseases since it shows high binding ability and inhibitory effect for the CD55 protein which promotes tumor growth by inhibiting the complement immune mechanism. In addition, the antibody of the present disclosure may be usefully used as an effective therapeutic adjuvant that fundamentally removes drug resistance and remarkably improves therapeutic responsiveness in various diseases in which resistance to therapeutic agents with CDC (complement-dependent cytotoxicity) as a mechanism of action has been induced due to overexpression of CD55.
Type:
Application
Filed:
January 12, 2022
Publication date:
May 2, 2024
Applicants:
SG MEDICAL INC, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, KOREA ATOMIC ENERGY RESEARCH INSTITUTE
Inventors:
Ji Chul LEE, Hye In PARK, Sung-Won MIN, Sung-Won MIN, Hyeong Sun KWON, Jae Cheong LIM, So Hee DOH, Eun Ha CHO, So-Young LEE, Sung Hee JUNG
Abstract: The present invention relates to a monoclonal antibody or fragment thereof that recognizes and binds specifically to beta 1 integrin as an antigen. The present invention also relates to a pharmaceutical composition for preventing or treating cancer including the monoclonal antibody or fragment thereof.
Type:
Application
Filed:
January 8, 2020
Publication date:
November 24, 2022
Applicant:
SG MEDICAL INC.
Inventors:
Ji Chul LEE, Jongchan PARK, Sung-Won MIN, Hyeong Sun KWON
Abstract: A manufacturing method of a sample collector for collection and transport of biological liquid samples, which includes a supporter, and a collecting part which is formed at an end portion of the supporter and to which fiber yarns are planted, includes the steps of: A) preparing two or more fiber yarns which are different from each other in at least one of length and width; and B) planting each of the fiber yarns to the collecting part based on a flocking method, wherein the step B) comprises the steps of: B1) mixing and putting the fiber yarns into a planting container so that the fiber yarns are distributed evenly; B2) inserting the collecting part into the planting container and applying adhesive onto the surface of the collecting part; and B3) planting the fiber yarns to the collecting part by electrostatic charge of each of the fiber yarns.