Abstract: An neonatal care unit comprising: a hood defining an interior space and having a bottom opening, wherein the hood is dimensioned to accommodate a neonate; a sealing skirt extending along at least a portion of a peripheral edge of the bottom opening and configured to engage at least part of a front torso region of a human in a sealing engagement; at least one access opening located about a sidewall of the hood and dimensioned to allow passage of the neonate therethrough; at least two arm ports located about the sidewall and dimensioned to allow passage of a hand therethrough; and at least one port configured to allow passage of a medical conduit therethrough.

Abstract: A device for perfusing a coronary sinus of a subject's heart which may include: a double-lumen catheter including: a first lumen having: a proximal opening, and a distal opening configured to be positioned in a coronary sinus of a subject's heart; and a second lumen parallel to the first lumen, the second lumen having: a proximal opening, and a distal opening being offset from the distal opening of the first lumen towards the proximal opening of the second lumen in a longitudinal direction, the distal opening of the second lumen being configured to be positioned in a right atrium of the subject's heart; and an oxygenator connected to the proximal openings of the first lumen and the second lumen, the oxygenator is configured to oxygenate deoxygenated blood.

Abstract: A support system for an intraocular lens (IOL) comprising a primary intraocular ring (PIR) mountable to an eye and a secondary device (SD), the SD in communication with the PIR and movable relative to the PIR. The movement can be one or more of rotation, forward-backward movement, decentralization, tilt and angulation. The IOL can be controllably and non-invasively moved relative to the PIR, with the movement being one or more of rotation, forward-backward movement, decentralization, tilt and angulation.

Abstract: An implantable renal replacement therapy device may include: a first catheter configured to be inserted into a blood vessel in a subject's body; a pump in fluid communication with the first catheter, the pump is configured to pump subject's blood from the blood vessel; a filter in fluid communication with the pump, the filter is configured to: receive the subject's blood from the pump, and filter the received blood to provide a filtered blood and a filtrate liquid, wherein the filter is in fluid communication with the first catheter to cause an outflow of the filtered blood from the filter to the blood vessel; and a second catheter in fluid communication with the filter and configured to be inserted into an urinary bladder in the subject's body to cause an outflow of the filtrate liquid from the filter to the urinary bladder.

Abstract: An implantable renal replacement therapy device may include: a first catheter configured to be inserted into a blood vessel in a subject's body; a pump in fluid communication with the first catheter, the pump is configured to pump subject's blood from the blood vessel; a filter in fluid communication with the pump, the filter is configured to: receive the subject's blood from the pump, and filter the received blood to provide a filtered blood and a filtrate liquid, wherein the filter is in fluid communication with the first catheter to cause an outflow of the filtered blood from the filter to the blood vessel; and a second catheter in fluid communication with the filter and configured to be inserted into an urinary bladder in the subject's body to cause an outflow of the filtrate liquid from the filter to the urinary bladder.

Abstract: A subcutaneous sling for neck lift surgery. The sling comprises a sling body, shaped to fit in a submental triangle of a patient undergoing neck lift surgery, comprising a narrow anterior edge for anchoring near the chin of the patient. The sling comprises two lateral sling extensions, each coupled to a respective side edge of two sides of the sling body, each projecting away from the center of the sling body in a posterior lateral orientation of between 45 and 90 degrees from the anterior-posterior axis, and curved slightly towards the narrow anterior edge to fit the submandibular triangle and extend to near each ear of the patient. The sling body is at least 4 centimeters long in the anterior-posterior dimension, and the ends of the two lateral sling extensions are at least 14 centimeters distant from each other.

Abstract: A composition comprising liposomes comprising a lipid layer defining an internal aqueous compartment, an anthracycline drug entrapped in the internal aqueous phase and mitomycin C prodrug incorporated into the lipid layer is described.

Abstract: An endoscopic cuff having an outer surface configured to allow access of the cuff to tight tissue locations, wherein the cuff has a first collapsed configuration and a second expanded configuration; wherein the expanded configuration is configured to allow passage of one or more endoscopic accessory devices through the at least one longitudinal bore.

Abstract: Provided are therapeutic combinations of beta-glycolipides and 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol, as well as compositions, kits and methods using the same in treating disorders associated with protein misfolding and for immunomodulation.

Abstract: The present disclosure provides liposomes comprising a membrane and an intraliposomal aqueous water phase, the membrane comprising at least one liposome forming lipid and the intraliposomal aqueous water phase comprises a salt of a bisphosphonate together with an amphipathic weak base agent (PLAD). An example of a liposome is one comprising co encapsulated in the intraliposomal aqueous water phase N-containing bisphosphonate, such as alendronate, and an anthracycline such as doxorubicin which was shown to increase survival as compared to Doxil or to administrations of liposomal alendronate (PLA) and Doxil (separate liposomes). Such liposomes may carry a targeting moiety exposed at the liposome's outer surface, for example, conjugate of folic acid as a targeting moiety to folate receptor (FT-PLAD). Also provided by the present disclosure is a method of preparing the liposomes and methods of use of the liposomes, at times, in combination with additional active ingredients, such as ?? T-cells.

Abstract: The present invention is based on a finding of an unexpected synergistic and safe combination of antineoplastic agents which when administered in combination provides greater efficacy than the single agents alone. Accordingly, a method of treating neoplasia in a subject in need of treatment is provided, by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with an amount of a chemotherapeutic agent. In one embodiment, the prodrug of mitomycin C is a liposomal-prodrug of mitomycin C. Together, the prodrug of mitomycin C and chemotherapeutic agent provide a synergistic antineoplastic effect.