Patents Assigned to Shandong Holly Pharmaceutical Co., Ltd.
  • Method for preparing amantadine
    Patent number: 11639328
    Abstract: A method for preparing amantadine includes chlorinating adamantane with chlorine gas in a solvent in the presence of a Lewis acid catalyst to obtain a reaction liquid, and then removing the solvent and residues containing the catalyst in the reaction liquid, to obtain a chlorinated product. The chlorinated product is mixed with urea to a mixture, and the mixture is subjected to an amination reaction, to obtain amantadine. The results of examples show that the purity of the prepared amantadine could reach 99.5% or more.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: May 2, 2023
    Assignee: Shandong Holly Pharmaceutical Co., Ltd.
    Inventors: Lanhua Li, Yuenan Qiu, Donghong Xu, Zhiyuan Liu, Huaqiang Wu, Zhufeng Zhou, Lihong Chen, Zhen Lin