Patents Assigned to Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
-
Patent number: 9725452Abstract: The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.Type: GrantFiled: March 14, 2014Date of Patent: August 8, 2017Assignees: Presidents and Fellows of Harvard College, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Tufts University, University of HoustonInventors: Junying Yuan, Alexei Degterev, Gregory D. Cuny
-
Patent number: 9701601Abstract: The present invention relates to an optically active axially chiral ?-allenic alcohol, a synthesis method and use thereof. The invention relates to a method of preparing a highly optically active chiral ?-allenic alcohol by using propargyl alcohol, aldehyde and chiral ?,?-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral ?-allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high.Type: GrantFiled: November 20, 2012Date of Patent: July 11, 2017Assignee: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Shengming Ma, Juntao Ye
-
Publication number: 20170051222Abstract: The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.Type: ApplicationFiled: March 23, 2016Publication date: February 23, 2017Applicant: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: YONG TANG, Wenjie Tao, Xiuli Sun, Junfang Li, Zheng Wang
-
Patent number: 9527862Abstract: Disclosed are aromatic spiroketal diphosphine ligands, preparation methods and uses thereof. The ligands have the structure of formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are defined as such described in the specification. The aromatic spiroketal diphosphine ligands are prepared from aromatic spiroketal compounds. Also disclosed are the preparation methods of aromatic spiroketal compounds. The preparation methods are simple and can produce racemic or chiral aromatic spiroketal diphosphine ligands.Type: GrantFiled: January 29, 2013Date of Patent: December 27, 2016Assignee: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Kuiling Ding, Xiaoming Wang, Zhaobin Han, Xubin Wang, Zheng Wang
-
Patent number: 9518151Abstract: The present invention belongs to the field of preparation of high performance polymers, and specifically relates to a low dielectric constant polymer containing dinaphthyl and hexafluorocyclobutyl ether units, and preparation method and use thereof. The polymer is prepared as follows: under the effect of an alkali, 1-naphthol bromotetrafluoroethane ether is prepared from 1-naphthol and tetrafluorodibromoethane in an organic solvent, and then reduced by a zinc powder so as to obtain 1-naphthol trifluorovinyl ether. 1-naphthol trifluorovinyl ether is treated at a high temperature to obtain a bisnaphthol hexafluorocyclobutyl ether monomer. The monomer is subjected to oxidative coupling in the presence of ferric trichloride so as to obtain a thermal polymer containing dinaphthyl and hexafluorocyclobutyl structural units with a good film-forming property, and in a nitrogen atmosphere, the temperature for 5% weight loss (Td5%) of the obtained film is 437° C., and the carbon residue yield at 1000° C. is 54.24%.Type: GrantFiled: November 20, 2013Date of Patent: December 13, 2016Assignee: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Qiang Fang, Chao Yuan, Kaikai Jin, Yingchun Liu, Shen Diao, Kai Li
-
Patent number: 9518014Abstract: A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of ?-arylamino ?-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of ?-arylamino ?-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.Type: GrantFiled: January 29, 2013Date of Patent: December 13, 2016Assignee: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Kuiling Ding, Xiaoming Wang, Zheng Wang
-
Patent number: 9434665Abstract: Provided is a method for preparing methanol and diol from cyclic carbonate, comprising: under a hydrogen atmosphere, in an organic solvent, and with the presence of a ruthenium complex (Ru(L)XYY?) and an alkali, conducting a hydrogenation reduction reaction on the cyclic carbonate or polycarbonate to obtain methanol and diol. Also provided is a ruthenium complex prepared from ruthenium and a tridentate amido diphosphine ligand. Also provided is a deuterated methanol and deuterated diol preparation method by substituting the hydrogen and ruthenium complex with deuterium.Type: GrantFiled: March 22, 2013Date of Patent: September 6, 2016Assignee: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Kuiling Ding, Zhaobin Han
-
Publication number: 20160215363Abstract: Provided is a backflow cascade novel process for producing a lithium-7 isotope. The process comprises an upper backflow section, an extraction section, an enrichment section, a lower backflow section, and a product acquiring section. Upper backflow phase-conversion liquid and lower backflow phase-conversion liquid are respectively added to the upper backflow section and the lower backflow section, and upper backflow phase-conversion liquid and lower backflow phase-conversion liquid of the lithium material are controlled; the product is precisely acquired in the product acquiring section; an organic phase is added to the upper backflow section, and is recycled in the lower backflow section. By means of cascade connection with a high-performance liquid separator, environmental protection, high efficiency, and multi-level enrichment of the lithium-7 isotope are achieved, and a high-abundance lithium-7 isotope product is obtained.Type: ApplicationFiled: March 28, 2014Publication date: July 28, 2016Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Jinbo Hu, Wei Zhang, Weiqin Zheng, Guanghua Chen, Xiao Shi, Yongchang Xu, Honggui Lv, Chengye Yuan
-
Patent number: 9315755Abstract: The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.Type: GrantFiled: April 23, 2012Date of Patent: April 19, 2016Assignee: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Yong Tang, Wenjie Tao, Xiuli Sun, Junfang Li, Zheng Wang
-
Publication number: 20150299822Abstract: The present invention discloses an extracting agent for separating lithium isotopes and an organic extraction phase containing the extracting agent; the organic extraction phase easily enriches 7Li and achieves the separation of lithium isotopes. The present invention also discloses a high-efficiency method for separating lithium isotopes in an aqueous solution, in which the organic extraction phase of the present invention is used, said organic extraction phase being suitable for single-stage and multi-stage extraction processes.Type: ApplicationFiled: May 8, 2013Publication date: October 22, 2015Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Beili Li, Huaiyu Sheng, Jinbo Hu
-
Publication number: 20150252055Abstract: Disclosed are aromatic spiroketal diphosphine ligands, preparation methods and uses thereof. The ligands have the structure of formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are defined as such described in the specification. The aromatic spiroketal diphosphine ligands are prepared from aromatic spiroketal compounds. Also disclosed are the preparation methods of aromatic spiroketal compounds. The preparation methods are simple and can produce racemic or chiral aromatic spiroketal diphosphine ligands. The ligands can be used as catalysts of asymmetrical catalytic reactions having economical practicability and industry application prospect.Type: ApplicationFiled: January 29, 2013Publication date: September 10, 2015Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Kuiling Ding, Xiaoming Wang, Zhaobin Han, Xubin Wang, Zheng Wang
-
Patent number: 9040738Abstract: Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds.Type: GrantFiled: December 17, 2010Date of Patent: May 26, 2015Assignees: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES, LIANHE CHEMICAL TECHNOLOGY CO., LTD, LIANHE CHEMICAL TECHNOLOGY (TAIZHOU) CO., LTDInventors: Dawei Ma, Shaolin Zhu, Shouyun Yu, You Wang, Qianghui Zhou
-
Patent number: 9012229Abstract: A capillary electrophoresis method for quantitatively analyzing characteristic oligosaccharide present in enoxaparin sodium is provided in this invention. The method may be used for quantitatively determining the contents of disaccharides, trisaccharides, tetrasaccharides and in particular oligosaccharides having a 1,6-anhydro ring, which are unique compounds for enoxaparin sodium, within an exhaustively digested enoxaparin sodium sample with a mixture of heparinase I, II, and III, so as to quantitatively determine the molar percentage of oligosaccharides having 1,6-anhydro ring in enoxaparin sodium. The method may be used for the pharmaceutical quality control of enoxaparin sodium during the manufacturing process.Type: GrantFiled: January 20, 2012Date of Patent: April 21, 2015Assignees: Hangzhou Jiuyuan Gene Engineering Co., Ltd., Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Jingwu Kang, Xueqiang Zhan
-
Publication number: 20150105567Abstract: The present invention relates to an optically active axially chiral ?-allenic alcohol, a synthetic method and use thereof. A method of preparing a high optically active chiral ?-allenic alcohol by using propargyl alcohol, aldehyde and chiral ?,?-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with a mediator zinc bromide. The axially chiral ?-allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high generality, the total yield is high, and enantioselectivity and diastereoselectivity are high.Type: ApplicationFiled: November 20, 2012Publication date: April 16, 2015Applicant: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCESInventors: Shenming Ma, Juntao Ye
-
Patent number: 8962329Abstract: Novel isolated DNA sequences which comprise all or part of a gene cluster encoding sanglifehrin synthase, processing and regulatory genes involved in the biosynthesis of a mixed non-ribosomal peptide/polyketide compound, or mutants having altered biosynthetic capability, polypeptides or mutants thereof encoded by DNA or the mutants, vectors containing the DNA or the mutants thereof, host cells transformed with the DNA, the mutants thereof, or the vector, and a method for producing sanglifehrin compounds. Compounds with cyclophilin inhibition activity used as immunosuppressants, antivirals or cardiac protection agents.Type: GrantFiled: September 24, 2009Date of Patent: February 24, 2015Assignee: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Wen Liu, Nan Jiang, Xudong Qu
-
Publication number: 20140221662Abstract: Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds.Type: ApplicationFiled: December 17, 2010Publication date: August 7, 2014Applicants: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES, LIANHE CHEMICAL TECHNOLOGY CO., LTD.Inventors: Dawei Ma, Shaolin Zhu, Shouyun Yu, You Wang, Qianghui Zhou
-
Patent number: 8748669Abstract: Provided is a process for producing aldehydes or ketones by oxidizing alcohols with oxygen, which comprises oxidizing alcohols to aldehydes or ketones in an organic solvent at room temperature with oxygen or air as an oxidant, wherein ferric nitrate (Fe(NO3)3.9H2O), 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) and an inorganic chloride are used as catalysts, the reaction time is 1-24 hours, and the molar ratio of said alcohols, 2,2,6,6-tetramethylpiperidine N-oxyl and the inorganic chloride is 100:1˜10:1˜10:1˜10. The present process has the advantages of high yield, mild reaction conditions, simple operation, convenient separation and purification, recoverable solvents, substrates used therefor being various and no pollution, and therefore it is adaptable to industrialization.Type: GrantFiled: July 30, 2010Date of Patent: June 10, 2014Assignees: East China Normal University, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Shengming Ma, Jinxian Liu, Jinqiang Kuang, Yu Liu, Yuli Wang, Qiong Yu, Weiming Yuan, Suhua Li, Bo Chen, Jiajia Cheng, Baoqiang Wan, Juntao Ye, Shichao Yu
-
Publication number: 20140088319Abstract: The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.Type: ApplicationFiled: April 23, 2012Publication date: March 27, 2014Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Yong Tang, Wenjie Tao, Xiuli Sun, Junfang Li, Zheng Wang
-
Publication number: 20140073500Abstract: Organic compounds containing heteroatoms and their use in preparing Ziegler-Natta(Ziegler-Natta) catalyst with single activation center. The Ziegler-Natta olefin polymerization catalyst is preparing by adding organic or inorganic solid carrier or compound of them which is pre-activated by heating or pre-treated chemically, organic compound containing heteroatoms and metallic compound into magnesium compound/tetrahydrofuran solution. The Ziegler-Natta olefin polymerization catalyst prepared in the present invention is fluidizable powder and can prepare ethene homopolymer and copolymer of controllable construction with high catalytic activity, during homo-polymerization and combined polymerization with alpha-olefin of C3˜C18 under action of catalyst promoter such as alkyl aluminum, alkyl aluminoxane, and so on.Type: ApplicationFiled: September 16, 2013Publication date: March 13, 2014Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Yong Tang, Xiaohong Yang, Bo Liu, Xiuli Sun, Zhi Ma, Yuan Gao, Cong Wang
-
Patent number: 8563739Abstract: The invention relates to a novel class of ruthenium complexes containing phosphine and hybrid amine ligands, their preparation and use as catalysts in the reduction of simple ketones to alcohols by molecular hydrogenation. The reactivity and enantioselectivity of such complexes in the asymmetric hydrogenation of simple ketones could be enhanced by the addition of some selective additives.Type: GrantFiled: June 12, 2009Date of Patent: October 22, 2013Assignees: Enantiotech Corporation Limited, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Christian A Sandoval, Yue-hui Li