Patents Assigned to Shimizu Pharmaceutical Co., Ltd.
  • Patent number: 6399110
    Abstract: A neutral glucose-containing preparation with excellent stability and a near physiological pH, as a transfusion preparation with minimal glucose degradation by-products and a greatly reduced formic acid content; specifically, a glucose-containing preparation comprising separately housed first and second solutions, the first and second solutions satisfying the following conditions: (a) the first solution contains 2-50% glucose, and its pH is adjusted to 3-5 with an organic acid buffer solution; (b) the second solution contains an alkalizing agent, and has a pH value of 8-13 as a pH adjustor for the first solution; and (c) the glucose concentration is 1-15% in the preparation solution obtained by mixing the first solution and second solution, and the pH of the solution is in a range of 6-8. It is used particularly as a peritoneal perfusate, such as a perfusate for Continuous Ambulatory Peritoneal Dialysis (CAPD).
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: June 4, 2002
    Assignee: Shimizu Pharmaceutical Co., Ltd.
    Inventors: Takumi Kikuchi, Kouichi Hirano
  • Patent number: 6232345
    Abstract: A cerebral function improving agent containing as the active ingredient a compound represented by the following formula: wherein R2 represents a hydrogen atom when R1 is a hydroxyl group; or R1 and R2 in combination represent an oxo group; R3 represents a hydrogen atom, an alkali metal, or a monohydric, dihydric or trihydric alcohol residue; which may be an oligomer composed of 2-10 molecules when R1 represents a hydroxyl group and R2 and R3 represent hydrogen atoms. The agent supresses cerebral edema, protects cerebral function, activates cerebral metabolisms and reduces the extent of cerebral infarction.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: May 15, 2001
    Assignee: Shimizu Pharmaceutical Co., Ltd.
    Inventors: Atsushi Hiraide, Sekiko Dohi, Motohisa Suzuki, Yoshihiro Shiba
  • Patent number: 6136862
    Abstract: A cerebral function improving agent containing as the active ingredient a compound represented by the following formula: ##STR1## wherein R.sub.2 represents a hydrogen atom when R.sub.1 is a hydroxyl group;or R.sub.1 or R.sub.1 are combined together to form an oxo group;R.sub.3 represents a hydrogen atom, an alkali metal, or a monohydric, dihydric or trihydric alcohol residue,which may be an oligomer composed of 2-10 molecules when R.sub.1 represents a hydroxyl group and R.sub.2 and R.sub.3 represent hydrogen atoms.The agent suppresses cerebral edema, protects cerebral function, impaired cerebral energy metabolism, and reduces the extent of cerebral infarction.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: October 24, 2000
    Assignee: Shimizu Pharmaceutical Co., Ltd.
    Inventors: Atsushi Hiraide, Sekiko Dohi, Motohisa Suzuki, Yoshihiro Shiba
  • Patent number: 4576930
    Abstract: A transfusion preparation for intravenous infusion which contains glucose, electrolytes, a chelating agent, e.g., citric acid, a salt of polyhydric alcohol or monosaccharide phosphoric ester, e.g., sodium glycerophosphate and has a pH adjusted to 5 to 7.5. This preparation is free from coloring or precipitation on autoclave sterilization and can be administered into the central and peripheral veins without affecting venous tissue.
    Type: Grant
    Filed: July 7, 1983
    Date of Patent: March 18, 1986
    Assignee: Shimizu Pharmaceutical Co., Ltd.
    Inventors: Tohru Sugiyama, Yasuo Suzuki, Katsumasa Katagiri, Satoshi Furutani