Patents Assigned to Sidney Farber Cancer Institute, Inc.
  • Monoclonal antibody
    Patent number: 4443427
    Abstract: Monoclonal antibodies specific to a mature human T cell surface antigen of molecular weight of about 120,000 daltons as determined by electrophoresis, the antigen not being modulated by monoclonal antibodies specific to it and being restricted within the human lymphoid system to the surface of mature T cells, the monoclonal antibodies being capable of selectively binding mature human T cells and rendering them inactive in vivo and failing to induce the proliferation or activation of human lymphocytes.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: April 17, 1984
    Assignee: Sidney Farber Cancer Institute, Inc.
    Inventors: Ellis L. Reinherz, Stuart F. Schlossman
  • Apparatus and method for killing unwanted cells
    Patent number: 4395397
    Abstract: Method and apparatus for removing, from a flowing liquid stream containing a suspension of living cells, a subpopulation of unwanted cells having one or more characteristics distinguishing them from the rest of the living cells. The method includes detecting the presence of the unwanted cells, generating signals in response to the presence of the unwanted cells, and providing pulses of laser light, in response to the generated signals, to impinge on and kill the unwanted cells.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: July 26, 1983
    Assignee: Sidney Farber Cancer Institute, Inc.
    Inventor: Howard M. Shapiro
  • N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same
    Patent number: 4299822
    Abstract: N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate having antitumor activity and low toxicity are soluble in water at a physiological pH ranging from 7.2 to 7.5.
    Type: Grant
    Filed: June 9, 1980
    Date of Patent: November 10, 1981
    Assignee: Sidney Farber Cancer Institute, Inc.
    Inventors: Mervyn Israel, Gopalakrishnan Potti
  • N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
    Patent number: 4035566
    Abstract: Esters of C.sub.4 -C.sub.10 saturated fatty acids with N-trifluoroacetyladriamycin are novel compounds. These compounds have the following structure: ##STR1## in which A is alkanoate having from 4 to 10 carbon atoms. Therapeutic compositions containing these compounds or the acetate or propionate of N-trifluoroacetyladriamycin are more effective than adriamycin in antitumor activity against murine P 388 and L 1210 leukemias and Ridgway osteogenic sarcoma in mice and at the same time significantly less toxic than adriamycin.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: July 12, 1977
    Assignee: Sidney Farber Cancer Institute, Inc.
    Inventors: Mervyn Israel, Edward J. Modest