Abstract: The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function.

Abstract: The present invention relates to an automated analysis device (1) and a method for temporary, energy-saving operation of the analysis device (1) in a standby mode, the analysis device (1) comprising a central control unit (6) and a standby control unit (24).

Abstract: The invention is in the field of in vitro diagnostics and relates to a method for ascertaining a transmission value for a light signal that is pulsed at a frequency through a specimen in an automatic analysis appliance. It also relates to a transmission measurement apparatus for an automatic analysis appliance, comprising a light source that is pulsed at a frequency and a photodetector having a downstream A/D converter.

Abstract: The invention relates to a reagent station (1) for an automated analysis device, comprising a first and a second reagent container storage (2, 10) and a transfer apparatus (20) which transfers reagent containers (16) between the first and the second reagent container storage (2, 10). Furthermore, the invention relates to a method for loading an automated analysis device with reagent containers.

Abstract: The disclosure relates, in some embodiments, to sequences of a novel mutant or variant of the hepatitis B surface antigen (HBsAg) and methods for detecting this genome and protein variant, and antibodies directed against it, from patients' samples.

Abstract: A closure device including a first and second closure element, the first closure element, which has an opening, being mounted on the opening of a container to be closed and the second closure element being movably connectable to the first closure element, the first closure element of the device having on the bottom surface facing the container a raised edge, which encircles the opening and has a sharp-edged region and a blunt region.

Abstract: A device for the photometric examination of samples has a sample-holder apparatus for at least two sample vessels, and a measuring apparatus and a moveable apparatus. The sample-holder apparatus is designed to be stationary, and the measuring apparatus is arranged on the moveable apparatus such that it can be displaced by means of the moveable apparatus.

Abstract: The invention is in the field of coagulation diagnostics and relates to a heparin-insensitive method for determining direct coagulation factor inhibitors in a sample, in particular direct thrombin and factor Xa inhibitors.

Abstract: The invention relates to a hollow needle (1) for a sample pipettor in an automated analysis instrument, which sample pipettor is suitable for withdrawing sample liquid from a sealed sample vessel by virtue of the cover or the cap of the sample vessel being pierced by the hollow needle (1). The hollow needle (1) has a substantially straight cylindrical basic shape with a tip (8) for piercing a cover and enables a removal of sample liquid, comparatively less susceptible to errors, from a sample vessel in an automated analysis instrument. In the region of the tip (8) of the hollow needle (1), a number of faces (22, 26, 28, 30) have been introduced in such a way that the radial force components resulting at the respective faces (22, 26, 28, 30) during an axial movement into an elastic material cancel one another.

Abstract: The present invention relates to a routine in vitro method for determining platelet-associated analytes, for example VWF, factor XIII, fibrinogen or D-dimer, in a sample of platelet-rich plasma.

Abstract: The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment of cardiovascular diseases. Furthermore, the invention relates to the creation of an individual risk profile of negative events that are associated with the progression of arteriosclerosis.

Abstract: The invention relates to an adjustment system (3) for a transfer system (1) in an in-vitro diagnostics system. The adjustment system comprises a contact element (4), which is arranged on a movable element (2) of the transfer system (1). The contact element (4) is arranged on the movable element (2) by means of a joint element (5), wherein the joint element (5) has a self-resetting design and wherein a distance measuring sensor (7, 8) is associated with a distance between the contact element (4) and the movable element (2). The adjustment system enables a quick automated adjustment.

Abstract: A reaction vessel (1) with an enclosing wall (4) and an opening (6) for holding liquids to be analyzed enables particularly flexible automatic processing and, at the same time, high quality measurement results. To this end, the enclosing wall (4) comprises a first section (10), in which at least the external surface has a substantially circularly symmetric design, and a second section (12), which has at least two planar areas (14), which comprise a light-transmissive material, are opposite to one another and arranged in parallel, and wherein the reaction vessel (1) has a means (12, 22, 26) for orienting the reaction vessel (1) in a receiving position.

Abstract: The invention relates to a kit for a homogenous detection method for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogenous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.

Abstract: The invention relates to sequences of a novel variant of the Hepatitis B surface antigen (HBsAg) and to methods for detecting, in patient samples, nucleic acids, antigens, and antibodies directed against the same.

Abstract: The present invention is in the area of coagulation analysis and relates to a reagent which is based on recombinant or native tissue factor and phospholipids and which can be stabilized by adding a polyphenol.

Abstract: The present invention is in the field of coagulation diagnostics and relates to a screening process for finding samples containing antiphospholipid antibodies (lupus anticoagulants), wherein the platelet aggregation-stimulating action of said antiphospholipid antibodies is determined in vitro.

Abstract: The present invention is in the field of in vitro diagnostics and relates to a method for recognizing interfering disruptive factors, such as heterophile antibodies or rheumatoid factors for example, in a sample.

Abstract: A method for quantitatively analyzing an anticoagulant in a sample may include: (a) providing and incubating a reaction mixture comprising (i) the sample, (ii) a defined amount of an activated coagulation factor whose activity is directly or indirectly influenceable by the anticoagulant to be determined, wherein the activated coagulation factor is present in a separate reagent which is added to the reaction mixture, (iii) a cleavable substrate which has at least one cleavage site for the activated coagulation factor, and (iv) a solid phase to which the cleavable substrate is bound or becomes bound during the incubation; (b) separating the solid phase; and (c) determining the amount of solid-phase-bound, uncleaved substrate, wherein the determined amount of the solid-phase-bound uncleaved substrate is proportional to an amount or activity of the anticoagulant in the sample.

Abstract: The invention relates to a pipetting device for automatic analysis instruments and a method for heating a volume of liquid in a heated pipetting needle.