Abstract: 8-Hydroxy quinoline derivative compounds for enhancing telomerase reverse transcriptase (TERT) expression, and methods for using the same, are provided. These compounds and methods find use in a variety of applications in which increased expression of telomerase reverse transcriptase is desired.
Type:
Grant
Filed:
May 18, 2011
Date of Patent:
July 18, 2023
Assignee:
Sierra Sciences, Inc.
Inventors:
William H. Andrews, Lancer K. Brown, Laura A. Briggs, Federico C. A. Gaeta, Hamid Mohammadpour, Mieczyslaw A. Piatyszek
Abstract: Telomerase repressor proteins and nucleic acid compositions encoding the same are provided. The subject repressor proteins bind to a repressor site in the TERT minimal promoter, e.g., a Site C site, and thereby inhibit TERT expression. Also provided are methods of modulating, e.g., inhibiting or enhancing, TERT expression. The subject invention finds use in a variety of different applications, including therapeutic and therapeutic agent screening applications.
Type:
Grant
Filed:
March 20, 2007
Date of Patent:
September 14, 2010
Assignee:
Sierra Sciences Inc.
Inventors:
William H. Andrews, Christopher A. Foster, Stephanie Fraser, Hamid Mohammadpour, Laura Briggs
Abstract: Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the GC-Box 5 repressor site with a repressor protein (or protein complex including the same) is modulated to achieve the desired change in TERT expression. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like.
Type:
Grant
Filed:
April 16, 2004
Date of Patent:
October 9, 2007
Assignee:
Sierra Sciences, Inc.
Inventors:
William H. Andrews, Christopher A. Foster, Stephanie Fraser, Hamid Mohammadpour, Laura Briggs
Abstract: Methods and compositions for assaying an agent for TERT promoter modulatory activity are provided. In the subject methods, an agent is contacted with a cell comprising a mutant telomerase structural RNA component (TR) that results in a detectable phenotype in the presence of telomerase reverse transcriptase (TERT). Also provided are compositions, systems and kits thereof, as well as devices, that find use in practicing the subject methods. The subject invention finds use in assaying agents for TERT promoter modulatory activity, such as in a high throughput format.
Type:
Grant
Filed:
March 21, 2005
Date of Patent:
June 5, 2007
Assignee:
Sierra Sciences, Inc.
Inventors:
William H. Andrews, Laura Briggs, Lancer K. Brown, Christopher A. Foster, Mieczyslaw A. Piatyszek
Abstract: Telomerase repressor proteins and nucleic acid compositions encoding the same are provided. The subject repressor proteins bind to a repressor site in the TERT minimal promoter, e.g., a Site C site, and thereby inhibit TERT expression. Also provided are methods of modulating, e.g., inhibiting or enhancing, TERT expression. The subject invention finds use in a variety of different applications, including therapeutic and therapeutic agent screening applications.
Type:
Grant
Filed:
June 21, 2002
Date of Patent:
May 1, 2007
Assignee:
Sierra Sciences, Inc.
Inventors:
William H. Andrews, Christopher A. Foster, Stephanie Fraser, Hamid Mohammadpour, Laura Briggs
Abstract: Methods and compositions are provided for modulating, and generally upregulating, the expression of telomerase reverse transcriptase (TERT) by blocking repression of TERT transcription, e.g., by inhibiting binding of repressor factor to a Site C repressor binding site located in the TERT minimal promoter. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like. In further describing the subject invention, the methods and compositions of the invention are described first in greater detail, followed by a review of the various applications in which the subject invention finds use.
Type:
Grant
Filed:
August 17, 2001
Date of Patent:
February 3, 2004
Assignee:
Sierra Sciences, Inc.
Inventors:
William H. Andrews, Christopher A. Foster, Stephanie Fraser, Hamid Mohammadpour