Patents Assigned to Sigma-Aldvich Co. LLC
  • Genome editing of a locus using zinc-finger nucleases
    Patent number: 8771985
    Abstract: Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: July 8, 2014
    Assignees: Sangamo BioSciences, Inc., Sigma-Aldvich Co. LLC
    Inventors: Xiaoxia Cui, Gregory Davis, Philip D. Gregory, Michael C. Holmes, Edward J. Weinstein