Patents Assigned to Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
  • 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists
    Patent number: 7589099
    Abstract: Compounds of Formula (I) are described: in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: September 15, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Ming Hong, Sabrina Dallavalle, Lucio Merlini, Maria Ornella Tinti, Franco Zunino
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Patent number: RE40861
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: July 21, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria O. Tinti, Piero Chiodi, Arduino Arduini