Patents Assigned to Sigma-Tau Industrie Farmaceutiche
  • Patent number: 8536160
    Abstract: Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: September 17, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Giorgio Fedrizzi, Alessandra Benicchio, Giuseppe Bianchi, Patrizia Ferrari, Mauro Gobbini, Rosamaria Micheletti, Marco Pozzi, Piero Enrico Scotti
  • Patent number: 8530517
    Abstract: The present invention relates to new retinoid derivatives of formula I and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumors, metastatic cancer, diabetic retinopathy, psoriasis, chronic inflammatory diseases or atherosclerosis.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 10, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Walter Cabri, Giuseppe Giannini, Gianfranco Battistuzzi, Domenico Alloatti, Claudio Pisano, Sabrina Dallavalle, Tiziana Brunetti
  • Patent number: 8518961
    Abstract: The present invention relates to novel pharmaceutical compositions in which the active agent is a topoisomerase I inhibitor, in particular a camptothecin derivative, that is useful for the treatment and prevention of proliferative diseases including cancer.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: August 27, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Isabel Ottinger
  • Patent number: 8518455
    Abstract: A method for treating myocardial or skeletal muscle anoxia which occurs in coronary or post-infarct disorders or during prolonged physical activity and muscle fatigue. This method comprises the administration of a combination composition comprising (a) an alkanoyl L-carnitine selected from the group consisting of isovaleryl L-carnitine, propionyl L-carnitine or the pharmacologically acceptable salts thereof or mixtures thereof; and (b) ribose or a phosphate derivative thereof.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: August 27, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Pola Pietro
  • Publication number: 20130203848
    Abstract: The invention, described herein, is directed to the use of acetyl. L-carnitine, or propionyl L-carnitine, or a salt thereof, for preparing a medicament for increasing neurogenesis in neural tissue; in winch said increased neurogenesis is useful for preventing central nervous system disorders due to ageing or genetic predisposition.
    Type: Application
    Filed: June 10, 2011
    Publication date: August 8, 2013
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Mariagrazia Grilli, Pier Luigi Canonico, Aleardo Koverech
  • Publication number: 20130137651
    Abstract: The present invention relates to a solid powder composed of a mixture of a natural or a synthetic polymer which forms a gel, a buffer, such as an hydroxyacid or a dicarboxyacid, a saccharide, one or more drugs useful for the treatment of diseases of the eyes and optionally one or more excipients and/or regulators of the osmotic pressure ophthalmologically acceptable.
    Type: Application
    Filed: January 25, 2013
    Publication date: May 30, 2013
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventor: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
  • Patent number: 8431617
    Abstract: The use of resveratrol is described fir the preparation of a medicament for the treatment of influenza. Said medicament exerts itself in therapeutic activity through inhibition of viral replication.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: April 30, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Enrico Garaci, Anna Teresa Palamara
  • Patent number: 8415392
    Abstract: L-carnitine, acetyl L-carnitine and propionyl L-carnitine inner salts, or their pharmaceutically acceptable salts, are used in combination to treat oligoasthenoteratosperia including oligospermia, asthenospermia, and teratospermia.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: April 9, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite, S.p.A.
    Inventors: Giorgio Cavallini, Giulio Biagiotti, Aleardo Koverech, Francesca Sardelli
  • Patent number: 8394854
    Abstract: The use of L-carnitine, or one of its pharmaceutically acceptable salts, is described in combination with glucose for the preparation of a medicament useful for diminishing the number of deaths caused by acute myocardial infarction, for reducing the number of days infarction patients spend in intensive care in hospital, and for reducing the number of episodes of post-infarction heart failure, in which the L-carnitine is administered intravenously within only a few hours of the onset of symptoms of acute myocardial infarction at an initial dose of 9 grams a day in combination with 1000-1500 mL of a 5% glucose solution for 5 days, after which the L-carnitine treatment is continued at a dose of 4 grams a day administered orally.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: March 12, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Aleardo Koverech
  • Patent number: 8389574
    Abstract: The present invention relates to the use of acetyl L-carnitine in combination with an anti hypertensive drug, and a statin, for the preparation of a medicament for the prevention or delay of onset of type 2 diabetes and its complications, in pre-diabetic patients with insulin resistance.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: March 5, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Claudio Cavazza, Paolo Carminati
  • Patent number: 8389014
    Abstract: The present invention relates to a solid powder composed of a mixture of a natural or a synthetic polymer which forms a gel, a buffer, such as an hydroxyacid or a dicarboxyacid, a saccharide, one or more drugs useful for the treatment of diseases of the eyes and optionally one or more excipients and/or regulators of the osmotic pressure ophthalmologically acceptable.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: March 5, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Antonio Longo, Mose Santaniello, Nicola Pescosolido, Aleardo Koverech
  • Patent number: 8383616
    Abstract: The present invention relates to formula I compounds having antitumoural activities through, as one possible biological target, the molecular chaperone heat shock protein 90 (Hsp90) inhibition. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of Hsp90 is responsive, and the pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 26, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Giuseppe Giannini, Walter Cabri, Daniele Simoni, Riccardo Baruchello, Claudio Pisano, Gabriella Singrossi, Silvia Carminati, Giuseppe Paolo Carminati
  • Publication number: 20130045940
    Abstract: It is described a composition in the form of eye drops or ointment, comprising as active ingredients L-carnitine or a physiologically acceptable salt thereof; and 3-Hydroxykynurenine O-?-DL-glucoside, useful for preventing or treating pathologies of the eyes due to ultraviolet radiation.
    Type: Application
    Filed: February 10, 2011
    Publication date: February 21, 2013
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Nicola Pescosolido, Aleardo Koverech
  • Patent number: 8377988
    Abstract: Use of L-carnitine and/or of one or more alkanoyl L-carnitines or one of their pharmaceutically acceptable salts for the preparation of an ophthalmic physiological supplement or medicament in the form of eye-drops, for the treatment of corneal diseases.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: February 19, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Aleardo Koverech, Nicola Pescosolido
  • Patent number: 8349317
    Abstract: Use of L-carnitine and/or one or more alkanoyl L-carnitines or one of their pharmaceutically acceptable salts for the preparation of a dietary supplement or medicament for the treatment of corneal diseases is disclosed.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: January 8, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Franco Gaetani, Janos Feher
  • Publication number: 20130005670
    Abstract: It is described a combination composition comprising as active ingredients L-carnitine or propionyl L-carnitine, troxerutine, diosmine and hesperidine, useful for the prevention and/or treatment of chronic venous diseases.
    Type: Application
    Filed: February 7, 2011
    Publication date: January 3, 2013
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Mohamed Ashraf Virmani, Aleardo Koverech
  • Patent number: 8343979
    Abstract: Erectile dysfunction is treated with a combination of propionyl L-carnitine in combination with sildenafil, apomorphine prostaglandin El, pentolamine and papaverine.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: January 1, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Aleardo Koverech, Andrea Lenzi
  • Patent number: 8337828
    Abstract: It is described the use of thymosin alpha 1 in combination with long pentraxin PTX3 or Ganciclovir, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: December 25, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Luigina Romani, Francesco Bistoni, Enrico Garaci
  • Patent number: 8318911
    Abstract: An anti-EpCAM antibody, designated ST3232/10, of marine origin exhibits properties suitable for both therapeutic and diagnostic applications. It shows high affinity for the native antigen and good tumor selectivity.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: November 27, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Anna Maria Anastasi, Fiorella Petronzelli, Rita De Santis, Saverio Alberti
  • Patent number: 8292869
    Abstract: A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: October 23, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Giovanni Paganelli, Marco Chinol