Patents Assigned to Singapore Volition Pte Limited
  • Detection of histone modification in cell-free nucleosomes
    Patent number: 10408831
    Abstract: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: September 10, 2019
    Assignee: SINGAPORE VOLITION PTE. LIMITED
    Inventors: Lindsay Jane Bawden, Elisabeth Ann Bone, Alan Hastings Drummond, Lindsey Ann Needham
  • METHOD FOR DETECTING NUCLEOSOME ADDUCTS
    Publication number: 20170276684
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Applicant: Singapore Volition Pte Limited
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG
  • Method for detecting nucleosome adducts
    Patent number: 9709569
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: July 18, 2017
    Assignee: SINGAPORE VOLITION PTE. LIMITED
    Inventors: Jacob Vincent Micallef, Mark Edward Eccleston, Marielle Herzog
  • METHOD FOR DETECTING HISTONE MODIFICATIONS IN NUCLEOSOMES
    Publication number: 20170003296
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone modifications and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone modification biomarkers for the detection and diagnosis of disease and to said histone modification biomarkers identified by said method.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 5, 2017
    Applicant: SINGAPORE VOLITION PTE LIMITED
    Inventor: Mark Edward ECCLESTON
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE VARIANTS
    Publication number: 20160299152
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: June 22, 2016
    Publication date: October 13, 2016
    Applicant: SINGAPORE VOLITION PTE. LIMITED
    Inventor: Jacob Vincent MICALLEF
  • Method for detecting nucleosomes containing histone variants
    Patent number: 9400276
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: July 26, 2016
    Assignee: SINGAPORE VOLITION PTE. LIMITED
    Inventor: Jacob Vincent Micallef
  • METHOD FOR DETECTING NUCLEOSOME ADDUCTS
    Publication number: 20160097772
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: October 5, 2015
    Publication date: April 7, 2016
    Applicant: SINGAPORE VOLITION PTE LIMITED
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG
  • METHOD FOR PREDICTING THERAPY EFFICACY USING NUCLEOSOME STRUCTURE BIOMARKERS
    Publication number: 20160003848
    Abstract: The invention relates to a method for predicting the efficacy of therapeutic treatments, particularly neoadjuvant cancer treatments, using the levels of cell free nucleosome structures.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 7, 2016
    Applicant: Singapore Volition Pte Limited
    Inventor: Stefan HOLDENRIEDER
  • Method for detecting nucleosomes
    Patent number: 9222937
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and the use of such measurements for the detection and diagnosis of disease.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: December 29, 2015
    Assignee: Singapore Volition Pte. Limited
    Inventor: Jacob Vincent Micallef
  • Method for detecting nucleosome adducts
    Patent number: 9187780
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: November 17, 2015
    Assignee: Singapore Volition Pte. Limited
    Inventors: Jacob Vincent Micallef, Mark Edward Eccleston, Marielle Herzog
  • Detection of histone modification in cell-free nucleosomes
    Patent number: 9128086
    Abstract: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: September 8, 2015
    Assignee: SINGAPORE VOLITION PTE. LIMITED
    Inventors: Lindsay Jane Bawden, Elizabeth Ann Bone, Alan Hastings Drummond, Lindsey Ann Needham
  • METHOD FOR DETECTING NUCLEOSOMES
    Publication number: 20140206015
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and the use of such measurements for the detection and diagnosis of disease.
    Type: Application
    Filed: August 31, 2012
    Publication date: July 24, 2014
    Applicant: Singapore Volition Pte Limited
    Inventor: Jacob Vincent Micallef