Patents Assigned to SISA Incorporated
  • 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7.alpha.-methyl-morphinan-6-one and therapeutic method of treating pain with it
    Patent number: 4370333
    Abstract: Disclosed is the novel analgesic/narcotic antagonist 17-cyclopropylmethyl-3-hydroxy-14-methoxy-7.alpha.-methyl-morphinan-6-one.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: January 25, 1983
    Assignee: SISA, Incorporated
    Inventors: Anil C. Ghosh, Raj K. Razdan
  • 4,5.alpha.-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
    Patent number: 4347361
    Abstract: Disclosed are 4,5.alpha.-epoxy-3-hydroxy or methoxy-7-(1-hydroxyalkyl or 1-oxoalkyl)morphinan-6-one compounds characterized by the structural formulae: ##STR1## In the foregoing formulae R is methyl, cyclopropylmethyl, cyclobutylmethyl, propargyl, allyl, dimethylallyl, cis-chloroallyl or furfuryl; R.sub.1 is H or methyl; R.sub.2 is straight or branched chain alkyl of from 1 to 10 carbon atoms, aryl, substituted aryl or arylalkyl, in which the alkyl group contains from 1 to 6 carbon atoms, and R.sub.3 is a straight chain alkyl of 1 to 4 carbon atoms.
    Type: Grant
    Filed: December 10, 1980
    Date of Patent: August 31, 1982
    Assignee: SISA, Incorporated
    Inventors: James E. Quick, Raj K. Razdan, Haldean C. Dalzell
  • 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
    Patent number: 4272540
    Abstract: Disclosed are 14-methoxy substituted 3-hydroxy or 3-methoxy -6-one morphinans characterized by the structural formula: ##STR1## wherein R is H or methyl; R.sub.1 is H, .alpha. methyl or .beta. methyl; and R.sub.2 is cyclobutylmethyl, cyclopropylmethyl, tetrahydrofurfuryl or dimethylallyl. The compounds of the present invention are variously useful as analgesics, narcotic antagonists and mixed analgesics/narcotic antagonists.
    Type: Grant
    Filed: April 24, 1979
    Date of Patent: June 9, 1981
    Assignee: SISA, Incorporated
    Inventors: Raj K. Razdan, Anil C. Ghosh
  • 17-Cyclopropylmethyl-14-hydroxy-3-methoxymorphinan-6-one and method of treating pain with it
    Patent number: 4260617
    Abstract: Disclosed is 17-cyclopropylmethyl-14-hydroxy-3-methoxymorphinan-6-one. This compound is a mixed agonist (analgesic)/narcotic antagonist and therefore useful for the treatment of moderate to severe pain without the liability of inducing physical dependence.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: April 7, 1981
    Assignee: SISA, Incorporated
    Inventors: Raj K. Razdan, Anil C. Ghosh
  • 17-Cyclobutylmethyl-4,5.alpha.-e poxy-3-hydroxy-14-methoxy-8.alpha.-methylmorphinan-6-one, and method of treating pain with it
    Patent number: 4232028
    Abstract: Disclosed is 17-cyclobutylmethyl-4,5.alpha.-epoxy-3-hydroxy-14-methoxy-8.alpha.-methylm orphinan-6-one characterized by the formula: ##STR1## This compound is useful as a mixed analgesic/narcotic antagonist.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: November 4, 1980
    Assignee: Sisa, Incorporated
    Inventors: Raj K. Razdan, Anil C. Ghosh
  • Composition and method for treating glaucoma
    Patent number: 4126694
    Abstract: Tetrahydrodibenzopyrans having the structure ##STR1## in which R, R.sub.1, and R.sub.2 are alkyl having from 1 to 4 carbon atoms and ophthalmologically acceptable acid addition salts thereof are effective anti-glaucoma agents, free from all but a very small amount of CNS activity, when applied topically.
    Type: Grant
    Filed: January 27, 1977
    Date of Patent: November 21, 1978
    Assignee: SISA Incorporated
    Inventors: Raj K. Razdan, Haldean C. Dalzell, Harry G. Pars
  • Anti-glaucoma composition and method
    Patent number: 4126695
    Abstract: Tetrahydrodibenzopyrans having the structure ##STR1## in which R.sub.1 is hydrogen or acetyl and R.sub.2 is alkyl having from 1 to 4 carbon atoms are effective anti-glaucoma agents, free from all but a very small amount of CNS activity, when applied topically.
    Type: Grant
    Filed: January 27, 1977
    Date of Patent: November 21, 1978
    Assignee: SISA Incorporated
    Inventors: Raj K. Razdan, Haldean C. Dalzell, Barbara Z. Terris, Harry G. Pars