Patents Assigned to Skeletal Kinetics LLC
-
Patent number: 10022471Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 ?m and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.Type: GrantFiled: March 13, 2013Date of Patent: July 17, 2018Assignee: Skeletal Kinetics, LLCInventors: Brent R. Constantz, David Delaney, Duran N. Yetkinler
-
Patent number: 9889223Abstract: Temperature-insensitive calcium phosphate cements and methods of using the same are provided. Aspects of the cements include a dry component having fine and coarse calcium phosphate particulate reactants and a setting fluid which includes a cellulose. The dry component and setting fluid may be combined over a broad temperature range to produce a flowable composition. The resultant flowable composition finds use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.Type: GrantFiled: March 29, 2016Date of Patent: February 13, 2018Assignee: Skeletal Kinetics, LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 9833274Abstract: Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.Type: GrantFiled: March 29, 2012Date of Patent: December 5, 2017Assignee: Skeletal Kinetics, LLCInventors: Duran Yetkinler, David Delaney, Brent R. Constantz
-
Patent number: 9827346Abstract: Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.Type: GrantFiled: August 4, 2015Date of Patent: November 28, 2017Assignee: Skeletal Kinetics, LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 9707024Abstract: Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.Type: GrantFiled: January 10, 2012Date of Patent: July 18, 2017Assignee: Skeletal Kinetics, LLCInventors: Duran N. Yetkinler, David Delaney, Brent R. Constantz
-
Patent number: 9295695Abstract: Temperature-insensitive calcium phosphate cements and methods of using the same are provided. Aspects of the cements include a dry component having fine and coarse calcium phosphate particulate reactants and a setting fluid which includes a cellulose. The dry component and setting fluid may be combined over a broad temperature range to produce a flowable composition. The resultant flowable composition finds use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.Type: GrantFiled: April 30, 2010Date of Patent: March 29, 2016Assignee: Skeletal Kinetics, LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 9101665Abstract: Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.Type: GrantFiled: January 24, 2014Date of Patent: August 11, 2015Assignee: Skeletal Kinetics, LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 8771748Abstract: Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.Type: GrantFiled: May 19, 2005Date of Patent: July 8, 2014Assignee: Skeletal Kinetics, LLCInventors: Brent R. Constantz, David Delaney, Duran Yetkinler
-
Patent number: 8673364Abstract: Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.Type: GrantFiled: September 28, 2009Date of Patent: March 18, 2014Assignee: Skeletal Kinetics, LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 8496900Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.Type: GrantFiled: July 20, 2012Date of Patent: July 30, 2013Assignee: Skeletal Kinetics LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Publication number: 20130165540Abstract: Porous calcium phosphate granules and methods of making the same are provided. Embodiments of the methods include producing a solid spherical granule precursor that includes: (i) a calcium phosphate component; and (ii) a porogen component; and (b) removing the porogen component from the solid spherical granule precursor to produce a spherical porous calcium phosphate granule. Granules of the invention find use in a variety of different applications.Type: ApplicationFiled: December 21, 2012Publication date: June 27, 2013Applicant: SKELETAL KINETICS, LLCInventor: SKELETAL KINETICS, LLC
-
Patent number: 8419803Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 ?m and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.Type: GrantFiled: July 25, 2005Date of Patent: April 16, 2013Assignee: Skeletal Kinetics LLCInventors: Brent R. Constantz, David Delaney, Duran Yetkinler
-
Patent number: 8409538Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.Type: GrantFiled: December 4, 2008Date of Patent: April 2, 2013Assignee: Skeletal Kinetics LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 8246736Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.Type: GrantFiled: June 3, 2011Date of Patent: August 21, 2012Assignee: Skeletal Kinetics, LLCInventors: Sahil Jalota, David C. Delaney, Duran N. Yetkinler
-
Patent number: 8118812Abstract: Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.Type: GrantFiled: October 4, 2005Date of Patent: February 21, 2012Assignee: Skeletal Kinetics, LLCInventors: Duran Yetkinler, David Delaney, Brent R. Constantz
-
Patent number: 7820191Abstract: Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.Type: GrantFiled: April 2, 2004Date of Patent: October 26, 2010Assignee: Skeletal Kinetics, LLCInventor: Brent R. Constantz
-
Patent number: 7658940Abstract: Aspects of the invention include methods for producing flowable compositions, e.g. pastes, that set into calcium phosphate containing products, where the products include autologous bone. Aspects of the invention further include compositions produced by the methods, as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.Type: GrantFiled: March 30, 2007Date of Patent: February 9, 2010Assignee: Skeletal Kinetics, LLCInventor: Brent R. Constantz
-
Publication number: 20070299248Abstract: Methods and compositions are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e.g., RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.Type: ApplicationFiled: June 29, 2007Publication date: December 27, 2007Applicant: SKELETAL KINETICS, LLCInventors: Brent Constantz, David Delaney
-
Publication number: 20070299454Abstract: Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.Type: ApplicationFiled: June 29, 2007Publication date: December 27, 2007Applicant: SKELETAL KINETICS, LLCInventors: Duran YETKINLER, David DELANEY, Brent CONSTANTZ
-
Patent number: 7306786Abstract: Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with setting fluid and a water-soluble contrast agent, e.g., a water-soluble barium salt, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.Type: GrantFiled: July 28, 2003Date of Patent: December 11, 2007Assignee: Skeletal Kinetics, LLCInventors: David Delaney, Brent Constantz