Abstract: The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
Type:
Application
Filed:
August 6, 2007
Publication date:
March 27, 2008
Applicant:
SKY HIGH, LLC
Inventors:
John Goddard, Donald Picker, Samuil Umansky, Steven Price, Jac Wijkmans, Edward Boyd, Anthony Baxter
Abstract: The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
Type:
Application
Filed:
September 26, 2005
Publication date:
March 23, 2006
Applicant:
Sky High, LLC
Inventors:
Ian Bathurst, Matthew Foehr, J. Goddard, Samuil Umansky, John Bradley, Donald Picker
Abstract: The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
Type:
Grant
Filed:
October 8, 2002
Date of Patent:
September 27, 2005
Assignee:
Sky High, LLC
Inventors:
Ian C. Bathurst, Matthew W. Foehr, J. Graham Goddard, Samiul R. Umansky, John D. Bradley, Donald H. Picker
Abstract: The present invention provides methods for extracting anti-apoptotic compositions from various protein isolates and/or lipid mixtures with aqueous solutions not containing organic solvents. The compositions extracted by the methods can be used for a variety of purposes, including for therapeutic, nutritional and medicinal purposes.
Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
Type:
Grant
Filed:
October 23, 2001
Date of Patent:
December 2, 2003
Assignee:
Sky High, LLC
Inventors:
Ian Cyril Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
Abstract: The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
Type:
Application
Filed:
October 8, 2002
Publication date:
August 7, 2003
Applicant:
SKY HIGH, LLC.
Inventors:
J. Graham Goddard, Samiul R. Umansky, John D. Bradley, Ian C. Bathurst, Matthew W. Foehr, Donald H. Picker
Abstract: A method to inhibit inflammation in a mammal is disclosed. The method includes administering to the mammal a composition comprising a phospholipid, which can be lysophosphatidic acid. The administration of a phospholipid is believed to down regulate expression of adhesion molecules on the surface of vascular endothelial cells and circulating leukocytes of the mammal.
Abstract: The present invention provides therapeutic compositions containing lysophosphotidic acids, methods for making the compositions, and methods of using the compositions in the preservation and treatment of organs.
Type:
Grant
Filed:
February 28, 2000
Date of Patent:
December 17, 2002
Assignee:
Sky High, LLC
Inventors:
Ian C. Bathurst, Matthew W. Foehr, J. Graham Goddard, Samiul R. Umansky, John D. Bradley, Donald H. Picker
Abstract: The present invention provides methods for extracting anti-apoptotic compositions from various protein isolates and/or lipid mixtures with aqueous solutions not containing organic solvents. The compositions extracted by the methods can be used for a variety of purposes, including for therapeutic, nutritional and medicinal purposes.
Abstract: The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
Type:
Application
Filed:
October 23, 2001
Publication date:
August 15, 2002
Applicant:
Sky High, LLC.
Inventors:
Ian Cyril Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
Abstract: The present invention provides methods for extracting anti-apoptotic compositions from various protein isolates and/or lipid mixtures with aqueous solutions not containing organic solvents. The compositions extracted by the methods can be used for a variety of purposes, including for therapeutic, nutritional and medicinal purposes.
Abstract: A composition comprising a storage-stable organ preservation solution, comprising a linear polyethylene glycol having an average molecular weight of approximately 20,000 Daltons and being essentially free of decomposition products. This solution can be used for organ preservation as a perfusate in a process in which the perfusate is flowed through the circulatory system of the organ, and can also be used for transplantation or routine open heart cardioplegic applications. The composition can be contained in a system comprising a means for preventing light exposure, especially UV light, to the solution. In addition, the system is preferably impervious to gases, particularly oxygen.
Type:
Grant
Filed:
February 12, 1998
Date of Patent:
November 27, 2001
Assignee:
Sky High, LLC
Inventors:
Winston Wicomb, Geoffrey Collins, Ian Bathurst, Matthew Foehr