Abstract: The present invention provides a pharmaceutical granule composition comprising cimetidine and, as a granulating agent and taste-masking agent, an ester of a polyhydroxy compound, and where desired a palatable pharmaceutically acceptable emulsifier. Particular esters are glycerol esters. The granules of the present invention can be used in the preparation of chewable tablets which have good palatability and bioavailability.
Type:
Grant
Filed:
December 20, 1988
Date of Patent:
October 15, 1991
Assignee:
Smith Kline Dauelsberg GmbH
Inventors:
Eberhard F. Gottwald, Hermann P. Osterwald, Horst M. Machoczek, David Mayron
Abstract: A pharmaceutical composition suitable for oral adminstration comprising particulate cimetidine suspended in an aqueous phase containing a buffer which maintains the pH at greater than 7 and a suspending agent.
Type:
Grant
Filed:
June 2, 1987
Date of Patent:
August 29, 1989
Assignee:
Smith Kline Dauelsberg GmbH
Inventors:
Eberhard F. Gottwald, Horst M. Machoczek
Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
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