Patents Assigned to SmithKline Beecham Limited
  • Process
    Patent number: 8765065
    Abstract: The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: July 1, 2014
    Assignees: GlaxoSmithKline LLC, SmithKline Beecham Limited
    Inventors: Luigi Martini, Philip Smith, Chi Leung Li, Ronald Raby
  • Composition and use
    Patent number: 8236345
    Abstract: A pharmaceutical composition, comprising a thiazolidinedione, such as Compound (I), metformin hydrochloride and a pharmaceutically acceptable carrier, wherein the thiazolidinedione and metformin hydrochloride are each dispersed within its own pharmaceutically acceptable carrier in the pharmaceutical composition and the use of such a composition in medicine.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: August 7, 2012
    Assignee: SmithKline Beecham Limited
    Inventors: Karen Lewis, Nicola Jayne Lilliott, Donald Colin MacKenzie
  • Injection molding process for the preparation of an oral delivery device for the pharmaceutically active agent
    Patent number: 8123509
    Abstract: An injection molding process for the preparation of an oral delivery device comprising a core which contains a pharmaceutically active agent, having a coating with one or more openings leading to such a core. The invention also relates to devices produced by the process, and to injection molds suitable for performing the process.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: February 28, 2012
    Assignee: SmithKline Beecham Limited
    Inventors: Allan J. Clarke, Robert Glinecke, Ronald Raby, Chi Leung Li, Luigi Martini
  • Swallow tablet comprising paracetamol
    Patent number: 7993673
    Abstract: A dosage form such as a swallow tablet or a capsule formulation is described comprising paracetamol, low levels of sodium bicarbonate or potassium bicarbonate or mixtures thereof, and at least one pharmaceutically acceptable excipient.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: August 9, 2011
    Assignee: SmithKline Beecham Limited
    Inventor: Timothy James Grattan
  • PHARMACEUTICAL FORMULATION
    Publication number: 20110123608
    Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
    Type: Application
    Filed: November 23, 2010
    Publication date: May 26, 2011
    Applicant: SmithKline Beecham Limited
    Inventors: Stephen Mark McAllister, Ronald K. Raby, JR., Adrian Brown, Allan J. Clarke
  • Sustained release paracetamol containing compositions
    Patent number: 7943170
    Abstract: A pharmaceutical composition comprising an immediate release phase and a sustained release phase of paracetamol is described which has a unique in vitro dissolution profile resulting in advantageous pharmacokinetic properties.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: May 17, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Shing Yue Chan, Timothy James Grattan, Bounkhiene Sengmanee
  • Piperidine compounds for use as orexin receptor antagonist
    Patent number: 7943645
    Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: May 17, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, Riccardo Novelli, Roderick Alan Porter
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Patent number: 7928124
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 19, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Clive Leslie Branch, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Geoffrey Stemp
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Patent number: 7928125
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 19, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Clive Leslie Branch, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Geoffrey Stemp
  • Process
    Patent number: 7923027
    Abstract: The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: April 12, 2011
    Assignees: SmithKline Beecham Limited, GlaxoSmithKline LLC
    Inventors: Luigi Martini, Philip Smith, Chi Leung Li, Ronald Raby
  • N-aroyl cyclic amines
    Patent number: 7919507
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: April 5, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Clive Leslie Branch, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Patent number: 7897618
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 1, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Clive Leslie Branch, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Geoffrey Stemp
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Patent number: 7893090
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 22, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Clive Leslie Branch, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Geoffrey Stemp
  • Pharmaceutical formulation
    Patent number: 7883721
    Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: February 8, 2011
    Assignee: SmithKline Beecham Limited
    Inventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown, Allan J. Clarke, Wayne Matthews, Daniel N. Margetson
  • Pharmaceutical formulation
    Patent number: 7842308
    Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: November 30, 2010
    Assignee: SmithKline Beecham Limited
    Inventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown, Allan J. Clarke
  • Process for the purification of a salt of clavulanic acid
    Patent number: 7767823
    Abstract: A process in which a salt of clavulanic acid, typically an amine salt or an alkali metal salt is exposed to conditions, particularly a pH of less than 6.0, which reduces the quantity of contaminating impurities. The process may be a washing process, a recrystallisation process or a preparative process.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: August 3, 2010
    Assignee: SmithKline Beecham Limited
    Inventors: John McKnight, Guo Zhang
  • N-aroyl cyclic amines
    Patent number: 7741329
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: June 22, 2010
    Assignee: SmithKline Beecham Limited
    Inventors: Clive Leslie Branch, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • Pleuromutilin derivatives as antimicrobials
    Patent number: RE43390
    Abstract: The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: May 15, 2012
    Assignees: GlaxoSmithKline LLC, SmithKline Beecham Limited
    Inventors: Valerie Joan Berry, Steven Dabbs, Colin Henry Frydrych, Eric Hunt, Francis Dominic Sanderson, Gary Woodnutt