Abstract: This invention relates to a process of preparation of nucleotide polymers wherein a lysate of a bacterial culture is passed successively through three columns (ion exchange resin, hydrophobic resin and molecular sieve), whereby there is obtained a substantially pure polynucleotidephosphorylase solution.Polymerization of this agent leads to non toxic and non pyrogen products.This invention relates also to products thus obtained and to therapeutic compositions containing the same.
Type:
Grant
Filed:
November 1, 1988
Date of Patent:
May 22, 1990
Assignee:
Societe de Conseils de Recherches et d'Applicatios Scientifiques (S.C.R.A.S.)
Inventors:
Chabrier De Lassauniere, Acaye S. Colote