Abstract: A luminometer includes a chassis protected by a cover whose interior is accessible past a closure flap, a detector for measuring photons with a measuring window, a platform for supporting specimen plates, fixed or able to be displaced along a system of orthogonal axes X, Y and Z, along at least one of the axes of the plane X or Y, and an electronic module for amplification and digitizing of data and an electronic module for processing these data, with the measuring detector being movable and the luminometer having elements for displacement in translation of this detector along the Z axis.
Type:
Grant
Filed:
March 4, 1998
Date of Patent:
April 23, 2002
Assignee:
Societe Francaise de Recherches et d'Investissements
(SFRI)
Abstract: A method for the qualitative and quantitative detection of damages to DNA, characterised in that it includes the steps of binding the target DNA to a sensitised substrate, subjecting the DNA to the action of a test composition comprising at least one damage-generating product, subjecting the DNA to the action of a composition containing at least one cell extract active in repairing the DNA and containing markers, and detecting directly or indirectly the markers optionally incorporated into the DNA, if the repair has been effective, wherein a washing step is included between the steps and the binding and damaging steps can be reversed. The invention also provides a method for capturing the DNA directly from the cells with a lysis solution and a method for determining the repair modulation effect of some molecules. The method is suitable for detecting DNA damage and the repair inhibition modulating activity of one or more molecules.
Type:
Grant
Filed:
November 25, 1997
Date of Patent:
July 17, 2001
Assignee:
Societe Francaise de Recherches et d'Investissements
(SFRI)
Inventors:
Christian Provot, Bernard Salles, Gilbert Fournie, Patrick Calsou
Abstract: Device for enabling at least one analysis to be performed automatically on various samples is provided with at least one head having at least one first subunit for sampling and distributing liquids, a working surface-for holding samples to be analyzed, reagents and reaction supports or vessels, a mechanical system for moving the at least one head within a horizontal plane above the working surface, at least one washing bowl to wash the at least one first subunit, at least one reading system to measure results of an analysis, and elements for controlling, checking and coordinating various stages of analysis. The device is particularly suitable for performing immunological tests.
Type:
Grant
Filed:
July 23, 1992
Date of Patent:
August 22, 1995
Assignee:
Societe Francaise de Recherches et d'Investissements (SFRI)
Inventors:
Michel Coeurveille, Christiane Rafilipomanana, Yves Barach, Magali Millet