Abstract: The invention develops models of functional proteomics. Simulation scenarios of protein pathway vectors and protein-protein interactions are modeled from limited information in protein databases. The system focuses on three integrated subsystems, including (1) a system to model protein-protein interactions using an evolvable Global Proteomic Model (GPM) of functional proteomics to ascertain healthy pathway operations, (2) a system to identify haplotypes customized for specific pathology using dysfunctional protein pathway simulations of the function of combinations of single nucleotide polymorphisms (SNPs) so as to ascertain pathology mutation sources and (3) a pharmacoproteomic modeling system to develop, test and refine proposed drug solutions based on the molecular structure and topology of mutant protein(s) in order to manage individual pathologies. The system focuses on simulating the degenerative genetic disease categories of cancer, neurodegenerative diseases, immunodegenerative diseases and aging.

Abstract: A commercial search agent (CSA) is used to access data in a distributed communications system. An initial search request constitutes a buyer's first search query at sellers' commercial database network. Analytical agents and seller promotions are used to inform the CSA, while negotiation commences after the initial RFQ. CSA's may be informed by analytical agents.

Abstract: The hybrid artificial immune system consists of three main layers, including a solution application layer that interacts with the environment, a solution generation layer that solves combinatorial optimization problems and a modeling layer that analyzes problems and presents solution scenarios. The system solves evolutionary multi-objective optimization problems in network computing, robotics, artificial neural networks, protein network modeling, evolutionary systems and evolutionary hardware.

Abstract: The invention pertains to a 3D intelligent SoC. The self-regulating data flow mechanisms of the 3D SoC are elucidated, particularly parallelization of multiple asynchronous 3D IC nodes and reconfigurable components. These behavioral mechanisms are organized into a polymorphous computing architecture with plasticity functionality. Software agents are employed for reprogrammable 3D SoC network operability. Metaheuristic algorithms are applied to solving MOOPs in the 3D SoC for continuous reprogrammability for multiple application environments.

Abstract: A system and methods are presented for the generation of hybridized efficient genetic algorithms (EGAS) applied to bi-objective optimization problems. Applications are made to engineering systems involving collective behaviors, including network computing, robotics and evolvable hardware.

Abstract: The connection architecture of a network on a chip (NoC) is described in which (a) nodes in octahedron sections are connected in an arc Benes network, (b) a hierarchy of node clusters are connected using a globally asynchronous locally asynchronous (GALA) configuration, (c) a double wishbone 2D torus ring is applied to connection between network layers and (d) data is routed using buffer modulation.

Abstract: 3D FPGAs are elucidated with (a) interlayer information sharing, (b) intermittent and variable timing of layer configuration and (c) multilayer multi-functionality. 3D FPGAs are applied to reprogrammable SoCs.

Abstract: A 3D memory management system is described involving (a) memory hierarchy with adjustable synchronous DRAM, (b) 3D active memory with integrated logic circuitry, cache and router, (c) reconfigurable memory, (d) adaptive queue processing, (e) data compression processing and (f) multiple memory components in hierarchical configurations.

Abstract: A high performance 3D semiconductor is described with cubic dimensional multi-node reprogrammable components for multi-functionality and intelligent behaviors. The system is modeled with dynamic EDA techniques. Applications of the intelligent SoC are specified, particularly embedded, multifunctional, DSP and high-performance computing applications.

Abstract: The invention describes IP cores applied to 3D FPGAs, CPLDs and reprogrammable SoCs. IP cores are (a) used for continuously evolvable hardware using 3D logic circuits, (b) applied with optimization metaheuristic algorithms, (c) applied by matching combinatorial logic of netlists generated by Boolean algebra to combinatorial geometry of CPLD architecture by reaggregating IP core elements and (d) continuous recalibration of IP cores with evolvable hardware in indeterministic environments for co-evolutionary reprogrammability.

Abstract: Three dimensional integrated circuitry is described with applications to hybrid multiprocessor and reconfigurable computing. Methods of fabrication of multilayer ICs are shown using multilayer TSVs.

Abstract: A system is described for the organization and self-assembly of collectives of nanorobots (CNRs) and microrobots using nano evolvable hardware (N-EHW) mechanisms for biological and electronics applications. CNRs combine to organize into complex geometrical structures and reaggregate their structural configurations in real time as they adapt to the feedback of evolving environmental conditions to solve complex optimization problems.

Abstract: The invention describes immunocomputing methods for application to collectives of nanorobots (CNRs). The system provides a hybrid synthesis of adaptive immune system problem solving and anticipatory problem solving in the CNR environment. Modeling methods are advanced to guide the transformation process of CNRs in the context of evolvable hardware, including a time-series modeling approach.

Abstract: The invention discloses the use of collectives of nanorobots (CNRs) for medical applications. CNRs are used (a) to map the human body, (b) to regulate the cardio-vascular system, (c) for insulin regulation, (d) for targeted drug delivery, (e) for diagnosis of cellular pathologies and (f) for destroying tumor cells.

Abstract: A system for nanorobotics and microrobotics is disclosed with apparatuses for (a) assembly of joints, (b) connection of top-down nano structures, (c) micro-pump, (d) nano-balloon and (e) nanosail. The nano-balloon and nanosail apparatuses provide for nanorobotic mobility.

Abstract: The invention pertains to the use of nanotechnology in photovoltaic (PV) cells. The apparatus is comprised of a multilayer crystalline media within which are embedded adaptive nanofilaments. The system efficiently emulates the natural process of photosynthesis and includes an efficient storage capability. A method of fabrication of the components and the apparatus is also disclosed.

Abstract: The invention describes a system for collective nanorobotics (CNRs) for electronics applications. CNRs are used to selectively activate electronics devices and remote devices and to target objects in sensor networks. A method of delivering CNRs in aerosol form is specified. The CNRs use reaggregation methods to restructure their shapes on-demand for improved material resistance capabilities.

Abstract: A nanorobotic apparatus is described consisting of hybrid MEMS and NEMS components. The nanorobot contains sensors for situational awareness. The apparatus has nanofilament components for communications.

Abstract: The invention describes apparatuses for nano-scale integrated circuits applied to nanorobotics. Using EDA techniques, the system develops fully functional nano ICs, including ASICs and microprocessors. Three dimensional nano ICs are disclosed for increased efficiency in nanorobotic apparatuses. Nano-scale FPGAs are disclosed. The nano-scale semiconductors have applications to nano-scale and micro-scale robots.

Abstract: A system, methods and apparatus are described involving the self-organizing dynamics of networks of distributed computers. The system is comprised of complex networks of databases. The system presents a novel database architecture called the distributed transformational spatio-temporal object relational (T-STOR) database management system (dbms). Data is continuously input, analyzed, organized, reorganized and used for specific commercial and industrial applications. The system uses intelligent mobile software agents in a multi-agent system in order to learn, anticipate, and adapt and to perform numerous functions, including search, analysis, collaboration, negotiation, decision making and structural transformation. The system links together numerous complex systems involving distributed networks to present a novel model for dynamic adaptive computing systems, which includes plasticity of collective behavior and self-organizing behavior in intelligent system structures.