Abstract: A film-based dosage form is provided. The dosage form includes a film base comprising a film-forming agent, a plasticizer and a solvent; and a matrix incorporated within the film base which comprises a target molecule that exhibits low aqueous solubility which is encapsulated and solubilized in a micellar formulation comprising a detergent in an aqueous solvent. The dosage form is particularly useful for administration of cannabinoids.
Abstract: A formulation for solubilizing a water insoluble pharmaceutical agent is provided. The formulation comprises: a water-insoluble pharmaceutical agent, a detergent, an enzyme that breaks down lipids, proteins, and/or starches, a plasticizing agent, an emulsifying agent and an aqueous solvent. A method of making the formulation is also provided.