Abstract: A thermally insulated sandwich polyurethane (PUR) shipper for a temperature sensitive payload is provided. The sandwich PUR shipper comprises an outer corrugated box, an inner corrugated box, vacuum insulated panels (such as VIP panels) and PUR foam. The inner box is nested within the outer box and has a bottom, sides and a top. The inner box defines a payload compartment. The VIP panels are adhered to the outer facing surfaces of the inner box. Preferably the VIP panels are wedged against each other so that a side edge of one VIP panel abuts an adjacent VIP panel. The PUR foam fills the space between the VIP panels and the outer box. The PUR foam may cover the top edges of the VIP panels.