Abstract: The present invention relates to a CPT-bound compound or a pharmaceutically acceptable salt thereof, the CPT-bound compound being obtained by binding CPT (or a CPT derivative) and guanidine to a reduced monosaccharide. The CPT-bound compound enhances solubility and cell permeability of the CPT drug, which makes it possible to effectively deliver CPT to target cells. Therefore, a pharmaceutical composition comprising, as an active ingredient, the CPT-bound compound or a pharmaceutically acceptable salt thereof is expected to be able to effectively treat cancer, in particular, colorectal cancer, even with a low dose of CPT.

Abstract: The present invention relates to a method for producing an interleukin-2 protein using methylotrophic yeast. The method for producing interleukin-2 according to the present invention shows high cell growth and protein synthesis rates by use of the established optimal cell line, and produces a large amount of a protein comprising interleukin-2 by use of the established optimal culture conditions utilizing methanol that is an inexpensive carbon source. In addition, the method according to the present invention isolates and purifies the protein by a simple process. Accordingly, the method according to the present invention highly pure interleukin-2, and thus has a significant effect on the mass-production of interleukin-2.

Abstract: The present disclosure relates to a method for preparing a novel sugar alcohol with a modified, that is, increased or decreased surface area and/or porosity while having flowability as a solid phase, and also to a sugar alcohol prepared by the preparing method or a pharmaceutical composition, a cosmetic composition, a food composition and a feed composition, comprising the sugar alcohol as a carrier. According to the present disclosure, the method for preparing a sugar alcohol comprises: (A) reacting the sugar alcohol in a solid state with a solvent (S), wherein the solid state sugar alcohol is not dissolved by the solvent (S) and is reacted with the solvent (S) as a solid dispersion; and (B) removing the solvent (S) therefrom. The sugar alcohol prepared by the preparing method of the present disclosure has a modified, that is, increased or decreased surface area and/or porosity in comparison with a conventional sugar alcohol.

Abstract: The present invention relates to an ibuprofen conjugate in which ibuprofen (S-(+)-ibuprofen) is covalently linked to a guanidine-terminal-group-bound sugar alcohol derivative and to a pharmaceutical composition containing the same. The ibuprofen conjugate in which ibuprofen is covalently linked to a guanidine-terminal-group-bound sugar alcohol derivative can more effectively penetrate into the brain by passing through the blood-brain barrier (BBB), thus enabling efficient drug delivery to the brain, whereby administration of the ibuprofen conjugate in an optimal dose can minimize side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and can prevent or treat degenerative brain disease.

Abstract: The present invention relates to an ibuprofen conjugate in which ibuprofen (S-(+)-ibuprofen) is covalently linked to a guanidine-terminal-group-bound sugar alcohol derivative and to a pharmaceutical composition containing the same. The ibuprofen conjugate in which ibuprofen is covalently linked to a guanidine-terminal-group-bound sugar alcohol derivative can more effectively penetrate into the brain by passing through the blood-brain barrier (BBB), thus enabling efficient drug delivery to the brain, whereby administration of the ibuprofen conjugate in an optimal dose can minimize side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and can prevent or treat degenerative brain disease.

Abstract: The present invention relates to an interleukin-2 expression construct for yeast, comprising a methanol oxidase (MOX) promoter; a human serum albumin gene or a fragment thereof; and an interleukin-2 (IL-2) gene, and to a yeast comprising the expression construct. The interleukin-2 expression construct for yeast according to the present invention makes it possible to produce an expressed and secreted fusion protein of human serum albumin (HSA) and interleukin-2 at low costs and easily separate recombinant interleukin-2 from the fusion protein. Thus, the interleukin-2 expression construct for yeast may be effectively used to produce a large amount of recombinant interleukin-2 with high purity.

Abstract: As described herein, an peptide of SEQ ID NO: 1 is modified at the terminal end. Specifically, the carboxyl-group of the leucine at the terminal end of the amino acid sequence FCIGRL (SEQ ID NO: 1) is modified with a —CONH2. This modified peptide is used as a permeation enhancer to boost the mucous membrane permeation, thereby noticeably increasing the bioavailability of a drug that is administered together with the modified peptide. The drug to be administered with the modified peptide can be cyclosporine A.

Abstract: Gamma-ray sensing probes operating under the Cerenkov effect measure the burnup of spent nuclear fuel assemblies. The probes include an optical fiber that reacts to gamma rays coming from the spent nuclear fuel assembly and emit light via the Cerenkov effect. A scatterer surrounds the optical fiber to increase the light emitting efficiency of the optical fiber by the Compton electron scattering. A collimator composed of shielding material surrounds the scatterer. The collimator has a slit groove which is open in one direction for directing the gamma rays from the spent fuel assembly to the scatterer.

Abstract: A planar type magic tee includes a first coupling unit, a second coupling unit, and transmission lines for connecting the first coupling unit and the second coupling unit to each other in a cascading manner, the transmission lines having different characteristic impedances. The planar type magic tee is capable of solving the problem caused due to the intrinsic limitation in bandwidth of a conventional ring hybrid coupler.

Abstract: The present invention provides a preparation method for agomelatine-resorcinol and agomelatine-hydroquinone co-crystals using the solvent-antisolvent method that enables a commercial mass production. The co-crystals prepared by the preparation method of the present invention displays high dissolution rate and high stability in acidic-to-neutral media.

Abstract: A novel C1-phosphate log of uridine-5?-diphosphate (UDP)-GlcNAc as an effective OGT (O-linked N-acetylglucosamine (O-GlcNAc) transferase) inhibitor, and a preparation method for the same provides a compound having an OGT inhibitory effect that can be used as a useful tool in the studies on various vital phenomena in association with the protein modification by O-GlcNAc within cells and furthermore as a candidate substance in the treatment or research of diseases related to the protein modification by O-GlcNAc, such as cancers, diabetes, or degenerative neurological diseases.

Abstract: An exercise equipment for rehabilitation of hand grip and wrist is disclosed herein. The exercise equipment includes a fixing module being fixed to a forearm of a user, a wrist exercising module having a hinge shaft on one side of the fixing module and being connected to the fixing module so as to be capable of performing rotating movements when rotating the arm, and a hand grip exercising module being provided on the wrist exercising module and measuring a hand grip of the user.

Abstract: Provided are a gamma-ray sensing probe using the Cerenkov effect, and a system for identifying the burnup of a spent nuclear fuel assembly using the gamma-ray sensing probes, wherein the system is established using the gamma-ray sensing probe including: an optical fiber reacting to gamma rays coming from the spent nuclear fuel assembly by the Cerenkov effect and emitting light by itself; a scatterer surrounding the optical fiber to increase light emitting efficiency of the optical fiber by the Cerenkov effect; and a collimator configured to surround the scatterer and composed of a shielding material, the collimator having a slit groove which is open in one direction, whereby the burnup of the spent nuclear fuel assembly can be accurately determined.

Abstract: Provided is a muscle retractor for spine surgery including: first and second retractors having blades configured to support a spine and muscles, and insertion blocks extending from the blades and having facing open surfaces; an expander having expansion arms slidably inserted into the insertion blocks of the first and second retractors, a gear rack movably installed at both of the expansion arms and having a gear section formed at one surface thereof, and a ratchet installed at the expansion arm moving along the gear rack and locked to or released from the gear section of the gear rack; a slider accessibly inserted into the blade of the first retractor or the second retractor in a projected state; and an auxiliary plate pivotally installed at a lower portion of the blade of the first retractor of the first and second retractors supporting the muscles.

Abstract: A method for fabricating an artificial bone by multi-pass extrusion, includes: a first extrusion process of forming roll-shaped filaments having sheets of calcium phosphate/calcium phosphate-(t-ZrO2)/t-ZrO2; a second extrusion process of arranging the prepared roll-shaped filaments circularly and extruding the same; and a third extrusion process of forming an external shell of hydroxyapatite (HAp). The method for fabricating an artificial bone allows fabrication of an artificial bone having the biocompatibility and mechanical strength of the natural bone and may be utilized variously in biomedical engineering, medicine and other applications.

Abstract: Disclosed are a microstrip transmission line having a common defected ground structure (DGS) and a wireless circuit apparatus having the same. The microstrip transmission line realizes a common defected ground structure (DGS) and a double microstrip structure, and includes: a first dielectric layer; a first signal line pattern formed on a first surface of the first dielectric layer; a common ground conductive layer formed on a second surface of the first dielectric layer and having a defected ground structure, the first surface facing the second surface; a second dielectric layer having a first surface brought into contact with the common ground conductive layer, and facing the first dielectric layer while interposing the common ground conductive layer between the first dielectric layer and the second dielectric layer; and a second signal line pattern formed on a second surface of the second dielectric layer, the first surface facing the second surface.

Abstract: Provided are a system and method for decentralizing public transportation passengers using a transportation card reader. The system includes a vehicle terminal including a transportation card reader counting the number of touches of transportation cards of riding and exiting passengers of a public transportation means and configured to transmit a count value to a center, an integrated database server provided in the center and configured to update a count value of each public transportation means with a transmitted count value of the public transportation means and transmit the updated count value to a station, a station terminal provided at the station and configured to display the updated and transmitted count value, and a mobile device configured to receive information on the riding and exiting passengers of the public transportation means from the integrated database server or the station terminal and output the received information.

Abstract: A method of reforming a metal surface of a cooling or circulating system of a nuclear or thermal power plant is provided. The method of reforming a metal surface of a cooling or circulating system of a nuclear or thermal power plant includes injecting metal ions or metal nanoparticles into a cooling or circulating system of a nuclear or thermal power plant (S11), converting the injected metal ions into metal particles by a chemical reaction with hydrogen (H2), hydrazine (N2H4), or amine in water (S12), and forming an insulating layer or a catalyst layer by depositing metal particles or metal nanoparticles on a metal surface or an oxide coating film of the cooling or circulating system (S13).

Abstract: Provided are an apparatus for supplying amine, including: transfer pipe through which amine is transferred; a heat wire which heats the amine that flows through the transfer pipe; a temperature control sensor which controls the temperature in the transfer pipe; and a product recovery valve which recovers product resulting from thermal decomposition of the amine, and a method for supplying amine using the same. The apparatus and method for supplying amine are capable of economically and effectively supplying amine utilizing the thermal decomposition properties of the amine, and may be used to supply amine, for example, to circulating water for power plants.

Abstract: Provided is an apparatus for recovering amines from amine-containing waste water generated in power stations, etc., and regenerating a cation exchange resin. The apparatus includes: a cation exchange resin layer capturing amines from amine-containing waste water and eluting the amines therefrom; a degassing tower degassing the eluted amines; a vacuum pump connected to the degassing tower; and a condensation and cooling tower condensing the degassed amines at a temperature of ?33° C. or lower, wherein the amines captured in the cation exchange resin layer are eluted by injecting a strong acidic solution, while the resin is regenerated, and the amines eluted by the strong acidic solution is subjected to vacuum degassing and then recovered. Provided also is a method for recovering amines and regenerating a cation exchange resin using the apparatus. The apparatus and method for recovering amines and regenerating a cation exchange resin improve the quality of effluent water from power stations, etc.