Abstract: The invention disclosed comprises methods, apparatuses and compositions to treat acute and chronic wounds with pressures altered from atmospheric. The methods, apparatuses and compositions herein improve the performance of Altered Pressure wound therapy. The improvements also make the treatments more comfortable for the patient and the delivery of the treatment more convenient for clinicians. These improvements collectively result in improved efficacy, improved compliance, improved safety and improved clinical efficiency, while limiting clinical errors in treatment.

Abstract: Compositions and methods for sealing, coating and adhering tissues are provided that utilize a polymeric system comprising at least a Polymer and a crosslinking agent; and, optionally, (i) a Gelation Disrupting Agent, (ii) an Augmentative Polymer or Monomer, (iii) an Adjunct Compound (iv) an Antimicrobial Agent (v) an Adhesion Enhancer, (vi) a Crosslink Augmentating Agent or any combination thereof. Additionally, a Therapeutic Agent may be incorporated.

Abstract: Therapeutic formulations adapted for positive-pressure application for controlling biological fluid at a desired site in a subject, absorbent articles comprising therapeutic formulations, and anti-infective devices coated with therapeutic formulations, said formulations comprising about 25% to about 99% by weight liquid-crystal forming compound and 0% to about 75% by weight solvent. In addition, methods of using said formulations including methods for controlling biological fluid at a desired site in a subject, methods for controlling blood loss, and methods for facilitating effective closure of a vascular wound or incision site at a desired site in a subject are disclosed, the methods comprising administering particular formulations comprising liquid-crystal forming compounds and solvents that are described herein.

Abstract: The invention disclosed comprises methods, apparatuses and compositions to treat acute and chronic wounds with pressures altered from atmospheric. The methods, apparatuses and compositions herein improve the performance of altered pressure wound therapy. The improvements also make the treatments more comfortable for the patient and the delivery of the treatment more convenient for clinicians. These improvements collectively result in improved compliance, improved efficacy, improved safety and improved efficiency, while limiting clinical errors in treatment.

Abstract: The invention disclosed comprises methods, apparatuses and compositions to treat acute and chronic wounds with pressures altered from atmospheric. The methods, apparatuses and compositions herein improve the performance of altered pressure wound therapy. The improvements also make the treatments more comfortable for the patient and the delivery of the treatment more convenient for clinicians. These improvements collectively result in improved compliance, improved efficacy, improved safety and improved efficiency, while limiting clinical errors in treatment.