Patents Assigned to Southwest Foundation for Biomedical Research
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Patent number: 6852710Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: GrantFiled: April 11, 2003Date of Patent: February 8, 2005Assignee: Southwest Foundation for Biomedical ResearchInventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Publication number: 20030229061Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: ApplicationFiled: April 11, 2003Publication date: December 11, 2003Applicant: SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCHInventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Patent number: 6593321Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.Type: GrantFiled: June 11, 2002Date of Patent: July 15, 2003Assignee: Southwest Foundation for Biomedical ResearchInventors: Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley
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Patent number: 5910424Abstract: A cell line of metastatic, pigmented, malignant melanoma cells made by exposing a litter of Monodelphis domestica suckling young to an accumulated dose of ultraviolet radiation and then continuing the ultraviolet exposure after the young are weaned to induce malignant melanoma tumors and culturing the tumor cells from lymph nodes. This cell line can be used to test anti-cancer agents in vitro. Further this cell line can be injected into Monodelphis domestica suckling young so that tumors develop in the animals, and the anti-cancer agents can be tested in vivo.Type: GrantFiled: December 3, 1997Date of Patent: June 8, 1999Assignee: Southwest Foundation for Biomedical ResearchInventors: Thomas P. Dooley, Edward S. Robinson
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Patent number: 5869332Abstract: A cell line of metastatic, pigmented, malignant melanoma cells made by exposing a litter of Monodelphis domestica suckling young to an accumulated dose of ultraviolet radiation and then continuing the ultraviolet exposure after the young are weaned to induce malignant melanoma tumors and culturing the tumor cells from lymph nodes. This cell line can be used to test anti-cancer agents in vitro. Further this cell line can be injected into Monodelphis domestica suckling young so that tumors develop in the animals, and the anti-cancer agents can be tested in vivo.Type: GrantFiled: June 3, 1994Date of Patent: February 9, 1999Assignee: Southwest Foundation for Biomedical ResearchInventors: Thomas P. Dooley, Edward S. Robinson
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Patent number: 5767265Abstract: With the DNA sequence (SEQ ID NO:4:) of monkey B virus which codes for the gB glycoprotein (UL27) (SEQ ID NO:6:) and a portion (UL28) (SEQ ID NO:5:) of an ICP 18.5 kilodalton polypeptide (UL28), methods for early detection of the presence of monkey B virus in humans and monkeys can be performed by amplifying primer sequences and distinguishing the monkey B virus DNA coding for UL27 or UL28 from other herpes virus gB DNA using unique reaction conditions to permit unequivocal differentiation.Type: GrantFiled: October 10, 1995Date of Patent: June 16, 1998Assignee: Southwest Foundation for Biomedical ResearchInventors: Richard Eberle, Darla Black, Franco Scinicariello, Julia Hilliard
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Patent number: 5519001Abstract: A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically-acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4 kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW: 31 kD) or modified apo E (MW: 41 kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically effective amount of the polypeptide disclosed herein.Type: GrantFiled: February 24, 1995Date of Patent: May 21, 1996Assignee: Southwest Foundation for Biomedical ResearchInventors: Rampratap Kushwaha, Henry C. McGill, Jr., Patrick Kanda
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Patent number: 5512548Abstract: A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically-acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW:31kD) or modified apo E (MW:41kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically affective amount of the polypeptide disclosed herein.Type: GrantFiled: February 8, 1994Date of Patent: April 30, 1996Assignee: Southwest Foundation for Biomedical ResearchInventors: Rampratap Kushwaha, Kathleen Born, Henry C. McGill, Jr., Patrick Kanda, Raymond G. Dunham
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Patent number: 5487969Abstract: With the DNA sequence (SEQ ID NO:4:) of monkey B virus which codes for the gB glycoprotein (UL27) (SEQ ID NO:6:) and a portion (UL28) (SEQ ID NO:5:) of an ICP 18.5 kilodalton polypeptide (UL28), methods for early detection of the presence of monkey B virus in humans and monkeys can be performed by amplifying primer sequences and distinguishing the monkey B virus DNA coding for UL27 or UL28 from other herpes virus gB DNA using unique reaction conditions to permit unequivocal differentiation.Type: GrantFiled: April 1, 1993Date of Patent: January 30, 1996Assignee: Southwest Foundation for Biomedical ResearchInventors: Richard Eberle, Darla Black, Franco Scinicariello, Julia Hilliard
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Patent number: 5028675Abstract: A polyamide resin for use in peptide and protein synthesis, and a method of preparing and using same. The polyamide resin is prepared by cross-linking a dimethylacrylamide monomer by co-polymerization with a functional monomer in an aqueous solution, emulsifying the aqueous solution in an organic solvent and isolating the polyamide resin beads formed by adding an initiator and a promoter. The beads are used as a solid phase for peptide and protein synthesis according to methods known in the art. The conjugate of the polyamide resin and the synthesized peptide or protein is used directly for immunoassays or immunization without the need for separation of the peptide or protein from the resin and subsequent purification.Type: GrantFiled: February 10, 1989Date of Patent: July 2, 1991Assignees: Southwest Foundation for Biomedical Research, Baylor College of MedicineInventors: Patrick Kanda, Ronald C. Kennedy, James T. Sparrow
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Patent number: 4956273Abstract: Composition and method for detection of and vaccination against the viral causative agents of AIDS and ARC. The composition is a synthetic peptide, the amino acid sequence of which is sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV-III, LAV or ARC to produce an immunogenic response in a patient and which has a hydrophilic region therein. The composition may be conjugated to an appropriate carrier for use as a vaccine against AIDS and ARC or bound to the ligand of a specific binding pair, contacted with a sample of biological fluid from a patient suspected of having contracted AIDS or ARC and thereafter contacted with the anti-ligand of the specific binding pair for detection of any antibodies against the viral causative agents of AIDS or ARC which may be present in the sample.Type: GrantFiled: March 28, 1989Date of Patent: September 11, 1990Assignees: Southwest Foundation For Biomedical Research, President and Fellows of Harvard CollegeInventors: Ronald C. Kennedy, Gordon R. Dreesman, Myron Essex