Patents Assigned to SRU Biosystems, LLC
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Publication number: 20100231907Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: ApplicationFiled: May 18, 2010Publication date: September 16, 2010Applicant: SRU BIOSYSTEMS, LLCInventors: Homer Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
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Publication number: 20080052006Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: ApplicationFiled: May 15, 2007Publication date: February 28, 2008Applicant: SRU BIOSYSTEMS, LLCInventors: Homer Pien, William Karl, Derek Puff, Peter Li, Brian Cunningham
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Publication number: 20050214803Abstract: A method for providing amine functional groups on a surface for binding proteins, peptides, DNAs, cells, small molecules, and other chemical or biological molecules that are of interests in the areas of proteomic, genomic, pharmaceutical, drug discovery, and diagnostic studies.Type: ApplicationFiled: November 8, 2004Publication date: September 29, 2005Applicant: SRU BIOSYSTEMS, LLCInventor: Guo Wang
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Publication number: 20040132214Abstract: The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.Type: ApplicationFiled: September 22, 2003Publication date: July 8, 2004Applicant: SRU Biosystems, LLCInventors: Bo Lin, Brian Cunningham, Peter Li
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Publication number: 20030113766Abstract: Amine functionalized colorimetric resonant biosensor for binding proteins, peptides, DNAs, cells, small molecules, and other chemical or biological molecules that are of interests in the areas of proteomic, genomic, pharmaceutical, drug discovery, and diagnostic studies. The invention relates to a coating process that provides a high density of active amine binding sites on the grating surface of the colorimetric resonant biosensor. The method uses chemical reagents that do not alter or degrade a plastic biosensor structure. The invention further provides for test methods that verify the presence of amine moieties on the activated surface on the colorimetric resonant biosensor.Type: ApplicationFiled: August 26, 2002Publication date: June 19, 2003Applicant: SRU BIOSYSTEMS, LLCInventors: Jane W. Pepper, Jean Qiu
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Publication number: 20030092075Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. Specifically, the invention herein provides a robust and reproducible method for coating sensor surfaces with aldehyde functional groups as well as methods for testing the efficiency and completeness of the coating process.Type: ApplicationFiled: September 3, 2002Publication date: May 15, 2003Applicant: SRU Biosystems, LLCInventor: Jane Pepper
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Publication number: 20030077660Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.Type: ApplicationFiled: September 25, 2002Publication date: April 24, 2003Applicant: SRU BIOSYSTEMS, LLCInventors: Homer Pien, William C. Karl, Derek Puff, Peter Li, Brian Cunningham
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Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
Publication number: 20030068657Abstract: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.Type: ApplicationFiled: September 9, 2002Publication date: April 10, 2003Applicant: SRU Biosystems LLCInventors: Bo Lin, Jane Pepper, Brian T. Cunningham, John Gerstenmaier, Peter Li, Jean Qiu, Homer Pien -
Publication number: 20030059855Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of detection locations comprises a light source for generating collimated white light. A beam splitter directs the collimated white light towards a surface of a sensor corresponding to the detector locations. A detection system includes an imaging spectrometer receiving the reflected light and generating an image of the reflected light.Type: ApplicationFiled: June 26, 2002Publication date: March 27, 2003Applicant: SRU Biosystems, LLCInventors: Brian T. Cunningham, Peter Y. Li
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Publication number: 20030032039Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.Type: ApplicationFiled: June 26, 2002Publication date: February 13, 2003Applicant: SRU Biosystems, LLCInventors: Brian T. Cunningham, Peter Y. Li, Frank DeFilippi
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Publication number: 20030027328Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.Type: ApplicationFiled: January 28, 2002Publication date: February 6, 2003Applicant: SRU Biosystems, LLCInventors: Brian T. Cunningham, Jane Pepper, Bo Lin, Peter Li, Jean Qiu, Homer Pien
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Publication number: 20030026891Abstract: Methods of producing liquid handling biosensor devices are provided. The liquid handling biosensor devices allow detection of biomolecular interactions in liquid. The use of labels is not required and the methods can be performed in a high-throughput manner.Type: ApplicationFiled: July 23, 2002Publication date: February 6, 2003Applicant: SRU Biosystems, LLCInventors: Jean Qiu, Peter Li, Brian Cunningham
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Publication number: 20030027327Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.Type: ApplicationFiled: January 28, 2002Publication date: February 6, 2003Applicant: SRU Biosystems, LLCInventors: Brian T. Cunningham, Jane Pepper, Bo Lin, Peter Li, Homer Pien, Jean Qiu
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Publication number: 20030017581Abstract: A machine and process for a pattern, such as a submicron grating pattern onto a substrate.Type: ApplicationFiled: July 23, 2002Publication date: January 23, 2003Applicant: SRU Biosystems, LLCInventors: Peter Li, Jean Qiu, Alex Borsody
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Publication number: 20030017580Abstract: The invention provides a methods for fabricating colorimetric resonant reflection biosensors.Type: ApplicationFiled: July 15, 2002Publication date: January 23, 2003Applicant: SRU Biosystems, LLCInventors: Brian T. Cunningham, Jean Qiu
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Publication number: 20020127565Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.Type: ApplicationFiled: August 15, 2001Publication date: September 12, 2002Applicant: SRU Biosystems, LLCInventors: Brian Cunningham, Jane Pepper, Bo Lin, Peter Li, Homer Pien