Patents Assigned to SSP Co., Ltd.
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Patent number: 6252067Abstract: A method of preparing oxoquazepam which comprises reacting 2,2,2-trifluoroethyl trifluoromethanesulfonate with 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one in tetrahydrofuran or ethyl acetate in the presence of potassium carbonate under reflux. According to the method of the present invention, high purity oxoquazepam can be manufactured in high yields.Type: GrantFiled: October 1, 1999Date of Patent: June 26, 2001Assignee: SSP Co., Ltd.Inventors: Masaki Ogawa, Fumio Kita
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Patent number: 6229049Abstract: The invention relates to a process for preparing a difluoroacetophenone derivative (4) by alkylthionating a compound (1) into a compound (2) and reacting this compound with a compound (3). wherein X1 is Cl, Br or I, X2 and X3 are independently a halogen atom, H or perfluoroalkyl group, X4 is a halogen atom, R1 is an alkyl, aryl or aralkyl group, and R2 is methyl, ethyl or cyclopropyl group.Type: GrantFiled: January 21, 2000Date of Patent: May 8, 2001Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Susumu Sato
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Patent number: 6218402Abstract: Disclosed herein are quinoline derivatives having dual mechanistic properties, referred to in this patent document as “acetylcholine enhancers”, i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, and 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-[2-(1-benzylpiperizin-4-yl) ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [3,4-b] quinolin-1-one hemifumarate, referred to herein as Compound A (“Cm.A”).Type: GrantFiled: June 9, 1999Date of Patent: April 17, 2001Assignees: Arena Pharmaceuticals, Inc., SSP Co., LtdInventors: Derek T. Chalmers, Susumo Sato, Tadayuki Koda
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Patent number: 6207184Abstract: A hydrophilic adhesive mass contains 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate. This hydrophilic adhesive mass is excellent in adhesiveness, and especially when combined with a pharmacologically active ingredient, is suitable for use in providing hydrophilic plasters.Type: GrantFiled: June 11, 1999Date of Patent: March 27, 2001Assignee: SSP Co., Ltd.Inventors: Yasuo Ikeda, Hirohisa Okuyama, Kenji Ishigaki, Shuichi Kasai, Katsumi Imamori
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Patent number: 6204415Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: April 18, 2000Date of Patent: March 20, 2001Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 6197326Abstract: This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and biocompatibility, and (b) a drug. When applied directly to a joint area, this preparation can achieve a high drug concentration at the target area, can inhibit occurrence of general side effect, and can maintain drug efficacy over a long term. The preparation can therefore alleviate the burden on the patient.Type: GrantFiled: October 14, 1998Date of Patent: March 6, 2001Assignee: SSP Co., Ltd.Inventors: Makoto Suzuki, Kenji Ishigaki, Minoru Okada, Kenji Ono, Shuichi Kasai, Katsumi Imamori
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Patent number: 6194592Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: April 18, 2000Date of Patent: February 27, 2001Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 6184396Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: April 18, 2000Date of Patent: February 6, 2001Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 6172266Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: December 23, 1999Date of Patent: January 9, 2001Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 6124347Abstract: Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R.sup.1 s represent alkyl, alkoxy or like groups, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.Type: GrantFiled: September 29, 1998Date of Patent: September 26, 2000Assignee: SSP Co., Ltd.Inventors: Fumio Ishii, Haruyoshi Honda, Fujiko Konno, Tomomi Okada, Terumitsu Kaihoh, Yoshihiro Nagao, Susumu Sato, Hideaki Matsuda
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Patent number: 6083968Abstract: Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient.The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: December 9, 1998Date of Patent: July 4, 2000Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 6071943Abstract: Disclosed herein are an imidazole derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, or an alkyl, alkoxy or alkoxycarbonyl group, and R.sup.2, R.sup.3 and R.sup.4 are the same or different from one another and are independently a hydrogen or halogen atom, an alkyl, halogenoalkyl, hydroxyl or alkoxy group, or the like, or a salt thereof, and a medicine comprising such a compound. The compound specifically suppresses the production of particular cytokine and is hence useful as an active ingredient for immune function modulators and the like.Type: GrantFiled: November 30, 1998Date of Patent: June 6, 2000Assignee: SSP Co. Ltd.Inventors: Noriaki Shioiri, Tadashi Mikami, Shinichi Morimoto, Kazuo Yamazaki, Hiroyuki Naito, Junji Okawa, Noriyuki Kawamoto, Hiroshi Hasegawa, Koichi Tachibana, Susumu Sato, Toshio Yokoyama
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Patent number: 6060485Abstract: Described is an arylacetic amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents an aryl group or the like, R.sup.2 and R.sup.3 each independently represents an alkyl group, a cycloalkyl group or the like, and R.sup.4 represents an aralkyl group, an alkyl group or the like; or salt thereof. The compound according to the present invention has both excellent anticholinergic action and calcium antagonism and at the same time has high selectivity to bladder, so that it is useful as a preventive or remedy for urinary disorders.Type: GrantFiled: October 28, 1998Date of Patent: May 9, 2000Assignee: SSP Co., Ltd.Inventors: Terumitsu Kaihoh, Tomomi Okada, Yoshinori Takahashi, Hiroyuki Mizuno, Haruyoshi Honda, Susumu Sato
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Patent number: 6040325Abstract: Described is a triazole derivative represented by the formula (1): wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient.The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: January 22, 1999Date of Patent: March 21, 2000Assignee: SSP Co., Ltd.Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 6028081Abstract: Substituted quinolone derivatives represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted (hetero)aryl group, R.sup.2 represents H or an alkoxycarbonyl, substituted aminocarbonyl, cyano or like group, and R.sup.3 and R.sup.4 each independently represent H or a substituted alkyl, aryl, amino or like group, and salts thereof; pharmaceuticals containing the same. These derivatives and salts have excellent anti-ulcer activities.Type: GrantFiled: August 27, 1998Date of Patent: February 22, 2000Assignee: SSP Co., Ltd.Inventors: Yoshihisa Sada, Shigeru Adegawa, Kinichi Mogi, Haruyoshi Honda, Hiromichi Eto, Shinichi Morimoto, Junji Okawa, Norimitsu Umehara, Susumu Sato
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Patent number: 6008239Abstract: Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.Type: GrantFiled: August 17, 1998Date of Patent: December 28, 1999Assignee: SSP Co., Ltd.Inventors: Yasushi Kaneko, Sunao Takeda, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
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Patent number: 5962509Abstract: Disclosed are dithiolylidene acetamide derivatives represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represent a hydrogen atom or an alkyl group, or salts thereof; and pharmaceuticals containing them as effective ingredients. The dithiolylidene acetamide derivatives and their salts show AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.Type: GrantFiled: October 13, 1998Date of Patent: October 5, 1999Assignee: SSP Co., Ltd.Inventors: Fumio Ishii, Kinichi Mogi, Hiromichi Eto, Susumu Sato, Hideaki Matsuda