Abstract: Biomarkers and methods for identifying circulating serum-based cfDNA sequences. The cfDNA sequences (PDcRAs) can be used to differentiate patient's suffering from Parkinson's disease (PD) from non-PD patients.

Abstract: Biomarkers and methods for identifying, verifying and confirming circulating serum-based microRNAs. The microRNAs (PrognomiRs) can be used to differentiate patient's suffering from rapid progressing Parkinson's disease (PD) from slow progressing PD patients.

Abstract: Biomarkers and methods for identifying, verifying and confirming circulating serum-based microRNAs. The microRNAs (PARKmiRs) can be used to differentiate patient's suffering from Alzheimer's disease (AD) from non-AD patients.

Abstract: Biomarkers and methods for identifying, verifying and confirming circulating serum-based microRNAs. The microRNAs (PARKmiRs) can be used to differentiate patient's suffering from Parkinson's disease (PD) from non-PD patients.

Abstract: A method for providing a resolution to an open issue is described. The method includes utilizing structured corresponding learning to determine pivots from a database having historical data records to determine data records having similar open issues and providing their resolution. The method further includes providing a recommended resolution for the open issue based on the historical data records.

Abstract: A method for providing a resolution to an open issue is described. The method includes utilizing structured corresponding learning to determine pivots from a database having historical data records to determine data records having similar open issues and providing their resolution. The method further includes providing a recommended resolution for the open issue based on the historical data records.

Abstract: Solid dosage forms containing nanoparticles are prepared where sugar esters serve as nanoparticle stabilizers that prevent agglomeration of nanoparticles during preparation of the solid dosage form and allow for restoration of the original nanoparticle size of the nanoparticles upon redispersion of the solid dosage form in aqueous media.

Abstract: Methods for the treatment of solid tumor cancers, specifically ovarian cancer and drug-resistant solid tumors, are disclosed. A method comprises administering a combination therapy including a therapeutically effective amount of an HDAC inhibitor and a therapeutically effective amount of an IKK inhibitor to a subject in need thereof. Pharmaceutical compositions and kits comprising an HDAC inhibitor and an IKK inhibitor are also disclosed.

Abstract: A film adhesion detection device comprises: a testing member, which comprises: a carrier, which is on the testing member and is capable of vacuum suction to adsorb a testing sample, the carrier can raise, move, rotate, and position; a testing cutting tool, which is on the testing member and is capable of dismantling from the testing member; a counterpoise, which is on the testing cutting tool to provide a suitable weight to the testing cutting tool according to the strength and thickness of the testing sample; and a tape adhesion testing device, which is on the testing member and has a tape-outputting wheel, a counterpoise and a tape recovery wheel, the tape adhesion testing device provides a suitable adhesion force to the testing sample via the counterpoise, the tape recovery wheel tears off a tape after the tape is on a film.

Abstract: A film adhesion detection device comprises: a testing member, which comprises: a carrier, which is on the testing member and is capable of vacuum suction to adsorb a testing sample, the carrier can raise, move, rotate, and position; a testing cutting tool, which is on the testing member and is capable of dismantling from the testing member; a counterpoise, which is on the testing cutting tool to provide a suitable weight to the testing cutting tool according to the strength and thickness of the testing sample; and a tape adhesion testing device, which is on the testing member and has a tape-outputting wheel, a counterpoise and a tape recovery wheel, the tape adhesion testing device provides a suitable adhesion force to the testing sample via the counterpoise, the tape recovery wheel tears off a tape after the tape is on a film.

Abstract: The present invention relates to methods of treating multidrug resistance in cancerous cells with phosphodiesterase (PDE) inhibitors, e.g., PDE5 inhibitors. More specifically, the invention relates to methods of treating multidrug resistance that arises, e.g., during administration of chemotherapeutic/antineoplastic (anticancer) agents for treatment of cancer, with a PDE5 inhibitor (e.g., sildenafil, vardenafil, and tadalafil). The invention also relates to methods of treating cancer, e.g., multidrug resistant cancer, using a PDE5 inhibitor in combination with an antineoplastic therapeutic agent. Further, the invention relates to pharmaceutical compositions for treating multidrug resistant cancers comprising a PDE5 inhibitor, or a combination of a PDE5 inhibitor and an antineoplastic agent.

Abstract: The present invention relates to methods of treating multidrug resistance in cancerous cells with phosphodiesterase (PDE) inhibitors, e.g., PDE5 inhibitors. More specifically, the invention relates to methods of treating multidrug resistance that arises, e.g., during administration of chemotherapeutic/antineoplastic (anticancer) agents for treatment of cancer, with a PDE5 inhibitor (e.g., sildenafil, vardenafil, and tadalafil). The invention also relates to methods of treating cancer, e.g., multidrug resistant cancer, using a PDE5 inhibitor in combination with an antineoplastic therapeutic agent. Further, the invention relates to pharmaceutical compositions for treating multidrug resistant cancers comprising a PDE5 inhibitor, or a combination of a PDE5 inhibitor and an antineoplastic agent.

Abstract: A method for dimming operation of a lamp includes the steps of generating a trapezoidal wave signal in response to an input square wave low frequency dimming gating signal, and generating a driving signal that has a low frequency when the trapezoidal wave signal has a low level, that has a high frequency when the trapezoidal wave signal has a high level, that shifts gradually from the low frequency to the high frequency when the trapezoidal wave signal goes from the low level to the high level, and that shifts gradually from the high frequency to the low frequency when the trapezoidal wave signal goes from the high level to the low level. A module that performs the method is also disclosed.

Abstract: Lipophilic fluorescein-based molecules have been synthesized and incorporated into thin plasticized polymeric membrane films as chromoionophores for the optical sensing and detection of polycationic protamine. The membrane response is based on the extraction of protamine into the film due to the interaction between the anionic fluorescein and the protamine polycation which results in a cation exchange between the protamine and proton, and thus, induces an absorbance spectra change of the polymeric film. The response speed is controlled by protamine diffusion through the stagnant diffusion layer adjacent to the film surface as well as within the bulk of the polymer film. When limited exposure time and non-stirring detection modes are used in a buffer solution, absorbance of a film changes as a function of the protamine concentration in the range of about 2 to 60 .mu.g/ml (0.44 to 13.3 .mu.M).

Abstract: Non-compressed sustained release tablets which will float on gastric fluid are described. The tablets comprise a hydrocolloid gelling agent, a therapeutically acceptable inert oil, the selected therapeutic agent and water.

Abstract: Antifungal and antibacterial compounds, compositions containing the same, and method of using the same comprising triorganotin 5-nitro-2-furoates represented by Formula (I) ##STR1## wherein R, which may be the same or different, is an alkyl group, a cycloalkyl group, an aryl group or an aralkyl group, as the active ingredient.

Abstract: A flask for establishing and maintaining environmental control for microbial cultures. The flask has a body resembling an erlenmeyer flask, and a screw capped large opening in the top thereof. The flask also has three sidearm tubes extending through its walls, one for outlet of gas from the flask, and another, extending into the flask to a point near its bottom, which functions as a gas input conduit. A third sidearm tube is provided for inoculation of the flask and sampling of its contents. Each sidearm is provided with a septum-type plug and a perforated screw cap to hold the plug in sealing position. The plugs and caps permit aseptic injection and withdrawal of gas or liquid to and from the flask by means of hypodermic needles inserted through the caps and plugs without disturbing the atmospheric conditions established within the flask. Methods for use of the apparatus for establishing and maintaining aerobic and anaerobic environmental systems are also disclosed.