Abstract: An larvicide comprising an essential oil encapsulated within a non-viable yeast cell. The larvicide is particularly effective against mosquito larvae, non-toxic to humans and other non-target species, inexpensive to make, and non-toxic during manufacture, transport, and storage.
Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry-breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.
Type:
Grant
Filed:
December 23, 2016
Date of Patent:
April 10, 2018
Assignee:
STC.UNM
Inventors:
Sang Eon Han, Brittany R. Hoard, Sang M. Han, Swapnadip Ghosh
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
Type:
Grant
Filed:
November 26, 2014
Date of Patent:
March 27, 2018
Assignee:
STC.UNM
Inventors:
Steven R. J. Brueck, Jeremy Scott Edwards, Alexander Neumann, Yuliya Kuznetsova, Edgar A. Mendoza, C. Jeffrey Brinker
Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.
Type:
Grant
Filed:
December 5, 2014
Date of Patent:
March 27, 2018
Assignee:
STC.UNM
Inventors:
David L Vander Jagt, Lorraine M Deck, Robert E Royer, John E Heidrich
Abstract: The present invention is an apparatus and method of forecasting solar energy irradiance potential and subsequent photovoltaic output in a region. The apparatus and method includes collecting meteorological data for a given region and then estimating irradiance levels using parameters collected from the meteorological data. Solar energy production is then simulated using the collected meteorological data, estimated irradiance levels, and physical characteristics of a solar generating system in the given region at a predetermined time.
Type:
Grant
Filed:
March 30, 2015
Date of Patent:
March 20, 2018
Assignee:
STC.UNM
Inventors:
Anthony Robert Menicucci, Thomas P. Caudell, Andrea A. Mammoli
Abstract: The present invention provides a novel solution or route for metal phosphide (MPx) nanomaterials from the thermal decomposition of metal bis[bis(diisopropylphosphino)amide], M[N(PPri2)2]2, and/or single-source precursors. Synthetic routes to MPx nanomaterials may be used in energy applications including batteries, semiconductors, magnets, catalyst, lasers, inks, electrocatalysts and photodiodes.
Type:
Application
Filed:
April 8, 2016
Publication date:
March 15, 2018
Applicants:
STC.UNM, Sandia Corporation
Inventors:
Richard Alan Kemp, Diane Dickie, Bernadette A. Hernandez-Sanchez, Timothy N. Labert
Abstract: Methods for optimizing, designing, making, and assembling various component parts and layers to produce optimized MEAs. Optimization is generally achieved by producing multi-layered MEAs wherein characteristics such as catalyst composition and morphology, ionomer concentration, and hydrophobicity/hydophilicity are specifically tuned in each layer. The MEAs are optimized for use with a variety of catalysts including catalysts with specifically designed and controlled morphology, chemical speciation on the bulk, chemical speciation on the surface, and/or specific hydrophobic or hydrophilic or other characteristics. The catalyst can incorporate non-platinum group metal (non-PGM) and/or platinum group metal (PGM) materials.
Abstract: The invention is directed to a system and methods allowing a user to interact with one or more data applications—including for example, games, music, music composition and tactile stimulation—to simulate real-time multisensory output. The invention includes a music program, a music texture program and a simulation program.
Abstract: Synthetic materials that are useful as heterogeneous catalysts or electrocatalysts. The materials can be used to catalyze oxidation and/or reduction reactions and/or oxygen/hydrogen evolution/oxydation reactions.
Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.
Abstract: Systems and methods implementing a stack on a substrate, where the stack includes a plurality of films structured as layers to convert radiation incident to the stack to radiation of a nonlinear optical signal different from the incident radiation or to a harmonic of the incident radiation, can be used in a variety of applications. The stack can be structured having parameters selected with respect to conversion efficiency and bandwidth the converted radiation. Additional systems and methods can be used in a variety of applications.
Type:
Grant
Filed:
June 19, 2015
Date of Patent:
January 30, 2018
Assignee:
STC.UNM
Inventors:
Wolfgang G. Rudolph, Cristina Rodriguez
Abstract: The present disclosure relates to molecules that function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.
Type:
Application
Filed:
August 31, 2017
Publication date:
January 25, 2018
Applicants:
Ball State Innovation Corporation, STC.UNM
Inventors:
Susan A. McDowell, Robert E. Sammelson, Larry A. Sklar, Mark K. Haynes
Abstract: Provided is a sensor platform that includes a substrate, a plurality of nanochannels disposed on the substrate, and a plurality of electrodes, a waveguide disposed on the substrate and an analysis chamber and a reference chamber disposed on the substrate. Each electrode extends substantially across a width of the plurality of nanochannels. At least one analysis optical resonator is disposed in the analysis chamber and is optically coupled to at least a portion of the waveguide. The at least one analysis optical resonator is in fluid communication with at least one of the plurality of nanochannels. At least one reference optical resonator is disposed in the reference chamber and is optically coupled to at least a portion of the waveguide. The at least one reference optical resonator is in fluid communication with at least one other of the plurality of nanochannels.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
January 16, 2018
Assignees:
STC.UNM, WASHINGTON STATE UNIVERSITY
Inventors:
Sang M. Han, Cornelius F. Ivory, Mani Hossein-Zadeh
Abstract: Apparatus, systems, and methods of generating multi combs can be used in a variety of applications. In various embodiments, a passive resonator can be disposed in the laser cavity of a mode-locked laser to generate a nested frequency comb. The passive resonator can be a sample under investigation, where a characteristic of the sample is determined using the generated nested frequency comb. Additional apparatus, systems, and methods are disclosed.
Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.
Type:
Grant
Filed:
September 18, 2014
Date of Patent:
January 2, 2018
Assignees:
STC. UNM, National Technology & Engineering Solutions of Sandia, LLC
Abstract: A method and precursor for making carbon fibers and the like comprising carbon black modified with at least one cyclic compound promoter. A source of the carbon black may be recycled materials such as recycled tires or recycled plastics. The carbon black is modified by attaching at least one cyclic compound promoter to the outer periphery of the carbon black.
Abstract: An optimization technique for use with radiation therapy planning that combines stochastic optimization techniques such as Particle Swarm Optimization (PSO) with deterministic techniques to solve for optimal and reliable locations for delivery of radiation doses to a targeted tumor while minimizing the radiation dose experienced by the surrounding critical structures such as normal tissues and organs.
Type:
Grant
Filed:
April 30, 2015
Date of Patent:
December 19, 2017
Assignee:
STC.UNM
Inventors:
Shuang Luan, Daniel Andres Riofrio Almeida
Abstract: The present invention provides a relativistic magnetron including an anode with an entrant channel, the channel having an input end, an output end and a dimensional discontinuity between the ends. The channel is connected to the magnetron and has an anode defining an interaction space located between the dimensional discontinuity and output end. Also provided is a cathode, located upstream, a spaced distance away from the interaction space towards the input end, the cathode is adapted to send an electron beam into the interaction space where the electron beam forms a virtual cathode in the interaction space.
Abstract: The present invention provides a vehicle with redundant systems to increase the overall safety of the vehicle. In other aspects, the present invention provides a method for learning control of non-linear motion systems through combined learning of state value and action-value functions.
Type:
Grant
Filed:
August 25, 2015
Date of Patent:
November 28, 2017
Assignee:
STC.UNM
Inventors:
Arnold Peter Ruymgaart, Lydia Tapia, Aleksandra Faust, Rafael Fierro
Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.
Type:
Grant
Filed:
December 22, 2016
Date of Patent:
November 28, 2017
Assignees:
STC.UNM, The Regents of the University of California