Abstract: Rodenticidal compositions comprising an anticoagulant type rodenticide in combination with a fluorosurfactant of the amphoteric, anionic or cationic type, optionally admixed with a cereal grain bait, and a method of killing rodents by oral administration of such compositions.
Abstract: Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andHet is selected from 1,3,4-oxadiazol-2-yl and 5-alkylated derivatives thereof,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
Abstract: Compounds of the formulas ##STR1## wherein: Y is an alkylene bridge of 1-9 carbon atoms;R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms;R.sub.1 and R.sub.2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; andR.sub.8 is hydrogen or lower-alkyl of 1-5 carbon atoms,are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
Abstract: 2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of a 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.
Abstract: Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
Abstract: A connector for attachment of a plunger to a rubber piston in hypodermic syringe cartridge ampoules comprises a pin having a shank portion with a contiguous screw-threaded post portion and a ratchet head portion sized to rotatably fit within a cavity in said piston which thus prevents overtightening the plunger to the piston thereby obviating jamming of the piston in the bore of the cartridge.
Abstract: N-[(alkylamino)alkyl]-4,5-diaryl-1H-pyrazole-1-acetamides, wherein at least one of the aryl substituents is a pyridine, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.
Type:
Grant
Filed:
March 22, 1989
Date of Patent:
May 15, 1990
Assignee:
Sterling Drug Inc.
Inventors:
Denis M. Bailey, Thomas E. D'Ambra, Alan M. Ezrin
Abstract: Pyrazolo[3,4-b]quinolines having the formula ##STR1## where R is hydrogen, hydroxy or alkoxy; R.sub.2 is halogen, cyano, carbamyl, carboxy, lower-alkylcarbonyl, amino or aminomethyl; and R.sub.1 is hydrogen or selected substituents as defined herein, are useful as antiviral agents and/or as vasodilators.
Abstract: Aqueous solutions of aromatic percarboxylic acids, such as perbenzoic acids, stabilized with at least an equal amount in parts by weight as the amount of aromatic percarboxylic acid of the corresponding aromatic carboxylic acid and an aqueous solution of perglutaric acid stabilized with hydrogen peroxide and/or a 10% to 60% aqueous solution of hydrogen peroxide.
Abstract: N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.
Abstract: N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.
Type:
Grant
Filed:
March 22, 1989
Date of Patent:
February 6, 1990
Assignee:
Sterling Drug Inc.
Inventors:
Denis M. Bailey, George Y. Lesher, Thomas E. D'Ambra
Abstract: N-[(disubstituted amino)alkyl]-3,4 or 5-aryl-1H-pyrazole-1-acetamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.
Abstract: 3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalkanecarbonyl-1-tosyloxyalkyl- or haloalkyl-1H-indole with an amine.
Abstract: A dispenser including a container body, a mounting member fitted on the container body and a dispensing head such as an applicator head movably mounted on the mounting member. The mounting member includes an axially extending closure member with a pin member thereon. The dispensing head includes an aperture and an axially extending wall forming a skirted chamber beneath the aperture, the skirted chamber including slits at least one opening through the wall for controlling flow of material from outside the wall, through the opening and into the skirted chamber from the container body. The dispensing head is movable from an open position to a closed position wherein the closure member fits within the skirted chamber and the pin member fits within the aperture.
Abstract: 4-Arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, useful as analgesic agents, are prepared by reaction of a 3-arylcarbonyl-2-methylnitrobenzene with DMF dimethyl acetal; reductive cyclization of the product with hydrogen over a catalyst; and N-alkylation of the resulting 4-arylcarbonylindole with an appropriate 4-(halo-lower-alkyl)morpholine in the presence of a strong base.
Abstract: A powdered composition for freshening and deodorizing carpets comprising an inorganic sulfate, bicarbonate or chloride, an aluminum silicate clay, a liquid agglomerating agent, and a fragrance, and a method of use thereof comprising applying the composition uniformly to the carpet and thereafter removing it from the rug.
Abstract: N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an .omega.-aminoalkanol, followed by activation of the alcohol and displacement by an appropriate amine.