Patents Assigned to Stichting Katholieke Universiteit more particularly The University Medical Centre
  • PCA3, PCA3 Genes, and Methods of Use
    Publication number: 20170073776
    Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 16, 2017
    Applicants: Stichting Katholieke Universiteit, more particularly The University Medical Centre Nijmege, The Johns Hopkins University
    Inventors: Marion J.G. Bussemakers, William B. Isaacs
  • PCA3, PCA3 genes, and methods of use
    Patent number: 8551699
    Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: October 8, 2013
    Assignees: Stichting Katholieke Universiteit, more particularly The University of Medical Centre Nijmegen, The Johns Hopkins University
    Inventors: Marion J. G. Bussemakers, William B. Isaacs
  • PCA3, PCA3 genes, and methods of use
    Patent number: 7632643
    Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: December 15, 2009
    Assignees: Stichting Katholieke Universiteit, More Particularly the University Medical Centre Nijmegen, The Johns Hopkins University
    Inventors: Marion J. G. Bussemakers, William B. Isaacs
  • PCA3, PCA3 genes, and methods of use
    Patent number: 7008765
    Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: March 7, 2006
    Assignees: The Johns Hopkins University, Stichting Katholieke Universiteit more particularly The University Medical Centre
    Inventors: Marion J. G. Bussemakers, William B. Isaacs
  • Nucleic acid molecules comprising the promoter for PCA3, and uses thereof
    Patent number: 6897024
    Abstract: This invention describes the cloning and characterization of the promoter region for the PCA3dd3 gene. This region regulates the PCA3dd3 gene expression by a unique prostate specific transcriptional mechanism. The present invention relates to the use of this promoter region as a tool for prostate cancer treatment and diagnosis and screening of agents which regulate expression of PCA3. In a particular embodiment, the present invention relates to an isolated promoter sequence which comprises an isolated promoter sequence which comprises a sequence as set forth between nucleotide positions 372 to 460 of SEQ ID NO:1, this sequence enabling a prostate-specific modulation of transcription.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: May 24, 2005
    Assignee: Stichting Katholieke Universiteit more particularly The University Medical Centre Nijmegen
    Inventors: Marion J. Bussemakers, Gerald Verhaegh, Jack A. Schalken