Patents Assigned to Stichting Katholieke Universiteit
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Patent number: 10465230Abstract: The present invention relates to a method for in vitro determining generation of a haemostasis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.Type: GrantFiled: December 18, 2017Date of Patent: November 5, 2019Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventors: Waander Laurens Van Heerde, Richard Hendrik Blaauw
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Patent number: 10350298Abstract: The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example, for immunotherapy, such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.Type: GrantFiled: July 7, 2011Date of Patent: July 16, 2019Assignees: Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre, Stichting Katholieke Universiteit, meer in het bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Carl Gustav Figdor
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Publication number: 20190180419Abstract: A system for filtering an input image dataset is disclosed. A plurality of sequences of input signal values, wherein each sequence corresponds to a different attribute, wherein an input signal value is associated with an attribute and a sampling point i. At least one processor 4 is configured to control computing an output signal value corresponding to a sampling point and an attribute. For a particular sampling point i and for each of a plurality of different attributes of the set of attributes, associating a weight to an input signal value based on a similarity between the signal value and for a plurality of the sampling points j excluding the sampling point i. Also the system computes a weighted sum based on the input signal values and weights. The attribute is a location or a frequency.Type: ApplicationFiled: May 15, 2017Publication date: June 13, 2019Applicant: Stichting Katholieke UniversiteitInventors: Ewoud Joris Smit, Wolfgang Mathias Prokop
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Patent number: 10314508Abstract: Method for processing a brain wave signal (4) obtained from a person using a brain wave detector (5). One or more stimuli are applied to the person in which each of the one or more stimuli comprises a pseudo random noise component modulating the stimulus intensity. A brain wave signal (4) is detected after applying the one or more stimuli. The detected brain wave signal is processed to calculate which of the one or more stimuli is present in the detected brain wave signal using correlation techniques. The pseudo random noise component comprises a pseudo random noise sequence of the class of maximum length sequences, which are further modulated with twice their associated bit frequency.Type: GrantFiled: July 20, 2015Date of Patent: June 11, 2019Assignee: Stichting Katholieke UniversiteitInventors: Petrus Wilhelmus Maria Desain, Jordy Thielen, Philip Leonardus Cornelis van den Broek, Jason David Robert Farquhar
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Patent number: 10266809Abstract: A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol couplingType: GrantFiled: July 16, 2014Date of Patent: April 23, 2019Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventors: Alan Edward Rowan, Zaskia Hillet Eksteen Akeroyd, Christopher Wilson, Petrus Johannes Geutjes, Wouter F. J. Feitz, Egbert Oosterwijk
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Publication number: 20190038588Abstract: The present invention relates to the field of medicine, specifically the field of treatment and prevention of cardiovascular diseases.Type: ApplicationFiled: February 9, 2017Publication date: February 7, 2019Applicant: STICHTING KATHOLIEKE UNIVERSITEITInventors: Tom Johan Joseph Schirris, Tina Ritschel, Floris Petrus Johannes Theodorus Rutjes, Johannes Albertus Maria Smeitink, François Gérard Marie Russel
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Publication number: 20190017048Abstract: The invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Usher syndrome type 2A and/or USH2A-associated non syndromic retina degeneration.Type: ApplicationFiled: July 5, 2018Publication date: January 17, 2019Applicant: STICHTING KATHOLIEKE UNIVERSITEITInventor: Hendrikus Antonius Rudolfus VAN WYK
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Patent number: 10167470Abstract: The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Leber congenital amaurosis.Type: GrantFiled: April 26, 2018Date of Patent: January 1, 2019Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventors: Robert Wilhelmus Johanna Collin, Franciscus Peter Maria Cremers, Antonia Ingrid Den Hollander
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Publication number: 20180362935Abstract: The invention relates to the field of pharmacology, specifically the field of drug-drug interactions and nephrotoxicity. An engineered, stable cell line of human renal cells is provided that allows screening for drug-drug interactions and nephrotoxicity.Type: ApplicationFiled: December 7, 2016Publication date: December 20, 2018Applicant: Stichting Katholieke UniversiteitInventors: Martijn Wilmer, Rosalinde Masereeuw
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Patent number: 10131910Abstract: The invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Usher syndrome type 2A and/or USH2A-associated non syndromic retina degeneration.Type: GrantFiled: July 9, 2015Date of Patent: November 20, 2018Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventor: Hendrikus Antonius Rudolfus Van Wyk
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Patent number: 10125222Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: GrantFiled: December 8, 2016Date of Patent: November 13, 2018Assignee: STICHTING KATHOLIEKE UNIVERSITEIT MEER IN HET BIJZONDER RADBOUD UNIVERSITEIT NIJMEGENInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Patent number: 10098992Abstract: Heart support device for circulatory assistance, with an internal member (6) to be disposed inside a heart lumen (13) and having a dynamic volume body. The internal member (6) has a substantially stiff wall strengthening portion (8) arranged to engage an inner wall surface (12a) of the heart (10) in operation and a dynamic member (9) that is inflatable to assist pumping action of the heart (10).Type: GrantFiled: June 30, 2015Date of Patent: October 16, 2018Assignee: Stichting Katholieke UniversiteitInventors: Daniël Immanuel Michaël van Dort, Harry Suryapranata, Paul Frederik Gründeman, Jakob Roelf Lahpor
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Patent number: 10085779Abstract: An intramedullary device for treatment of a mid-shaft clavicle fracture includes a base pin (1) having a primary fixation element (2) and a connection part (3). A secondary fixation element (6) is provided which is attachable to the connection part (3) at a distance along the base pin with respect to the primary fixation element (2). The connection part (3) of the base pin (1) and the secondary fixation element (6) are rotatable with respect to each other when attached, e.g. using an end cap (7).Type: GrantFiled: December 3, 2014Date of Patent: October 2, 2018Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventor: Paul Hoogervorst
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Patent number: 10071987Abstract: A compound having the structure according to formula III wherein: X is NH or S; R1 is H or (1C-4C)alkyl; R2 is (1C-4C)alkyl, phenyl or a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, which alkyl, phenyl or aromatic ring is optionally substituted with one or more groups selected from (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, phenyloxy, phenylthio, halogen, or nitro; R3 and R4 are each independently H, (1C-6C)alkyl, (2C-6C) alkenyl, (2C-6C)alkynyl, cyano, (3C-6C)cycloalkyl, phenyl, a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, a monocyclic non-aromatic ring having one or more N—, O— or S— atoms in the ring, each optionally substituted with hydroxyl, (1C-4C)alkoxy, phenyl, cycloalkyl, piperidyl, piperazinyl, furyl, thienyl, pirazinyl, pyrrolyl, 2H-pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyrrolidonyl, pyrrolinyl, imidazolinyl, imidazolyl, a monocyclic aromatic ring having one or more N—, O— or S— atoms in the rType: GrantFiled: October 10, 2017Date of Patent: September 11, 2018Assignees: Compound Handling B.V., Stichting Katholieke UniversiteitInventors: Onno Van Hooij, Jacobus Antonius Schalken, Hendrik Engelbertus Vietor, Dennis Patrick Piet, Petrus Emmanuel Marie Maas, Johann Heinrich Tijhuis, Sirik Deerenberg, Nanda Elisabeth Sprenkels, Siu Ha Tang
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Publication number: 20180237749Abstract: The present invention relates to the field of medicine, specifically the field of treatment of cancer. More specifically, the invention relates to a method for the ex vivo production of a population of highly functional NK cells from CD34-positive cells, to a population of highly functional NK cells obtained and to the use of such population of highly functional NK cells for adoptive cell therapy.Type: ApplicationFiled: September 14, 2016Publication date: August 23, 2018Applicant: Stichting Katholieke UniversiteitInventor: Harmen Dolstra
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Publication number: 20180228829Abstract: The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Leber congenital amaurosis.Type: ApplicationFiled: September 3, 2015Publication date: August 16, 2018Applicant: Stichting Katholieke UniversiteitInventors: Robert Wilhelmus Johanna COLLIN, Franciscus Peter Maria CREMERS, Antonia Ingrid DEN HOLLANDER
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Publication number: 20180230545Abstract: The invention relates to the field of medicine, specifically the field of diagnosis and treatment of cancer.Type: ApplicationFiled: August 4, 2016Publication date: August 16, 2018Applicant: Stichting Katholieke UniversiteitInventors: Antoine G. van der Heijden, Lourdes Mengual Brichs
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Patent number: 9951390Abstract: Described herein are method, compositions and kits for prognosis of prostate cancer. The methods include determining the ratio of PCA3 and of a prostate-specific marker expression in a urine sample and correlating the value of the PCA3/prostate-specific marker ratio with the aggressiveness and mortality risk of prostate cancer in the subject. The method for prognosing prostate cancer in a sample of a patient includes assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of prostate-specific marker in the sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of prostate-specific marker; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value.Type: GrantFiled: April 13, 2016Date of Patent: April 24, 2018Assignee: Stichting Katholieke Universiteit, The University Medical Centre NijmegenInventors: Daphne Hessels, Gerald Verhaegh, Jack A. Schalken, J. Alfred Witjes
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Patent number: 9945918Abstract: A rapid cycle dynamic nuclear polarization (DNP) NMR apparatus comprises (i) a cooling unit configured to cool a sample in a capillary, (b) a DNP polarization unit configured to polarize the sample in the capillary, (c) a stripline-based NMR detector comprising a stripline for NMR analysis of the sample in the capillary, (d) a transport unit configured to guide the capillary from the DNP polarization unit to the stripline of stripline-based NMR detector; and (e) a heating unit configured to heat the sample in the capillary before analysis of the sample by the stripline-based NMR detector. Fast (1D-3D) NMR measurements with high resolution may be obtained.Type: GrantFiled: December 21, 2012Date of Patent: April 17, 2018Assignee: Stichting Katholieke UniversiteitInventors: Arnold Peter Maria Kentgens, Petrus Johannes Maria van Bentum
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Publication number: 20180030035Abstract: A compound having the structure according to formula III wherein: X is NH or S; R1 is H or (1C-4C)alkyl; R2 is (1C-4C)alkyl, phenyl or a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, which alkyl, phenyl or aromatic ring is optionally substituted with one or more groups selected from (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, phenyloxy, phenylthio, halogen, or nitro; R3 and R4 are each independently H, (1C-6C)alkyl, (2C-6C) alkenyl, (2C-6C)alkynyl, cyano, (3C-6C)cycloalkyl, phenyl, a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, a monocyclic non-aromatic ring having one or more N—, O— or S— atoms in the ring, each optionally substituted with hydroxyl, (1C-4C)alkoxy, phenyl, cycloalkyl, piperidyl, piperazinyl, furyl, thienyl, pirazinyl, pyrrolyl, 2H-pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyrrolidonyl, pyrrolinyl, imidazolinyl, imidazolyl, a monocyclic aromatic ring having one or more N—, O— or S— atoms in the rType: ApplicationFiled: October 10, 2017Publication date: February 1, 2018Applicants: Compound Handling B.V., Stichting Katholieke UniversiteitInventors: Onno Van Hooij, Jacobus Antonius Schalken, Hendrik Engelbertus Vietor, Dennis Patrick Piet, Petrus Emmanuel Marie Maas, Johann Heinrich Tijhuis, Sirik Deerenberg, Nanda Elisabeth Sprenkels, Siu Ha Tang